Anti-Inflammatory and Anti-Microbial Potential of Plumbago zeylanica L.: A Review

Aleem, Mohd

doi:10.22270/jddt.v10i5-s.4445

Cited by 12 publications

(9 citation statements)

References 27 publications

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“…P. zeylanica is a pharmacologically important plant. It exhibits broad range of pharmacological activities, which include antibacterial, antifungal, anti-inflammatory, antioxidant, and wound healing (Shweta and Dubey, 2015;Singh et al, 2017;Aleem, 2020). G. superba shows oxytocic activity and acts as an early abortifacient, maintains labour, aids the timely removal of placenta, and minimizes post-partum bleeding.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Acute Oral Toxicity of a Herbal Uterine

HAJARE¹,

INGOLE²,

INGAWALE³

et al. 2022

AJMBES

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Maintaining optimum reproductive health of animal is crucial for profitability in livestock enterprises and boosting the economy of farmers. However, the reproductive efficiency of animals is commonly reduced by problems such as puerperal metritis, clinical endometritis, pyometra, subclinical endometritis, early embryonic mortality, repeat breeding, retention of foetal membranes, and post-partum anestrus. ExaparTM Liquid (M/s Ayurvet Limited, India) is a polyherbal uterine cleanser and restorative that helps to achieve and restore better post-partum reproductive efficiency. This study aimed to evaluate the potential of Exapar TM Liquid to induce acute oral toxicity in mice as per OECD 423 guidelines. Nine healthy and adult nulliparous, non-pregnant Swiss albino female mice, weighing 24-28 g, were used for the study. The animals were observed for the manifestation of toxic effects and mortality after the oral administration of the test substance. Toxicity was evaluated on the basis of changes in body weight, signs of toxicity, gross and histological appearances of vital organs, and blood biochemistry. Exapar TM Liquid was found safe for oral use as no toxic effects or mortalities were observed up to the completion of experiment.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Acute Oral Toxicity of a Herbal Uterine

HAJARE¹,

INGOLE²,

INGAWALE³

et al. 2022

AJMBES

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“…Plumbagin lowered serum cholesterol and LDL-cholesterol, by 53-86% and 61-91% respectively. It lowered cholesterol / phospholipid ratio by 45.8% and elevated the decreased HDL-cholesterol significantly 77 . Marked reduction was seen with formulation of P. zeylanica and vitamin E. The total cholesterol/HDL and LDL/HDL cholesterol ratios were found significantly lowered.…”

Section: Hypolipidaemic Activitymentioning

confidence: 91%

Challenges and Perspectives on Plasmid Curing, Medicinal and Pharmacological Traits of Plumbago Zeylanica (Chitraka): A Review

Rajashree¹

2020

Int J Pharma Bio Sci

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“…Medicinal plants with anti-inflammatory properties were selected from the previous literatures (Aleem et al, 2020;Jeewanthi et al, 2020;Jamshed et al, 2019) and potential compounds identified from the selected plants were used as ligands in this study. The 3D structures of the selected ligands namely 6 urs-12-en-24-oic acid (Figure 2a) and β-Amyrin ( Figure 2b) from Plumbago zeylanica, 10,12-Docasadiyndioic Acid ( Figure 2c) and 1(Ethynyltrimethylsilyl-2)-1-Chloro-2-Ethyl-2-methyl cyclopropane (Figure 2d) from Neolitsea cassia, and Androstane (Figure 2e) from Wrightia tinctoria was collected from Pubchem (http://pubchem.ncbi.nlm.nih.…”

Section: Preparation Of Ligandsmentioning

confidence: 99%

In-silico molecular docking analysis of some plant derived molecules for anti-inflammatory inhibitory activity

Thamaraiselvi¹,

Selvankumar²,

Wesely³

et al. 2021

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Herbs are essential resources for drug discovery. However, numerous challenges stand in front of the scientific community to discover novel drugs from herbs. To explore the validation behind the precious knowledge of traditional medicine, we focused on achieving virtual screening to detect the potential medicines from the herbs. Five bioactive compounds from known anti-inflammatory medicinal plants were examined through molecular docking against cyclooxygenase-2 (COX-2) and inducible Nitric Oxide Synthase (iNOS), using AutoDock 4.2. The docking of selected ligands with COX-2 showed the binding energy varying from -6.15 Kcal/mol to ‑11.24 Kcal/mol. The docking energies of identified ligands with iNOS were generated ranges from -3.85kcal/mol to -6.99 kcal/mol. Among the tested ligands, it was noted that 6 urs-12-en-24-oic acid showed the best binding energy than other compounds with the lowest binding energy and highest binding affinity with both anti-inflammatory target proteins COX-2 and iNOS. The in silico study validates the potential phytochemical compound of the medicinal herb that contribute to anti-inflammatory activity with low toxicity and minimal side effects.

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Anti-Inflammatory and Anti-Microbial Potential of Plumbago zeylanica L.: A Review

Cited by 12 publications

References 27 publications

Evaluation of Acute Oral Toxicity of a Herbal Uterine

Evaluation of Acute Oral Toxicity of a Herbal Uterine

Challenges and Perspectives on Plasmid Curing, Medicinal and Pharmacological Traits of Plumbago Zeylanica (Chitraka): A Review

In-silico molecular docking analysis of some plant derived molecules for anti-inflammatory inhibitory activity

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