Anti-Inflammatory and Anti-Ulcerogenic Activities of Chantaleela Recipe

Sireeratawong, Seewaboon; Khonsung, Parirat; Piyabhan, Pritsana; Nanna, Urarat; Soonthornchareonnon, Noppamas; Jaijoy, Kanjana

doi:10.4314/ajtcam.v9i4.5

Cited by 8 publications

(12 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found although the active components in T. chebula may show significant differences in the proportions of active components but not much in terms of category when they collected from different growth condition. Based on previous reports and our current study, it is gratifying to find that extracts from T. chebula showed good antioxidant activity and anti-inflammatory activity with different dosage regardless of the growth condition (Seo et al, 2012;Sireeratawong et al, 2014;Yang et al, 2014;Liu et al, 2020).…”

Section: Discussionsupporting

confidence: 56%

Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula

Liu

Zhan²,

Zhang³

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

Background: The fruit of Terminalia chebula has been widely used for a thousand years for treating diarrhea, ulcers, and arthritic diseases in Asian countries. However, the active components of this Traditional Chinese medicine and their mechanisms remain unclear, necessitating further investigation.Objectives: To perform simultaneous quantitative analysis of five polyphenols in T. chebula and evaluate their anti-arthritic effects including antioxidant and anti-inflammatory activity in vitro.Materials and methods: Water, 50% water-ethanol, and pure ethanol were used as extract solvents. Quantitative analysis of gallic acid, corilagin, chebulanin, chebulagic acid, and ellagic acid in the three extracts was performed using high-performance liquid chromatography (HPLC). Antioxidant activity was assessed by the 2,2-diphenylpicrylhydrazyl (DPPH) radical-scavenging assay, and anti-inflammatory activity was evaluated by detecting interleukin (IL)-6 and IL-8 expression in IL-1β-stimulated MH7A cells.Results: The 50% water-ethanol solvent was the optimal solvent yielding the highest total polyphenol content, and the concentrations of chebulanin and chebulagic acid were much higher than those of gallic acid, corilagin, and ellagic acid in the extracts. The DPPH radical-scavenging assay showed that gallic acid and ellagic acid were the strongest antioxidative components, while the other three components showed comparable antioxidative activity. As for the anti-inflammatory effect, chebulanin and chebulagic acid significantly inhibited IL-6 and IL-8 expression at all three concentrations; corilagin and ellagic acid significantly inhibited IL-6 and IL-8 expression at high concentration; and gallic acid could not inhibit IL-8 expression and showed weak inhibition of IL-6 expression in IL-1β-stimulated MH7A cells. Principal component analysis indicated that chebulanin and chebulagic acid were the main components responsible for the anti-arthritic effects of T. chebula.Conclusion: Our findings highlight the potential anti-arthritic role of chebulanin and chebulagic acid from T. chebula.

show abstract

Section: Discussionsupporting

confidence: 56%

Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula

Liu

Zhan²,

Zhang³

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…An injection of yeast to the rats results in the increase of the body temperature (Janeway and Travers, 1999;Murphy and Ward, 2005;Sireeratawong et al, 2012). Ibuprofen can pass through the blood brain barrier (BBB) of the CNS to inhibit PGs synthesis in hypothalamic area which exhibits its antipyretic effect (Ganong, 2001).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-inflammatory, Analgesic, and Antipyretic Activities of Pseuderanthemum palatiferum

Inchab¹,

Khonsung²,

Chiranthanut³

et al. 2019

CMUJNS

View full text Add to dashboard Cite

The objectives of this study were to evaluate the anti-inflammatory, analgesic, and antipyretic activities of water extract from fresh leaves of Pseuderanthemum palatiferum (WEPP).The anti-inflammatory activity of WEPP was evaluated in ethylphenylpropiolate (EPP)-induced ear edema, carrageenan-induced paw edema, arachidonic acid (AA)-induced paw edema, and cotton pellet-induced granuloma experiments. Acetic acid-induced writhing and tail-flick experiments were conducted to evaluate analgesic activity. Finally, antipyretic activity was evaluated in yeast-induced hyperthermia model. WEPP showed the anti-inflammatory activity and the analgesic activity but without antipyretic property. WEPP (2 mg/ear) significantly inhibited edema thickness induced by EPP (75%). Oral administration of WEPP (600 mg/kg) significantly inhibited paw edema induced by carrageenan (57%), and arachidonic acid (47%). WEPP (600 mg/kg) did not significantly reduce the transudative weight, granuloma weight, and alkaline phosphatase activity in cotton pellet-induced granuloma formation model. The anti-inflammatory property of WEPP demonstrated on the acute phase and not on the chronic phase of inflammation. WEPP oral administration (150, 300, and 600 mg/kg) significantly reduced the writhing response induced by acetic acid by 21%, 57%, and 79%, respectively. In tail-flick test, WEPP slightly increased the reaction time of rats (25%). The analgesic activity of WEPP may act via peripheral pathway. The antipyretic effect of WEPP (600 mg/kg) was not observed in yeast-induced hyperthermia model. WEPP displays an anti-inflammatory effect and has a prominent analgesic effect on the peripheral system.

show abstract

“…In previous studies, the analgesic activity of ELJ was evaluated using the hot plate and acetic acid tests in mice, and its anti-inflammatory effect was demonstrated in carrageenan-induced paw edema in mice [15]. Notably, it is a component in the Chantaleela recipe, which in Thai traditional folk medicine is prescribed for fever relief and as an anti-inflammatory [14,16]. Apart from antipyretic effects and anti-inflammatory uses, it has been shown that "Radix" herbal remedies made from Althaea officinalis L., including ELJ, can successfully protect gastric mucosa against ethanol-induced gastric lesions [17].…”

Section: Introductionmentioning

confidence: 99%

“…Apart from antipyretic effects and anti-inflammatory uses, it has been shown that "Radix" herbal remedies made from Althaea officinalis L., including ELJ, can successfully protect gastric mucosa against ethanol-induced gastric lesions [17]. Although ELJ roots have been used in Thai traditional medicine, particularly in the Chantaleela formula, which has exhibited efficacy as an antipyretic treatment [16], there have been limited animal investigations on the anti-inflammatory, antipyretic, or gastroprotective effects of ELJ.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory, Antinociceptive, Antipyretic, and Gastroprotective Effects of Eurycoma longifolia Jack Ethanolic Extract

Subhawa

Arpornchayanon

Jaijoy

et al. 2023

Life

View full text Add to dashboard Cite

Tongkat ali (Eurycoma longifolia Jack) (ELJ) is a plant in the Simaroubaceae family. Its roots are used in traditional Thai medicine to treat inflammation, pain, and fever; however, the antiulcer abilities of its ethanolic extract have not been studied. This study examined the anti-inflammatory, antinociceptive, antipyretic, and gastroprotective effects of ethanolic ELJ extract in animal models and found that ELJ effectively reduced EPP-induced ear edema in a dose-dependent manner and that a high dose of ELJ inhibited carrageenan-induced hind paw edema formation. In cotton-pellet-induced granuloma formation, a high dose of ELJ suppressed the increases in wet granuloma weight but not dry or transudative weight. In the formalin-induced nociception study, ELJ had a significant dose-dependent inhibitory impact. Additionally, the study found that yeast-induced hyperthermia could be significantly reduced by antipyretic action at the highest dose of ELJ. In all the gastric ulcer models induced by chemical substances or physical activity, ELJ extracts at 150, 300, and 600 mg/kg also effectively prevented gastric ulcer formation. In the pyloric ligation model, however, the effects of ELJ extract on gastric volume, gastric pH, and total acidity were statistically insignificant. These findings support the current widespread use of Eurycoma longifolia Jack in traditional medicine, suggest the plant’s medicinal potential for development of phytomedicines with anti-inflammatory, antinociceptive, and antipyretic properties, and support its use in the treatment of gastric ulcers due to its gastroprotective properties.

show abstract

Anti-Inflammatory and Anti-Ulcerogenic Activities of Chantaleela Recipe

Cited by 8 publications

References 39 publications

Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula

Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula

Evaluation of Anti-inflammatory, Analgesic, and Antipyretic Activities of Pseuderanthemum palatiferum

Anti-Inflammatory, Antinociceptive, Antipyretic, and Gastroprotective Effects of Eurycoma longifolia Jack Ethanolic Extract

Contact Info

Product

Resources

About