Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil

Abstract

Abstract:The oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition.

Research Article First cytotoxic, genotoxic, and antigenotoxic assessment of Euterpe oleracea fruit oil (açaí) in cultured human cells.

“…Favacho et al (2011) also reported the presence of the fatty acids, oleic, palmitic, and palmitoleic compounds as the major constituents of the açaí fruit oil. According to Del Pozo-Insfran et al (2004), the presence of bioactive substances, such as phenolic acids, flavonoids, and anthocyanins, attributes antioxidant properties and antitumorigenic potential to this fruit.…”

“…This fruit is also used in folk Brazilian medicine to treat anemia, diarrhea, malaria, pain, inflammation, hepatitis, and kidney diseases (Leão et al, 2007;Souza et al, 2011;Caetano et al, 2014;de Bem et al, 2014;Vásquez et al, 2014). Specific açaí fruit oil therapeutic potentials regarding anti-inflammatory, antinociceptive, and antidiarrheic activities were reported (Plotkin and Balick, 1984;Favacho et al, 2011).…”

Optimization of phenolic compounds extraction with antioxidant activity from açaí, blueberry and goji berry using response surface methodology

“…Fruits can be natural sources of antioxidants such as vitamins (Oliveira et al, 2011;Leong and Oey, 2012), carotenoids (Souza et al, 2014;Valdivielso et al, 2015) and phenolic compounds (Kang et al, 2012;Paz et al, 2015) with antioxidant properties (Castrejón et al, 2008;Koca and Karadeniz, 2009;Kang et al, 2012). The antioxidant activity of these compounds may act at different stages in the oxidation process, lowering free radicals concentration, chelating ions and even decomposing primary products and leading to nonradical compounds (Lobo et al, 2010;Perera et al, 2016) which help balance the immune system (Kang et al, 2012).…”

Genetic divergence among white-type acai palm accessions based on morpho-agronomic characters

“…is a perennial species that is widely distributed in the Amazon. Its natural habitat are the floodplains along the Amazon estuary in the state of Pará, Brazil, where it has several uses (Menezes et al, 2008;Favacho et al, 2011). Pará is the main producer and consumer of acai (Farias Neto et al, 2012), which is usually served as a drink obtained from fresh and in natura pulp extracted from the fruit.…”