Anti-inflammatory and Antibacterial Effects of Covalently Attached Biomembrane-Mimic Polymer Grafts on Gore-Tex Implants

Jin, Young Ju; Kang, Seok Jin; Park, Pona; Choi, Dong Hyun; Kim, Dae Woo; Jung, Dong Hyun; Koh, Jaemoon; Jeon, Jongwoo; Lee, Myoungjin; Ham, Jiyeon; Seo, Ji Hun; Jin, Hong; Lu, Yan

doi:10.1021/acsami.7b02696

Cited by 45 publications

(38 citation statements)

References 56 publications

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“…Moreover, it must be noted, that the cytoarchitectonics of the peri-implant mucosa differs significantly from the gingiva of the natural teeth. It is characterized by scar nature (low percentage of fibroblasts, irregulars collagen fibers structure), and a lack of periodontal space (diminished blood and interstitial blood flow), which decreases its permeability (Zhang et al., 2012 ; Jin et al., 2017 ).…”

Section: Antibacterial Biomaterials Active Surface Finishingmentioning

confidence: 99%

The paradigm shift for drug delivery systems for oral and maxillofacial implants

Pokrowiecki¹

2018

Drug Delivery

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Along with the development of nanotechnological strategies for biomaterials associated with the prevention of infections, a myriad of clinically unproven techniques have been described to date. In this work, the aim was to perform a critical analysis of the literature available concerning antibacterial biomaterials for oral implantology and to provide a practical derivation for such a purpose. As anti-adhesive strategies may affect osseointegration, they should no longer be recommended for inclusion in this class of biomaterials, despite promising results in biomedical engineering for other, non-bone load bearing organs. Targeted, antibacterial drug delivery is most likely desirable in the case of intraosseous implants. Interfering factors such as the oral cavity environment, saliva, the bacterial microbiome, as well as, the characteristics of the alveolar mucosa and peri-implant space must be taken into account when calculating the local pharmacokinetics for antibacterial coatings. Effective release is crucial for tailoring antibacterial implant longevity providing minimal inhibitory concentration (MIC) for the desired amount of time, which for oral implants, should be at least the cumulative time for the osseointegration period and functional loading period within the tissues. These parameters may differ between the implant type and its anatomical site. Also, the functional drug concentration in the peri-implant space should be calculated as the amount of the drug released from the implant surface including the concentration of the drug inactivated by biological fluids of the peri-implant space or saliva flow throughout the effective release time.

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Section: Antibacterial Biomaterials Active Surface Finishingmentioning

confidence: 99%

The paradigm shift for drug delivery systems for oral and maxillofacial implants

Pokrowiecki¹

2018

Drug Delivery

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“…7f). It was reported that the serious infiltration of inflammatory cells was mainly caused by bacterial infection rather than by the antimicrobial implants [72][73][74] . Overall, Ti-AMP-P3 and Ti-Dual-P4 rods have the best antimicrobial activity.…”

Section: Mfi Of Rgdmentioning

confidence: 99%

High-throughput screening and rational design of biofunctionalized surfaces with optimized biocompatibility and antimicrobial activity

et al. 2021

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Peptides are widely used for surface modification to develop improved implants, such as cell adhesion RGD peptide and antimicrobial peptide (AMP). However, it is a daunting challenge to identify an optimized condition with the two peptides showing their intended activities and the parameters for reaching such a condition. Herein, we develop a high-throughput strategy, preparing titanium (Ti) surfaces with a gradient in peptide density by click reaction as a platform, to screen the positions with desired functions. Such positions are corresponding to optimized molecular parameters (peptide densities/ratios) and associated preparation parameters (reaction times/reactant concentrations). These parameters are then extracted to prepare nongradient mono- and dual-peptide functionalized Ti surfaces with desired biocompatibility or/and antimicrobial activity in vitro and in vivo. We also demonstrate this strategy could be extended to other materials. Here, we show that the high-throughput versatile strategy holds great promise for rational design and preparation of functional biomaterial surfaces.

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“…Sunah Kang et al developed silicone implants that could reduce the fibrous capsule with a dense coating of 2-methacryloxyethyl phosphorylcholine (MPC) polymer. MPC is a zwitterionic polymer that mimics the head group of phosphatylcholine lipids in the plasma membrane and is widely applied as a coating material on orthopedic, cardiovascular, and ophthalmologic medical devices [ 80 , 81 ]. Heat-induced polymerization was applied for covalently grafted MPC around the silicone implant.…”

Section: Surface Modification Using Polymersmentioning

confidence: 99%

Functionalization of Silicone Surface with Drugs and Polymers for Regulation of Capsular Contracture

et al. 2021

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Breast reconstruction is achieved using silicone implants, which are currently associated with major complications. Several strategies have been considered to overcome the existing limitations as well as to improve their performance. Recently, surface modification has proved to be an effective clinical approach to prevent bacterial adhesion, reduce capsular thickness, prevent foreign body reactions, and reduce other implant-associated problems. This review article summarizes the ongoing strategies for the surface modification of silicone implants in breast reconstruction applications. The article mostly discusses two broad categories of surface modification: drug-mediated and polymer-based. Different kinds of drugs have been applied with silicone that are associated with breast reconstruction. Initially, this article discusses studies related to drugs immobilized on silicone implants, focusing on drug-loading methods and their effects on capsule contracture. Moreover, the pharmacological action of drugs on fibroblast cells is considered in this section. Next, the polymeric modification of the silicone surface is introduced, and we discuss its role in reducing capsule thickness at the cellular and biological levels. The polymeric modification techniques, their chemistry, and their physical properties are described in detail. Notably, polymer activities on macrophages and inflammation are also briefly discussed. Each of the reviewed articles is summarized, highlighting their discussion of capsular thickness, foreign body reactions, and bacterial attachment. The aim of this review is to provide the main points of some research articles regarding the surface modification of silicon, which can lead to a decrease in capsular thickness and provides better patient compliance.

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Anti-inflammatory and Antibacterial Effects of Covalently Attached Biomembrane-Mimic Polymer Grafts on Gore-Tex Implants

Cited by 45 publications

References 56 publications

The paradigm shift for drug delivery systems for oral and maxillofacial implants

The paradigm shift for drug delivery systems for oral and maxillofacial implants

High-throughput screening and rational design of biofunctionalized surfaces with optimized biocompatibility and antimicrobial activity

Functionalization of Silicone Surface with Drugs and Polymers for Regulation of Capsular Contracture

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