Anti-inflammatory and antioxidant activities of<i>Jungia paniculata</i>

Bartolomé-Casado, Raquel; Landa, Amaya; Calvo, José Javier; Terencio, María del Carmen; Calvo, María Isabel

doi:10.3109/13880200903311128

Cited by 9 publications

(6 citation statements)

References 33 publications

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“…Previously, there was only one study by Casado et al (2010) demonstrating the anti-inflammatory and anti-oxidant effects of J. paniculata, using in vitro [NO production in RAW 264.7 macrophages and secretory phospholipase A2 (sPLA2) inhibition assay] and in vivo [carrageenan-induced paw oedema in rats and 12-O-tetradecanoylphorbol-13-acetato (TPA)-induced ear oedema in mice] experiments. Our research found that J. sellowii markedly inhibited leukocyte content, as well as the degree of exudation.…”

Section: Discussionmentioning

confidence: 99%

“…There are few pharmacological studies of anti-inflammatory effects of Jungia except for that described by Casado et al (2010), who demonstrated the anti-inflammatory and antioxidant effects of J. paniculata, a plant used as topical anti-inflammatory herb in traditional medicine in South America. In that study the effect of the herb was associated with the presence of polyphenols and flavonoids.…”

Section: Introductionmentioning

confidence: 99%

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Jungia sellowii suppresses the carrageenan-induced inflammatory response in the mouse model of pleurisy

et al. 2014

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This study was conducted to explore the anti-inflammatory effect of Jungia sellowii (Asteraceae) using a murine model of pleurisy induced by carrageenan (Cg). This plant is used in southern Brazil to treat inflammatory diseases. J. sellowii leaves were extracted with ethanol/water to obtain the crude extract (CE), which was fractionated with different solvents, yielding n-hexane (Hex), dichloromethane (DCM), ethyl acetate (EtOAc) and n-butanol (BuOH) fractions, and aqueous fraction (Aq). The major compounds succinic acid (SA) and lactic acid (LA) were isolated from Aq fraction, and their structures were determined by (1)H and (13)C NMR. Pleurisy was induced by Cg (Saleh et al. 1996). The leukocytes, exudation, myeloperoxidase (MPO) and adenosine-deaminase (ADA) activities, metabolites of nitric oxide (NO x ) levels, protein levels and mRNA expression for interleukin 1 beta (IL-1β), tumour necrosis factor alpha (TNF-α), interleukin 17A (IL17A) and inducible of nitric oxide synthase (iNOs), and p65 protein phosphorylation (NF-κB) were analysed 4 h after pleurisy induction. Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1β, TNF-α, and IL-17A levels, and the mRNA expression for IL-1β, TNF-α, IL-17A, iNOS, and p65 protein phosphorylation (NF-κB) (p < 0.05). Our study demonstrated that J. sellowii can protect against inflammation induced by Cg by decreasing the leukocytes and exudation. Its effects are related to the decrease of either proinflammatory cytokines and/or NO x . The isolated compounds SA and LA may play an important role in this anti-inflammatory action by inhibiting all the studied parameters. The anti-inflammatory properties of these compounds are due to the downregulation of NF-κB.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Jungia sellowii suppresses the carrageenan-induced inflammatory response in the mouse model of pleurisy

et al. 2014

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“…Species such as J. paniculata and J. polita are used in South America to disinfect and cure external wounds, to treat inflammation [ 1 – 2 ], and as a blood depurative [ 3 ]. Pharmacological studies demonstrated that the anti-inflammatory and antioxidant effects of J. paniculata were associated to the presence of flavonoids and other polyphenols [ 4 ]. Recently, we reported the in vivo anti-inflammatory properties of an aqueous fraction of the leaves of J. sellowii , that is in agreement with its popular use in Brazil [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Three new trixane glycosides obtained from the leaves of Jungia sellowii Less. using centrifugal partition chromatography

Azevedo

Faqueti

Kritsanida

et al. 2016

Beilstein J. Org. Chem.

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Summary Jungia sellowii (Asteraceae) is a shrub that grows in Southern Brazil and polar extract of its leaves presents anti-inflammatory properties. Cyperane, guaiane, nortrixane, and trixane sesquiterpene types were reported as the main metabolites in Jungia species. This work aims to describe the isolation and identification of sesquiterpenes in the leaves of J. sellowii using liquid–liquid partition and centrifugal partition chromatography. Thus, the crude extract of fresh leaves of J. sellowii was partitioned with hexane, dichloromethane, ethyl acetate and butanol, respectively. The butanol fraction was then subjected to a selected ternary system optimized for the CPC (centrifugal partition chromatography): ethyl acetate–ethanol–water (9:2:10, v/v/v). The separation was carried out isocratically at a flow rate of 25 mL/min at 1200 rpm, affording seven fractions A to G. TLC of fractions B, C and F displayed a single spot corresponding to three new glycosylated sesquiterpenoids. Their structures were established by using spectroscopic data in comparison to those reported in the literature. Furthermore, the isolates were evaluated for their leishmanicidal and cytotoxic effects. No cytotoxic effect was observed against the three cancer cell lines (HL60, JURKAT and REH), but compound 1 showed a weak antiprotozoal activity. Liquid–liquid partition and CPC turned to be a versatile technique of glycoside purification which is environmentally friendly and requires a limited amount of organic solvents.

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“…Inflammatory reaction is usually associated with reactive oxygen species which are mopped up by antioxidant. Also, antioxidant effects of E. speciosa will ameliorate oxidative stress which accompanies inflammatory conditions (Casado et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory and Anti-Nociceptive Properties of Hydro-Methanol Extract of Eremomastax Speciosa (Hochst.) Cufod Leaf

Onoja¹,

Eke²,

Ejiofo³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Eremomastax speciosa (Hochst.) Cufod is a perennial herb found in Africa along the rainforest zone and occurs as weed. It is cultivated in Cameroon and Akwa-Ibom in Nigeria due to its medicinal values. This study investigated the antioxidant, anti-inflammatory and antinociceptive properties of hydromethanol extract of Eremomastax speciosa (Hochst.) Cufod leaf in rat model. Materials and Methods: The plant material was extracted using cold maceration method in 80% hydromethanol. The acute oral toxicity test was performed using Up and Down method with limit dose of 2000 mg/kg. The in vitro antioxidant property was evaluated with 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power photometric assays. The anti-inflammatory potential was investigated in egg-albumin and carrageenan induced paw edema models while the antinociceptive activity was determined using acetic acid induced writhing reflex and tail immersion tests at the doses of 50, 100 and 200 mg/kg. The negative control group (group A) received distilled water (vehicle) at 5 ml/kg while acetyl salicylic acid (200 mg/kg) was used as the reference drug for the anti-inflammatory models and acetic acid induced writhing reflex model while pentazocine (5 mg/kg) was used as the reference drug for tail immersion test. Results: The LD 50 of the extract was greater than 2000 mg/kg. The extract (25 to 400 µg/ml) demonstrated potent antioxidant activities in both the 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power assays. The E. speciosa extract caused significant (P < 0.05) anti-inflammatory and antinociceptive activities in the extract treated groups when compared to rats that received distilled water. The optimal activities of the extract were produced at the dose of 100 mg/kg. Conclusion: The study supports the folkloric use of Eremomastax speciosa leaf in the management of pain and inflammatory conditions in traditional medicine.

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Anti-inflammatory and antioxidant activities ofJungia paniculata

Cited by 9 publications

References 33 publications

Jungia sellowii suppresses the carrageenan-induced inflammatory response in the mouse model of pleurisy

Jungia sellowii suppresses the carrageenan-induced inflammatory response in the mouse model of pleurisy

Three new trixane glycosides obtained from the leaves of Jungia sellowii Less. using centrifugal partition chromatography

Antioxidant, Anti-Inflammatory and Anti-Nociceptive Properties of Hydro-Methanol Extract of Eremomastax Speciosa (Hochst.) Cufod Leaf

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