Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis

Abstract

GbEE markedly demonstrated anti-inflammatory action in rats and antinociceptive activity in mice, which supports previous claims of the traditional use of species of the Garcinia genus for inflammation and pain.

An ethnopharmacological survey of the traditional medicine utilized in the community of Porvenir, Bajo Paraguá Indian Reservation, Bolivia

“…In vivo anti-inflammatory and antinociceptive effects of Garcinia brasiliensis have been described (Santa-Cecília et al, 2011). In vivo effects of Chenopodium ambrosoides on the gastrointestinal system have been reported (Calzada et al, 2010).…”

Growth curve, biochemical profile and phytochemical analyses in calli obtained from the procambium segments of Bacupari

“…Previous reports have demonstrated the presence of bioactive compounds in this plant, such as biflavonoids and prenylated xanthones and benzophenones (Delle Monache et al 1984;Santos et al 1999). Among the natural bioactive compounds, the polyisoprenylated benzophenones are associated with the biological activities such as anti-HIV (Gustafon et al 1992); leishmanicidal (Pereira et al 2010), free radical scavenger (Ngouela et al 2006), anti-cholinesterase (Lenta et al 2007), anti-inflammatory and antinociceptive (Santa-Cecília et al 2011). Three natural polyisoprenylated benzophenones have been isolated from Garcinia brasiliensis: Guttiferone-A (Gustafson et al 1992), 7-epiclusianone (Santos et al 1999) and Garciniaphenone (Derogis et al 2008).…”

“…Quantification was based on a standard curve of quercetin. High performance liquid chromatography (HPLC) analysis of the samples was performed on Shimadzu LC-20A equipment using a C18 NST column, Nano Separation Technologies (150 x 4.6 mm), with a 5 µm particle size according to Santa Cecília et al (2011). The mobile phases consisted of eluent A (0.5 mM L -1 aqueous acetic acid) and eluent B (methanol/acetic acid 0.1%).…”

Ocorrência de biflavonoides em Clusiaceae: aspectos químicos e farmacológicos

“…20 Espécies de Garcinia são ricas em derivados fenólicos oxigenados e prenilados, alguns destes exibindo várias atividades biológicas, tais como, antifúngicos, anti-inflamatórios e antioxidantes. 21 Os biflavonoides têm despertado o interesse devido à frequência e abundância com que são encontrados neste gênero e cuja diversidade estrutural é devida, principalmente, aos diferentes padrões de hidroxilação, glicosilação, metoxilação e sulfatação.…”

“…A ocorrência destes metabó-litos foi registrada em 32 espécies do gênero Garcinia (Tabela 1), totalizando cerca de 36 biflavonoides (Figura 1). Do gênero Garcinia foram isolados biflavonoides dos tipos GB1 (1-9), GB-1a (10-17), morelloflavona (18)(19)(20)(21)(22)(23)(24)(25)(26) C. inophylloide amentoflavona (27) piranoamentoflavona (31) 23 C. panciflorum GB1 (1) GB-1a (10) GB2 (3) GB-2a (13) garcinianina (40) pancibiflavonol (41) 30 C. pinetorum amentoflavona (27) 31 …”