Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Wu, Ming‐Shun; Aquino, Levent Bless B.; Barbaza, Marjette Ylreb U.; Hsieh, Chieh Lun; Castro-Cruz, Kathlia A. De; Yang, Ling; Tsai, Po-Wei

doi:10.3390/molecules24244426

Cited by 93 publications

(59 citation statements)

References 157 publications

(173 reference statements)

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“…F. asafoetida is known to use for the treatment of respiratory problems, including bronchitis, asthma, and whooping coughs [ 39 ]. Additionally, these spice bioactives have exhibited several beneficial activities, including antifungal, antioxidant, hepatoprotective, anti-inflammatory, and have immune-boosting properties [ 16 , [38] , [39] , [40] , [41] , [42] ].…”

Section: Resultsmentioning

confidence: 99%

Culinary spice bioactives as potential therapeutics against SARS-CoV-2: Computational investigation

Natesh

Mondal

Penta

et al. 2021

Computers in Biology and Medicine

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Background Coronavirus disease-(COVID-19) is an infectious pandemic caused by SARS-CoV-2. SARS-CoV-2 main protease (M pro ) and spike protein are crucial for viral replication and transmission. Spike protein recognizes the human ACE2 receptor and transmits SARS-CoV-2 into the human body. Thus, M pro , spike protein, and ACE2 receptor act as appropriate targets for the development of therapeutics against SARS-CoV-2. Spices are traditionally known to have anti-viral and immune-boosting activities. Therefore, we investigated the possible use of selected spice bioactives against the potential targets of SARS-CoV-2 using computational analysis. Methods Molecular docking analysis was performed to analyze the binding efficiency of spice bioactives against SARS-CoV-2 target proteins along with the standard drugs. Drug-likeness properties of selected spice bioactives were investigated using Lipinski's rule of five and the SWISSADME database. Pharmacological properties such as ADME/T, biological functions, and toxicity were analyzed using ADMETlab, PASS-prediction, and ProTox-II servers, respectively. Results Out of forty-six spice bioactives screened, six bioactives have shown relatively better binding energies than the standard drugs and have a higher affinity with at least more than two targets of SARS-CoV-2. The selected bioactives were analyzed for their binding similarities with the standard drug, remdesivir, towards the targets of SARS-CoV-2. Selected spice bioactives have shown potential drug-likeness properties, with higher GI absorption rate, lower toxicity with pleiotropic biological roles. Conclusions Spice bioactives have the potential to bind with the specific targets involved in SARS-CoV-2 infection and transmission. Therefore, spice-based nutraceuticals can be developed for the prevention and treatment of COVID-19.

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Section: Resultsmentioning

confidence: 99%

Culinary spice bioactives as potential therapeutics against SARS-CoV-2: Computational investigation

Natesh

Mondal

Penta

et al. 2021

Computers in Biology and Medicine

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“…It then induces the transcription of pro-inflammatory mediators such as iNOS and COX-2. Several studies have shown that anti-inflammatory agents inhibit NF-κB activation by preventing IκB degradation [ 19 , 20 , 21 ]. Thus, we attempted to determine whether 4H-7MTC inhibits IκB phosphorylation and degradation.…”

Section: Resultsmentioning

confidence: 99%

4-Hydroxy-7-Methoxycoumarin Inhibits Inflammation in LPS-activated RAW264.7 Macrophages by Suppressing NF-κB and MAPK Activation

Kang

Hyun

2020

Molecules

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Coumarins are natural products with promising pharmacological activities owing to their anti-inflammatory, antioxidant, antiviral, anti-diabetic, and antimicrobial effects. Coumarins are present in many plants and microorganisms and have been widely used as complementary and alternative medicines. To date, the pharmacological efficacy of 4-hydroxy-7-methoxycoumarin (4H-7MTC) has not been reported yet. Therefore, in this study, we investigated the anti-inflammatory effects of 4H-7MTC in LPS-stimulated RAW264.7 cells as well as its mechanisms of action. Cells were treated with various concentrations of 4H-7MTC (0.3, 0.6, 0.9, and 1.2 mM) and 40 μM L-N6-(1-iminoethyl)-L-lysine (L-NIL) were used as controls. LPS-stimulated RAW264.7 cells showed that 4H-7MTC significantly reduced nitric oxide (NO) and prostaglandin E2 (PGE2) production without cytotoxic effects. In addition, 4H-7MTC strongly decreased the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2). Furthermore, 4H-7MTC reduced the production of proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. We also found that 4H-7MTC strongly exerted its anti-inflammatory actions by downregulating nuclear factor kappa B (NF-κB) activation by suppressing inhibitor of nuclear factor kappa B alpha (IκBα) degradation in macrophages. Moreover, 4H-7MTC decreased phosphorylation of extracellular signal-regulated kinase (ERK1/2) and c-Jun N-terminal kinase/stress-activated protein kinase (JNK), but not that of p38 MAPK. These results suggest that 4H-7MTC may be a good candidate for the treatment or prevention of inflammatory diseases such as dermatitis, psoriasis, and arthritis. Ultimately, this is the first report describing the effective anti-inflammatory activity of 4H-7MTC.

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“…Sesamol is a lignin isolated from sesame seeds [7]. Sesamol has many biological functions, which produce anti-inflammatory, antioxidant, and anti-tumor effects [10]. Studies have shown that sesamol could induce apoptosis in cancer cells and inhibit the effects of proliferation and autophagy in lung cancer and colon cancer [11].…”

Section: Discussionmentioning

confidence: 99%

“…Sesamol is a polyphenol lignan isolated from sesame seeds. Sesamol has shown multiple biologically active functions in animal and cellular disease models [10,11]. Sesamol alleviated the expression of inflammatory mediators by suppressing the nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

Sesamol Alleviates Airway Hyperresponsiveness and Oxidative Stress in Asthmatic Mice

Liou

Chen

et al. 2020

Antioxidants

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Sesamol, isolated from sesame seeds (Sesamum indicum), was previously shown to have antioxidative, anti-inflammatory, and anti-tumor effects. Sesamol also inhibited lipopolysaccharide (LPS)-induced pulmonary inflammatory response in rats. However, it remains unclear how sesamol regulates airway inflammation and oxidative stress in asthmatic mice. This study aimed to investigate the efficacy of sesamol on oxidative stress and airway inflammation in asthmatic mice and tracheal epithelial cells. BALB/c mice were sensitized with ovalbumin, and received oral sesamol on days 14 to 27. Furthermore, BEAS-2B human bronchial epithelial cells were treated with sesamol to investigate inflammatory cytokine levels and oxidative responses in vitro. Our results demonstrated that oral sesamol administration significantly suppressed eosinophil infiltration in the lung, airway hyperresponsiveness, and T helper 2 cell-associated (Th2) cytokine expressions in bronchoalveolar lavage fluid and the lungs. Sesamol also significantly increased glutathione expression and reduced malondialdehyde levels in the lungs of asthmatic mice. We also found that sesamol significantly reduced proinflammatory cytokine levels and eotaxin in inflammatory BEAS-2B cells. Moreover, sesamol alleviated reactive oxygen species formation, and suppressed intercellular cell adhesion molecule-1 (ICAM-1) expression, which reduced monocyte cell adherence. We demonstrated that sesamol showed potential as a therapeutic agent for improving asthma.

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Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Cited by 93 publications

References 157 publications

Culinary spice bioactives as potential therapeutics against SARS-CoV-2: Computational investigation

Culinary spice bioactives as potential therapeutics against SARS-CoV-2: Computational investigation

4-Hydroxy-7-Methoxycoumarin Inhibits Inflammation in LPS-activated RAW264.7 Macrophages by Suppressing NF-κB and MAPK Activation

Sesamol Alleviates Airway Hyperresponsiveness and Oxidative Stress in Asthmatic Mice

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