Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis

Adzu, Bulus; Amos, Samson; Kapu, S. D.; Gamaniel, K.

doi:10.1016/s0378-8741(02)00295-7

Cited by 98 publications

(85 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acetic acid, a commonly used model for assessing the anti-nociceptive effects of drugs, causes an increase in peritoneal fluid of prostaglandin (PG) E2 and PGF2α involving in part, peritoneal pain receptor. 7 The comparable effects of the extract (200 and 400 mg/kg) and aspirin (100 mg/kg) ( Table 1) is a clear indication that the extract may have a similar mechanism of action with aspirin. Aspirin is a weak acid and NSAID, which is effective against mild or moderate pain, especially that arising from inflammation or damaged tissue.…”

Section: Discussionmentioning

confidence: 94%

“…The experiment was carried out by measuring tail withdrawal time from hot water as described by Adzu et al 7 30 mice were randomly divided into five groups (A-E) of six mice each and fasted for 12 hrs. The mice were treated as follows; Group A served as negative control and received 10 ml/kg distilled water per os, Group B served as positive control and received pentazocine (3 mg/kg) intraperitoneally while Group C-E received OTE (50, 100, and 200 mg/kg, respectively) per os.…”

Section: Effects Of Ote On Tail Flick Response In Micementioning

confidence: 99%

See 1 more Smart Citation

Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice

Ezeja¹,

Onoja²,

Omeh³

et al. 2015

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 94%

Section: Effects Of Ote On Tail Flick Response In Micementioning

confidence: 99%

Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice

Ezeja¹,

Onoja²,

Omeh³

et al. 2015

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

“…The response is thought to be mediated by peritoneal mast cells [19], acid sensing ion channels [20] and the prostaglandin pathways [21]. The organic acid has also been postulated to act indirectly by inducing the release of endogenous mediators, which stimulates the nociceptive neurons that are sensitive to NSAIDs and narcotics [22]. It is well known that non-steroidal anti-inflammatory and analgesic drugs mitigate the inflammatory pain by inhibiting the formation of pain mediators at the peripheral target sites where prostaglandins and bradykinin are proposed to play a significant role in the pain process [23].…”

Section: Resultsmentioning

confidence: 99%

Analgesic and Anti-Inflammatory Activities of some Transition Metal Schiff Base Complexes

Jesmin

Islam

Ali

2014

ILCPA

View full text Add to dashboard Cite

Analgesic and anti-inflammatory activities of four transition metal complexes of a Schiff base derived from salicylaldehyde and glycine, viz. 2 were studied in swiss albino mice. 10 mg/kg (p.o) dose for each compound were selected throughout the research work. The analgesic activity was determined by acetic acid induced writhing and tail immersion methods. All such data were compared with standard drugs at the dose of 10 mg/kg (p.o. The anti-inflammatory activity of the test compounds was determined by the carragenan induced mice paw edema inhibition method.). Analgesic and anti-inflammatory activities of the test compounds at 10 mg/kg (p.o.) were quite comparable to those of standard drugs at 10 mg/kg (p.o.). All these compounds can be considered as potent analgesic and anti-inflammatory agents.

show abstract

“…The tail immersion thermal pain test investigates pain primarily of spinal origin. 23 Pregabalin is a well-established anticonvulsant and analgesic agent that has shown efficacy and dose dependent effects either as monotherapy or in combination with analgesics in relieving pain and related symptoms. It is noteworthy that pregabalin has received Food and Drug Association (FDA) approval for the treatment of diabetic neuropathy and post-herpetic neuralgia.…”

Section: Discussionmentioning

confidence: 99%

Anti-Nociceptive Synergism of Pregabalin and Xylopic acid Co-administration in Paclitaxel induced Neuropathy: Isobolographic Analysis

Ofori¹,

Woode²,

Kyei³

et al. 2015

Phcog J

View full text Add to dashboard Cite

Background: Paclitaxel-induced neuropathy still remains a clinical problem for patients undergoing chemotherapy. Objective: The objective of the study was to determine the interaction between xylopic acid and pregabalinco-administration as well as their toxicity in paclitaxel-induced neuropathy. Materials and Methods: Neuropathic pain was induced in rats with 2 mg/ kg of paclitaxel on four alternate days (days 0, 2, 4 and 6). Equi effective doses of xylopic acid and pregabalin that produced 50% anti-nociception (ED 50 ) were determined from their log-dose response curves in the cold allodynia and thermal pain tests. Xylopic acid and pregabalin were again administered to rats in a fixed ratio combination (1:1) of their ED 50 's in order to determine the experimental ED 50 (Z exp ) of the co-administered compounds. Isobolograms were constructed to compare the Z exp to a theoretical ED 50 (Z add ). Blood samples from the various treatment groups of rats were collected for toxicological assessment of the co-administered compounds. Results: The Z exp lay below the Z add on the isobologram of the cold allodnia test. The co-administration exhibited additivity in the thermal pain test. The co-administration did not produce significant (p>0.05) toxicity in rats. The co-administration may be beneficial in paclitaxel-induced neuropathy.Key words: Isobolograms, Neuropathic pain, Paclitaxel, xylopic acid, Toxicity. SUMMARY• Paclitaxel-induced neuropathy is still a clinical problem.• Pregabalin and Xylopic acid co-administration produced anti-nociceptive synergism against this pain type.• The co-administration was fairly safe in animals. PICTORIAL ABSTRACTAbbreviations used: XA: Xylopic acid, PG: Pregabalin, Z add : Theoritical ED 50 , Z exp : Experimental ED 50 .

show abstract

Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis

Cited by 98 publications

References 13 publications

Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice

Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice

Analgesic and Anti-Inflammatory Activities of some Transition Metal Schiff Base Complexes

Anti-Nociceptive Synergism of Pregabalin and Xylopic acid Co-administration in Paclitaxel induced Neuropathy: Isobolographic Analysis

Contact Info

Product

Resources

About