Anti-inflammatory and Anti-microbial Properties of Achillea millefolium in Acne Treatment

Shah, Rahul M.; Peethambaran, Bela

doi:10.1016/b978-0-12-805417-8.00019-6

Cited by 10 publications

(8 citation statements)

References 22 publications

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“…Achillea millefolium (yarrow) has anti-inflammatory, hemostatic, antimicrobial, antiseptic, and antioxidant properties [ 27 ]. The results are consistent with studies already conducted, showing beneficial effects on burning lesions [ 28 ].…”

Section: Discussionsupporting

confidence: 93%

Effects and Characterization of Some Topical Ointments Based on Vegetal Extracts on Incision, Excision, and Thermal Wound Models

et al. 2020

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The present paper aims to formulate and characterize four phytotherapeutic ointments based on Hippophae fructus, Calendulae flos, Bardanae folium, and Millefolii herba, which are included in a novel ointment base. In order to investigate the healing properties of the ointments, in vivo experimental wound models of linear incision, circular excision, and thermal burn were performed on Wistar rats. Topical treatment was performed daily for 21 days. Determination of the wound contraction rate (WCR), the period of reepithelization, and histopathological examination were achieved. Additionally, for the tested ointments, oscillatory and rotational rheological tests were carried out, and for the extracts, HPLC analysis was performed. The results demonstrate that the tested novel ointments are safe for use and the most effective ointment proved to be the one based on Arctium lappa, followed by that of Calendulae flos.

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Section: Discussionsupporting

confidence: 93%

Effects and Characterization of Some Topical Ointments Based on Vegetal Extracts on Incision, Excision, and Thermal Wound Models

et al. 2020

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“…Tissue repair scores for the epidermis and dermis of the rats that received C. acnes and were treated using farnesol, commercial antibiotic gel, or were untreated in the two-and four-time treatment groups. (4). Scores are expressed as means ± standard errors of means; significant differences were determined using one-way ANOVA and the Tukey-Kramer test.…”

Section: Histopathological Analysismentioning

confidence: 99%

“…Another common factor is the excessive growth of the bacterium Cutibacterium acnes , which is present on the skin [ 3 ]. C. acnes is a gram-positive, anaerobic, lipophilic bacterium and is often found in sebaceous follicles located on the face, chest, and back of the majority of humans [ 4 ]. C. acnes is involved in the development of inflammatory acne by activating complements and metabolizing sebaceous triglycerides into fatty acids that irritate the follicular wall and dermis nearby [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Efficacy of Sesquiterpene Farnesol in Treatment of Cutibacterium acnes-Induced Dermal Disorders

Wang

et al. 2021

Molecules

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Acne vulgaris is a highly prevalent skin disorder requiring treatment and management by dermatologists. Antibiotics such as clindamycin are commonly used to treat acne vulgaris. However, from both medical and public health perspectives, the development of alternative remedies has become essential due to the increase in antibiotic resistance. Topical therapy is useful as a single or combined treatment for mild and moderate acne and is often employed as maintenance therapy. Thus, the current study investigated the anti-inflammatory, antibacterial, and restorative effects of sesquiterpene farnesol on acne vulgaris induced by Cutibacterium acnes (C. acnes) in vitro and in a rat model. The minimum inhibitory concentration (MIC) of farnesol against C. acnes was 0.14 mM, and the IC50 of 24 h exposure to farnesol in HaCaT keratinocytes was approximately 1.4 mM. Moreover, 0.8 mM farnesol exhibited the strongest effects in terms of the alleviation of inflammatory responses and abscesses and necrotic tissue repair in C. acnes-induced acne lesions; 0.4 mM farnesol and clindamycin gel also exerted similar actions after a two-time treatment. By contrast, nearly doubling the tissue repair scores, 0.4 mM farnesol displayed great anti-inflammatory and the strongest reparative actions after a four-time treatment, followed by 0.8 mM farnesol and a commercial gel. Approximately 2–10-fold decreases in interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, found by Western blot analysis, were predominantly consistent with the histopathological findings and tissue repair scores. The basal hydroxypropyl methylcellulose (HPMC) gel did not exert anti-inflammatory or reparative effects on rat acne lesions. Our results suggest that the topical application of a gel containing farnesol is a promising alternative remedy for acne vulgaris.

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“…Acne vulgaris is a common skin disease affecting the vast majority of adolescents and a significant proportion of young adults. Approximately 85% of the population suffers from acne vulgaris at some point in their lives (Shah and Peethambaran, 2018). Acne negatively impacts self-esteem, self-confidence, and social life as it specifically affects the skin of the face, the chest, and the back—areas where the pilosebaceous gland concentration is the highest (Thomas, 2004; Titus and Hodge, 2012).…”

Section: Introductionmentioning

confidence: 99%

Growth Inhibitory Activity of Callicarpa americana Leaf Extracts Against Cutibacterium acnes

et al. 2019

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Acne vulgaris is a common skin disease affecting adolescents and young adults of all ethnic groups, negatively impacting self-esteem, self-confidence, and social life. The Gram-positive bacteria Cutibacterium acnes colonizes the sebum-rich follicle and contributes to inflammation of the pilosebaceous gland. Long-term antibiotic therapies targeting C. acnes lead to the development of antimicrobial resistance, and novel acne vulgaris therapies are needed. This study investigated the C. acnes inhibitory activity of Callicarpa americana leaves, a native Southeastern United States shrub historically used by Native Americans to treat fever, stomachache, and pruritis. Flash chromatography fractions of the ethyl acetate-soluble C. americana ethanol leaf extract (649C-F9 and 649C-F13) exhibited MICs ranging from 16 to 32 µg ml−1 and IC50 range of 4–32 μg ml−1 against a panel of 10 distinct C. acnes isolates. Cytotoxicity against an immortalized human keratinocyte cell line (HaCaTs) skin was detected at more than eight times the dose required for growth inhibitory activity (IC50 of 256 μg ml−1 for 649C-F9 and IC50 of >512 μg ml−1 for 649C-F13). This work highlights the potential of C. americana leaf extracts as a cosmeceutical ingredient for the management of acne vulgaris. Further research is necessary to assess its mechanism of action and in vivo efficacy.

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Anti-inflammatory and Anti-microbial Properties of Achillea millefolium in Acne Treatment

Cited by 10 publications

References 22 publications

Effects and Characterization of Some Topical Ointments Based on Vegetal Extracts on Incision, Excision, and Thermal Wound Models

Effects and Characterization of Some Topical Ointments Based on Vegetal Extracts on Incision, Excision, and Thermal Wound Models

Therapeutic Efficacy of Sesquiterpene Farnesol in Treatment of Cutibacterium acnes-Induced Dermal Disorders

Growth Inhibitory Activity of Callicarpa americana Leaf Extracts Against Cutibacterium acnes

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