Anti-inflammatory and anti-oxidant effects of Cardamom ( Elettaria repens (Sonn.) Baill) and its phytochemical analysis by 4D GCXGC TOF-MS

Kandikattu, Hemanth Kumar; Rachitha, P.; Jayashree, G.V.; Krupashree, K.; Sukhith, M.; Majid, Abdul Hafiz Ab; Amruta, Narayanappa; Khanum, Farhath

doi:10.1016/j.biopha.2017.04.049

Cited by 49 publications

(19 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As an inflammatory indicator, NO was synthesized by nitric oxide synthases (NOSs), and only i-NOS was activated in response to inflammatory stimuli [20]. PGE2, generated by the metabolism of arachidonic acid through the COX, was another major indicator in inflammation.…”

Section: Discussionmentioning

confidence: 99%

Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells

et al. 2019

View full text Add to dashboard Cite

Pterocephalus hookeri was used as a traditional Chinese medicine for the treatment of rheumatoid arthritis. Sweroside was a main iridoid isolated from P. hookeri. The present study aimed to investigate the anti-inflammatory effect mechanism of sweroside. In RAW264.7 cells induced by lipopolysaccharide (LPS), the abnormal proliferation, the NO content increase, and the downregulated Sirtuin1 (SIRT1) expression were observed. Sweroside could alleviate the inflammation by inhibiting cell proliferation through arresting the cell cycle at the G0/G1 phase, by suppressing pro-inflammatory cytokines and by promoting anti-inflammatory cytokines in LPS-induced RAW264.7 cells. Further mechanism research indicated that sweroside could activate the SIRT1, then suppress the nuclear factor-kappa B (NF-κB) and promote the Forkhead transcription factor O1 (FOXO1) signaling pathways. The present study indicated that sweroside may be the main anti-inflammatory constituent of P. hookeri and a promising candidate for anti-inflammation therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Phytochemicals are a series of compounds that are extracted and purified from plants such as vegetables, fruits, spices, and grains. Many studies have demonstrated the pharmacological activities of phytochemicals, including antioxidant [ 11 ], antimicrobial [ 12 ], antidiabetic [ 13 ], and anti-inflammatory effects [ 14 ]. Most recently, the anticancer and chemoprevention properties of phytochemicals have attracted increasing interest from oncology researchers due to their low intrinsic toxicity in normal cells but prominent effects in cancerous cells [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic inhibitory effects of capsaicin combined with cisplatin on human osteosarcoma in culture and in xenografts

Wang

Deng

Chang

et al. 2018

J Exp Clin Cancer Res

View full text Add to dashboard Cite

BackgroundThe combination of phytochemicals with chemotherapy drugs is an emerging new strategy for cancer therapy to increase antitumor responses.MethodsThe present study investigates the effect of the combination of capsaicin (CAP) with cisplatin (DDP) and the potential underlying anticancer mechanisms in osteosarcoma (OS) cells in vitro and in vivo.ResultsCell viability assays and isobolographic analyses demonstrated that the combination of CAP and DDP showed synergistic cytotoxic effects on OS cells. We chose relatively low concentrations of CAP (100 μM) and DDP (16.7 μM) for subsequent experiments. Generally, the combination of CAP and DDP had significant effects on apoptosis induction, cell cycle arrest and cell invasion inhibition in OS cells compared with the individual-treatment groups and the control group. Moreover, cotreatment with CAP and DDP triggered prosurvival autophagy through reactive oxygen species (ROS)/JNK and p-AKT/mTOR signaling in OS cells. The combination regimen of CAP and DDP also inhibited tumor growth in an OS xenograft model.ConclusionThese results suggest that the combination of CAP and DDP has strong inhibitory effects on OS cells and identify CAP as a promising agent for supplementing standard chemotherapy and possible future targeted therapy in OS.

show abstract

“…A study showed that the use of polyphenol extracted from Camellia sinensis (Black tea) results in increased Bacteroidetes compared to Firmicutes in a simulated intestinal microbiota [154]. Cardamom showed anti-inflammatory ability by acting as a cytokines inhibition agent [155,156]. Curcuma longa root (Turmeric) is excessively used as a major condiment in Asian food as well as a traditional therapy in Indian and Chinese traditional medicine.…”

Section: Nutraceuticals From Plant Originmentioning

confidence: 99%

Uncovering Prospective Role and Applications of Existing and New Nutraceuticals from Bacterial, Fungal, Algal and Cyanobacterial, and Plant Sources

et al. 2021

View full text Add to dashboard Cite

Nutraceuticals are a category of products more often associated with food but having pharmaceuticals property and characteristics. However, there is still no internationally accepted concept of these food-pharmaceutical properties, and their interpretation can differ from country to country. Nutraceuticals are used as part of dietary supplements in most countries. They can be phytochemicals which are biologically active and have health benefits. These can be supplied as a supplement and/or as a functional food to the customer. For human health and longevity, these materials are likely to play a vital role. Consumption of these items is typical without a therapeutic prescription and/or supervision by the vast majority of the public. The development of nutraceuticals can be achieved through many bioresources and organisms. This review article will discuss the current research on nutraceuticals from different biological sources and their potential use as an agent for improving human health and well-being, as well as the gaps and future perspective of research related to nutraceutical development.

show abstract

Anti-inflammatory and anti-oxidant effects of Cardamom ( Elettaria repens (Sonn.) Baill) and its phytochemical analysis by 4D GCXGC TOF-MS

Cited by 49 publications

References 57 publications

Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells

Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells

Synergistic inhibitory effects of capsaicin combined with cisplatin on human osteosarcoma in culture and in xenografts

Uncovering Prospective Role and Applications of Existing and New Nutraceuticals from Bacterial, Fungal, Algal and Cyanobacterial, and Plant Sources

Contact Info

Product

Resources

About