Anti-inflammatory and Anti-tumor Effects of Tetragonia tetragonoides Extracts

Choi, Hye Jung; Yee, Sung‐Tae; Kwon, Gi-Seok; Joo, Woo Hong

doi:10.4014/mbl.1509.09001

Cited by 7 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also can be consumed as a salad or herb in the West and is well known as a beneficial traditional herbal medicine for treating stomach diseases such as stomach ulcers and gastritis [ 29 , 31 , 32 ]. Previous studies of the antioxidant, antidiabetic, anti-inflammatory, and life prolongation effects of TTK crude extracts and fractions have been published [ 33 , 34 , 35 ]. Furthermore, the major constituents of TTK have been isolated and include soluble polysaccharides, sphingosine, diterpenoids, flavonol glycosides, and lignan amides such as cerebrosides, methyl linoleate, methyl coumarate, methyl ferulate, (2 S )-1- O -stearoyl-3- O -β- d -galactopyranosyl-sn-glycerol, 1- O -caffeoyl-β- d -glucopyranoside, N- trans caffeoyltyramine, cannabisin B, and cannabisin A [ 31 , 32 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Tetragonia tetragonioides (Pall.) Kuntze Regulates Androgen Production in a Letrozole-Induced Polycystic Ovary Syndrome Model

et al. 2018

View full text Add to dashboard Cite

Tetragonia tetragonioides (Pall.) Kuntze (TTK) is a medicinal plant traditionally used to treat various diseases such as diabetic, inflammatory, and female-related disorders. Polycystic ovary syndrome (PCOS) is a common endocrinological disorder in women of reproductive age, and hyperandrogenism is a prominent feature of PCOS resulting in anovulation and infertility. In this study, we investigated the effects of a TTK extract on androgen generation and regulation of steroidogenic enzymes in vitro and in vivo. Human adrenocortical NCI-H295R cells were used to assess the effects of TTK extract on production of dehydroepiandrosterone and testosterone, as well as the protein expression of steroidogenic enzymes. Further, a letrozole-induced PCOS rat model was used in vivo to assess whether dietary administration of TTK extract restores normal hormones and reduces PCOS symptoms. TTK extract significantly inhibited forskolin (FOR)-induced androgen production in NCI-H295R cells and serum luteinizing hormone, testosterone, and follicular cysts, but not estradiol, were reduced in letrozole-induced PCOS rats orally administered the TTK extract. In addition, TTK extract inhibits androgen biosynthesis through the ERK-CREB signaling pathway, which regulates CYP17A1 or HSD3B2 expression. TTK extract could be utilized for the prevention and treatment of hyperandrogenism and other types of PCOS.

show abstract

Section: Introductionmentioning

confidence: 99%

Tetragonia tetragonioides (Pall.) Kuntze Regulates Androgen Production in a Letrozole-Induced Polycystic Ovary Syndrome Model

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Positive results regarding the antitumour properties of T. tetragonioides were obtained in experiments on ICR mice inoculated with Sarcoma 180, which was a preliminary step towards the development of effective antitumour agents using T. tetragonioides [106].…”

Section: T Tetragonioides For Treating and Preventing Various Chronic...mentioning

confidence: 98%

BIOACTIVE COMPOUNDS AND PHARMACOGNOSTIC POTENTIAL OF Tetragonia tetragonioides

Onoiko

2024

Biotechnol. acta

View full text Add to dashboard Cite

In the recent years, due to the increasing resistance of pathogens to synthetic antimicrobial drugs, the use of highly active compounds from plants, which have proven their effectiveness in traditional medicine practices, is increased. Extracts of medicinal plants often contain a unique species ‒ specific combination of active ingredients that have a synergistic therapeutic effect. Therefore, the analysis of the biochemical composition of cultivated plants and the range of their potential biotechnological application is an urgent task. Aim. To summarize the information on the potential of the xerophytic plant Tetragonia tetragonioides as a source of functional food ingredients and biologically active substances that increase nonspecific organism resistance and contribute to the prevention and treatment of various diseases. Results. T. tetragonioides is a salt-tolerant and heat-resistant plant containing valuable nutrients and biologically active substances, a significant amount of vitamins, minerals, and dietary fibers. The high level of antioxidant compounds, especially flavonoids and carotenoids, helps to reduce the risk of degenerative pathologies developing associated with excessive oxidative stress. The unique complex of biologically active substances in T. tetragonioides, which includes 6-methoxyflavonols, predominantly derivatives of 6-methoxykaempferol, as well as megastigmanes and their glucosides, lignanamide, provides significant antioxidant, anti-inflammatory, antitumor, and antimicrobial activity and may be beneficial for the prevention of chronic diseases and age-related health problems. The effectiveness of T. tetragonioides has been demonstrated in animal models in the treatment of metabolic disorders such as obesity, hyperlipidemia, and hyperuricemia. Conclusions. T. tetragonioides, containing a specific complex of biologically active compounds, primarily 6-methoxyflavonols, may be a promising raw material for obtaining effective medications for the treatment and prevention of various chronic diseases and metabolic disorders.

show abstract

“…More than 211 chemical components of PS have been reported, including phenolic acids, terpenoids, resin glycosides, fatty acids, alkaloids, and volatile oils. These chemical components have significant pharmacological effects, such as increasing the propulsion rate of the large intestine, promoting gastrointestinal peristalsis, treating nephritis, and expelling parasites, as well as anticancer, phlegm-resolving, anti-inflammatory, and immunity-improving effects ( Choi et al, 2015 ; Xiang et al, 2017 ). Traditionally, PS is processed by plain stir-baking in accordance with “Lei’s Treatise on the Processing of Drugs,” a guideline book on the processing of TCM to yield active medicines ( Gao et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Dynamic changes in marker components during the stir-frying of Pharbitidis Semen, and network analysis of its potential effects on nephritis

Yuhe

Zhu

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Introduction: Pharbitidis Semen (PS) has been widely used in traditional Chinese medicine to treat several diseases such as nephritis. PS is usually stir-fried to enhance its therapeutic efficacy before use in clinical practice. However, the changes in phenolic acids during stir-frying and the mechanisms of their therapeutic effects on nephritis are still unclear.Methods: Here, we studied the processing-induced chemical changes and elucidated the mechanism of PS in the treatment of nephritis. We determined the levels of the 7 phenolic acids in raw PS (RPS) and stir-fried PS (SPS) using high-performance liquid chromatography, analyzed the dynamic compositional changes during stir-frying, and used network analysis and molecular docking to predict and verify compound targets and pathways corresponding to nephritis.Results: The dynamic changes in the 7 phenolic acids in PS during stir-frying are suggestive of a transesterification reaction. Pathway analysis revealed that the targets of nephritis were mainly enriched in the AGE-RAGE, hypoxia-inducible factor-1, interleukin-17, and tumor necrosis factor signaling pathways among others. Molecular docking results showed that the 7 phenolic acids had good binding ability with the key nephritic targets.Discussion: The potential pharmaceutical basis, targets, and mechanisms of PS in treating nephritis were explored. Our findings provide a scientific basis for the clinical use of PS in treating nephritis.

show abstract

Anti-inflammatory and Anti-tumor Effects of Tetragonia tetragonoides Extracts

Abstract: Anti-inflammatory and Anti-tumor Effects of Tetragonia tetragonoides Extracts

Cited by 7 publications

References 0 publications

Tetragonia tetragonioides (Pall.) Kuntze Regulates Androgen Production in a Letrozole-Induced Polycystic Ovary Syndrome Model

Tetragonia tetragonioides (Pall.) Kuntze Regulates Androgen Production in a Letrozole-Induced Polycystic Ovary Syndrome Model

BIOACTIVE COMPOUNDS AND PHARMACOGNOSTIC POTENTIAL OF Tetragonia tetragonioides

Dynamic changes in marker components during the stir-frying of Pharbitidis Semen, and network analysis of its potential effects on nephritis

Contact Info

Product

Resources

About