Anti-Inflammatory and Antinociceptive Effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in Rodents

Abstract

The present work reports the anti-inflammatory and antinociceptive activities of the ethanol extract obtained from the stem bark of Sterculia striata A. St.-Hil. & Naudin (Ss-EtOH) in the experimental models of edema induced by carrageenan, dextran, or histamin and nociception induced by chemical stimuli, such as acetic acid, formalin, capsaicin, or glutamate. The Ss-EtOH (50 mg/kg) promoted a marked inhibition on the hind paw edema induced by carrageenan or dextran (30% and 73%, respectively). Besides, Ss-EtOH (25 mg/kg) exhibited a slight activity (30%) on the hind paw edema induced by histamin. The Ss-EtOH (12.5 and 25 mg/kg) showed the antinociceptive activity on chemical stimuli induced by acetic acid (65.59% and 38.37%, respectively), formalin, in the initial (35.08% and 31.5%, respectively) and late phases (44.09% and 83.57%, respectively), capsaicin (43.77% and 51.31%, respectively), or glutamate (36.6% and 52.12%, respectively). Regarding the possible mechanism involved in the antinociceptive effect, Ss-EtOH (12.5 mg/kg) showed a decrease in the antinociceptive effect (65.8%) in the acetic acid model after pretreatment with naloxone. Thus, opioid mechanisms might be underlying this response.

Anti-infective Properties of Brachychiton rupestris and Brachychiton luridum Leaves and their Qualitative Phytochemical Screening

“…The root bark and fruits of S. setigera are used to treat dysentery, syphilis, boils, and inflammation [35]. The leaves of S. striata together with hot butter or olive oil are used against boils and furuncles [7,36].…”

“…Malvaceae is a family of flowering plants with more than 200 genera and nearly 2300 species [6,7]. The family is composed mainly of tropical trees and shrubs with a few climbing and herbaceous species showing a wide array of medicinal values [6][7][8].…”

“…The family is composed mainly of tropical trees and shrubs with a few climbing and herbaceous species showing a wide array of medicinal values [6][7][8]. Brachychiton is a small genus belonging to family Malvaceae with approximately 30 species; native to Australia [9].…”

Sterculia and Brachychiton: a comprehensive overview on their ethnopharmacology, biological activities, phytochemistry and the role of their gummy exudates in drug delivery

“…Species from this family were subjected to intensive investigation due to the presence of different secondary metabolites with potent biological activity, such as triterpenes, flavonoids, alkaloids and coumarins. [2,3] Among the pharmacologically interesting genera are Sterculia and Brachychiton. They are related genera which were previously placed in the family Sterculiaceae.…”

Pharmacognosy, Phytochemical Study and Antioxidant Activity of Sterculia rubiginosa Zoll. Ex Miq. Leaves

“…In addition, it can be a description of quality standards that ensure that the simplicia as ingredients and medicinal products meet the requirements of Quality-Safety-Efficacy. 3 A variety of pharmacological activities of Sterculia such as anti-oxidant, 4 anti TB, 5 cytotoxic, 6 CNS depressant, 7 anti-inflammatory activity, 6 antibacterial and hemolitic activity, 8 antifungal, genotoxic, 9 antidiabetic, 10 anthelmintic, gastroprotective 11 and analgesic activity. 12 …”