Anti-Inflammatory and Anti-Nociceptive Effects of Cocoa: A Review on Future Perspectives in Treatment of Pain

Feo, Martina De; Paladini, Antonella; Ferri, Claudio; Carducci, Augusto; Pinto, Rita Del; Varrassi, Giustino; Grassi, Davide

doi:10.1007/s40122-020-00165-5

Cited by 19 publications

(23 citation statements)

References 51 publications

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“…Inhibition of the activation of trigeminal neurons and the expression of proteins involved in nociception in the ganglion and spinal cord [40][41][42].…”

Section: Health Benefits and Subjacent Metabolic Modulationsmentioning

confidence: 99%

“…Increase in peptides with anti-inflammatory and antinociceptive properties such as protein mitogen activated protein (MAP) kinase phosphatases 1 (MPK-1) [41,42].…”

Section: Health Benefits and Subjacent Metabolic Modulationsmentioning

confidence: 99%

“…Decrease in the expression of the peptide related to the calcitonin gene (CGRP) in the spinal trigeminal nucleus, same as at the glial cell level, it is capable of increasing cell activation, producing a greater amount of proinflammatory molecules [40][41][42].…”

Section: Health Benefits and Subjacent Metabolic Modulationsmentioning

confidence: 99%

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Potential applications of cocoa (Theobroma cacao) on diabetic neuropathy: mini-review

Kababie-Ameo¹,

Rabadán-Chávez²,

Vázquez-Manjarrez³

et al. 2022

Front. Biosci. (Landmark Ed)

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Diabetes Mellitus is a highly prevalent disease in Mexico and in the world, among whose complications is diabetic neuropathy. DN is a group of disorders that present signs and/or symptoms of peripheral nerve dysfunction and have different clinical manifestations in both peripheral neuropathy and autonomic neuropathy. As a part of the mechanisms by which DN develops, oxidative stress and inflammation have been described. Cocoa is a plant origin product which includes around 300 components and through different studies, it has been suggested that cocoa has different mechanisms of action through which exerts its beneficial effects on health. It has been proposed that cocoa has hypoglycemic, lipid-lowering, antioxidant and anti-inflammatory effects, and thus, potentially have a beneficial direct or indirect effect on diabetic neuropathy. Specially in preclinical studies, the anti-inflammatory and anti-nociceptive effect of cocoa has been evaluated through different mechanisms of action. However, most of the studies presented concerning this complication, are in vitro or preclinical studies, so there is still a great area of opportunity regarding the use of cocoa on diabetic neuropathy.

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“…Inhibition of the activation of trigeminal neurons and the expression of proteins involved in nociception in the ganglion and spinal cord [40][41][42].…”

Section: Health Benefits and Subjacent Metabolic Modulationsmentioning

confidence: 99%

“…Increase in peptides with anti-inflammatory and antinociceptive properties such as protein mitogen activated protein (MAP) kinase phosphatases 1 (MPK-1) [41,42].…”

Section: Health Benefits and Subjacent Metabolic Modulationsmentioning

confidence: 99%

See 1 more Smart Citation

Potential applications of cocoa (Theobroma cacao) on diabetic neuropathy: mini-review

Kababie-Ameo¹,

Rabadán-Chávez²,

Vázquez-Manjarrez³

et al. 2022

Front. Biosci. (Landmark Ed)

View full text Add to dashboard Cite

show abstract

“…Studies on cocoa, GSE, and purple corn extract provided satisfying results; thus, these foods are likely to be applied clinically. Cocoa, as a widely accepted food, contains various phytochemicals, including polyphenols, which suggest its possible effects in antiinflammation, antioxidation, and pain relief (De Feo et al, 2020). Rats fed by a cocoa-enriched diet for 2 weeks showed better resistance against trigeminal nerve activation induced by acute (capsaicin injection to eyebrow regions) and chronic (CFA injection to TMJ) stimuli.…”

Section: Terpenementioning

confidence: 99%

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Cai

et al. 2021

Front. Pharmacol.

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Temporomandibular joint disorders (TMD) are a common health condition caused by the structural or functional disorders of masticatory muscles and the temporomandibular joint (TMJ). Abnormal mandibular movement in TMD patients may cause pain, chronic inflammation, and other discomfort, which could be relieved by a variety of drugs through various delivery systems. In this study, we summarized commonly used therapeutic agents in the management of TMD as well as novel bioactive molecules in preclinical stage and clinical trials. The emerging therapy strategies such as novel intra-TMJ delivery systems and implants based on tissue engineering are also discussed. This comprehensive review will strengthen our understanding of pharmacological approaches for TMD therapy.

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“…Flavonoid constituents in various medicinal plants are known to possess a wide range of pharmacological activities, including anti-inflammatory effects. For example, the flavonol quercetin (3,3′,4′,5,7-pentahydroxyflavone), an anti-oxidant and a common naturally-occurring phytochemical, exerts a marked effect on inflammation [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Dual Anti-Malarial and GSK3β-Mediated Cytokine-Modulating Activities of Quercetin Are Requisite of Its Potential as a Plant-Derived Therapeutic in Malaria

et al. 2021

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Although death in malaria is attributed to cerebrovascular blockage and anaemia, overwhelming cytokine production can contribute to the severity of the disease. Therefore, mitigation of dysregulated inflammatory signalling may provide further benefit for malaria treatment. Quercetin (3,3′,4′,5,7-pentahydroxyflavone) is known to inhibit glycogen synthase kinase-3β (GSK3β), a potent regulator of both pro- and anti-inflammatory effects. Quercetin is therefore a potential therapeutic to modulate the imbalanced cytokine production during malarial infection. Anti-malarial effects of quercetin were evaluated in murine models of severe and cerebral malaria using Plasmodium berghei NK65 and ANKA strains, respectively. Western blotting and analysis of cytokines were carried out to determine the GSK3β-mediated cytokine-modulating effects of quercetin in infected animals. Quercetin (25 mg/kg BW) treatment in P. berghei NK65-infected animals resulted in 60.7 ± 2.4% suppression of parasitaemia and significantly decreased serum levels of TNF-α and IFN-γ, whilst levels of IL-10 and IL-4 were elevated significantly. Western analysis revealed that pGSK3β (Ser9) increased 2.7-fold in the liver of quercetin-treated NK65-infected animals. Treatment of P. berghei ANKA-infected mice with quercetin (15 mg/kg BW) increased (2.3-fold) pGSK3β (Ser9) in the brains of infected animals. Quercetin is a potential plant-derived therapeutic for malaria on the basis that it can elicit anti-malarial and GSK3β-mediated cytokine-modulating effects.

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Anti-Inflammatory and Anti-Nociceptive Effects of Cocoa: A Review on Future Perspectives in Treatment of Pain

Cited by 19 publications

References 51 publications

Potential applications of cocoa (Theobroma cacao) on diabetic neuropathy: mini-review

Potential applications of cocoa (Theobroma cacao) on diabetic neuropathy: mini-review

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Dual Anti-Malarial and GSK3β-Mediated Cytokine-Modulating Activities of Quercetin Are Requisite of Its Potential as a Plant-Derived Therapeutic in Malaria

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