Anti-inflammatory and Antioxidant Effect of Lycoperoside H against the 1,2-Dimethyl Hydrazine (DMH) Induced Colorectal Cancer in Rats

Qi, Xin; Liu, Yongjian

doi:10.5650/jos.ess22003

Cited by 3 publications

(3 citation statements)

References 45 publications

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“…Antioxidant enzymes, including SOD, serve as the primary line of endogenous antioxidant defense and are highly susceptible to oxidative damage from carcinogens. Agents that counteract the action of carcinogens suppress the activity of antioxidant enzymes and reduce the overproduction of free radicals, thereby restoring the redox balance [ 54 ]. Supplementation with OBG significantly decreased TBARS levels and the activity of GPx, GR, and SOD in animals with CRC.…”

Section: Discussionmentioning

confidence: 99%

Consumption of Feed Supplemented with Oat Beta-Glucan as a Chemopreventive Agent against Colon Cancerogenesis in Rats

Harasym,

Dziendzikowska,

Kopiasz

et al. 2024

Nutrients

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Colorectal cancer (CRC) accounts for 30% of all cancer cases worldwide and is the second leading cause of cancer-related deaths. CRC develops over a long period of time, and in the early stages, pathological changes can be mitigated through nutritional interventions using bioactive plant compounds. Our study aims to determine the effect of highly purified oat beta-glucan on an animal CRC model. The study was performed on forty-five male Sprague–Dawley rats with azoxymethane-induced early-stage CRC, which consumed feed containing 1% or 3% low molar mass oat beta-glucan (OBG) for 8 weeks. In the large intestine, morphological changes, CRC signaling pathway genes (RT-PCR), and proteins (Western blot, immunohistochemistry) expression were analyzed. Whole blood hematology and blood redox status were also performed. Results indicated that the histologically confirmed CRC condition led to a downregulation of the WNT/β-catenin pathway, along with alterations in oncogenic and tumor suppressor gene expression. However, OBG significantly modulated these effects, with the 3% OBG showing a more pronounced impact. Furthermore, CRC rats exhibited elevated levels of oxidative stress and antioxidant enzyme activity in the blood, along with decreased white blood cell and lymphocyte counts. Consumption of OBG at any dose normalized these parameters. The minimal effect of OBG in the physiological intestine and the high activity in the pathological condition suggest that OBG is both safe and effective in early-stage CRC.

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Section: Discussionmentioning

confidence: 99%

Consumption of Feed Supplemented with Oat Beta-Glucan as a Chemopreventive Agent against Colon Cancerogenesis in Rats

Harasym,

Dziendzikowska,

Kopiasz

et al. 2024

Nutrients

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“…Gastric, hepatic [143] Solanigroside P Gastric [132] Lycoperoside H Colorectal [144] 3. Steroidal (Glyco)Alkaloids: Classification…”

Section: (26)-trien-3β-olmentioning

confidence: 99%

“…Leukemia, histiocytic lymphoma, hepatocellular carcinoma [92] 16, 23-epoxy-22, 26-epimino-cholest22(N), 23, 25(26)-trien-3β-ol Gastric, hepatic [143] Solanigroside P Gastric [132] Lycoperoside H Colorectal [144] 3. Steroidal (Glyco)Alkaloids: Classification…”

Section: (6)-en-3β-ol-6al Glycosidesmentioning

confidence: 99%

The Therapeutic Value of Solanum Steroidal (Glyco)Alkaloids: A 10-Year Comprehensive Review

et al. 2023

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Steroidal (glycol)alkaloids S(G)As are secondary metabolites made of a nitrogen-containing steroidal skeleton linked to a (poly)saccharide, naturally occurring in the members of the Solanaceae and Liliaceae plant families. The genus Solanum is familiar to all of us as a food source (tomato, potato, eggplant), but a few populations have also made it part of their ethnobotany for their medicinal properties. The recent development of the isolation, purification and analysis techniques have shed light on the structural diversity among the SGAs family, thus attracting scientists to investigate their various pharmacological properties. This review aims to overview the recent literature (2012–2022) on the pharmacological benefits displayed by the SGAs family. Over 17 different potential therapeutic applications (antibiotic, antiviral, anti-inflammatory, etc.) were reported over the past ten years, and this unique review analyzes each pharmacological effect independently without discrimination of either the SGA’s chemical identity or their sources. A strong emphasis is placed on the discovery of their biological targets and the subsequent cellular mechanisms, discussing in vitro to in vivo biological data. The therapeutic value and the challenges of the solanum steroidal glycoalkaloid family is debated to provide new insights for future research towards clinical development.

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Anti-Atherosclerosis and Cardioprotective Effect of Lycoperoside H Against High-Fat Diet-Induced Atherosclerosis in Rats

Gao¹,

Feng²,

Lei³

et al. 2023

International J. of Pharmacology

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Anti-inflammatory and Antioxidant Effect of Lycoperoside H against the 1,2-Dimethyl Hydrazine (DMH) Induced Colorectal Cancer in Rats

Cited by 3 publications

References 45 publications

Consumption of Feed Supplemented with Oat Beta-Glucan as a Chemopreventive Agent against Colon Cancerogenesis in Rats

Consumption of Feed Supplemented with Oat Beta-Glucan as a Chemopreventive Agent against Colon Cancerogenesis in Rats

The Therapeutic Value of Solanum Steroidal (Glyco)Alkaloids: A 10-Year Comprehensive Review

Anti-Atherosclerosis and Cardioprotective Effect of Lycoperoside H Against High-Fat Diet-Induced Atherosclerosis in Rats

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