Anti-inflammatory and antioxidative properties of honey bee venom on Freund's Complete Adjuvant-induced arthritis model in rats

Koçyiğit, Abdurrahim; Güler, Eray Metin; Kaleli, Süleyman

doi:10.1016/j.toxicon.2019.02.016

Cited by 50 publications

(44 citation statements)

References 45 publications

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“…Adurrahim et al in 2019 studied the antioxidant activity of BV in rats with RA by measuring the plasma total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). The results showed that those rats with RA treated with BV increased their TAS levels and decreased TOS and OSI levels, not showing any difference between the group treated with high or low doses [126]. Moreover, the antioxidant activity has been demonstrated on induced gastric ulceration in rats.…”

Section: Antioxidant Activitymentioning

confidence: 90%

Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

2020

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Bee venom (BV) is usually associated with pain since, when humans are stung by bees, local inflammation and even an allergic reaction can be produced. BV has been traditionally used in ancient medicine and in acupuncture. It consists of a mixture of substances, principally of proteins and peptides, including enzymes as well as other types of molecules in a very low concentration. Melittin and phospholipase A2 (PLA2) are the most abundant and studied compounds of BV. Literature of the main biological activities exerted by BV shows that most studies focuses on the comprehension and test of anti-inflammatory effects and its mechanisms of action. Other properties such as antioxidant, antimicrobial, neuroprotective or antitumor effects have also been assessed, both in vitro and in vivo. Moreover, human trials are necessary to confirm those clinical applications. However, notwithstanding the therapeutic potential of BV, there are certain problems regarding its safety and the possible appearance of adverse effects. On this perspective, new approaches have been developed to avoid these complications. This manuscript is aimed at reviewing the actual knowledge on BV components and its associated biological activities as well as the latest advances on this subject.

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Section: Antioxidant Activitymentioning

confidence: 90%

Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

2020

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“…The study revealed some features of the action of ASA and P-ASA on the response of immune cells of rats with carrageenan-induced edema. The main feature of the effects of drugs was less pronounced compared to the control increase in both GRA and GRA% counts at the peak of inflammation, which is associated with the antiinflammatory pharmacological effect of ASA, including the suppressive effect on immune cells neutrophils 24 , which are most rapidly activated in response on the injection of an antigen. In the groups that were administered with ASA, 24 h after administration of carrageenan, when the effect of the drug disappears, the number of neutrophils either continues to increase or remains elevated.…”

Section: Influence Of Preparations On Catalase Activity and Malondialmentioning

confidence: 84%

“…It was shown that inflammatory reactions and the action of anti-inflammatory substances might correlate with changes in the state of the pro / antioxidant system 22,23,24 . In this regard, the dynamics of changes in the malondialdehyde level in the blood serum, a parameter characterizing oxidative processes, namely, the intensity of lipid peroxidation and the activity of catalase, an enzyme that protects cells from free radicals and characterizes the state of the endogenous antioxidant system, was studied.…”

Section: Influence Of Preparations On Catalase Activity and Malondialmentioning

confidence: 99%

“…Analyzing the results obtained for catalase activity in the groups that were injected with P-ASA, it can be concluded that the complexation of pectin with ASA reduced the effect of ASA on the antioxidant catalase enzyme: on a decrease in its activity at the peak of inflammation and on an increase in its activity after 24 h later on administration, which is especially noticeable at a low dose of P-ASA of 100 mg/kg. In reports 24,28,29 , changes in the level of cytokines TNFα, IL-6, IL-1β, IL-8 are mentioned in conjunction with the study of the intensity of inflammatory reactions.…”

Section: Influence Of Preparations On Catalase Activity and Malondialmentioning

confidence: 99%

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2020

IJPSR

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The aim of this work is a comparison of antiinflammatory properties of the molecular pectin complex with 10% acetylsalicylic acid (P-ASA) and acetylsalicylic acid (ASA) in equimolar doses on the model of carrageenan-induced paw edema of rats. The study was carried out on a total of 28 adult male Sprague Dawley rats at 7 months of age. 30 min after injection of 1% aqueous solution of carrageenan to the plantar aponeurosis, studied drugs were orally administered once at the doses of 10, 20, 40 mg/kg ASA and 100, 200, 400 mg/kg P-ASA. The severity of edema, pain sensitivity, leukocyte count, its subpopulation ratio and IL-1β, IL-6, IL-8, TNFα level were determined. Normality, t-test and Mann-Whitney tests were used for statistical analyses. The ulcerogenic effect of P-ASA (dose 400 mg/kg) is significantly less than that of ACA (dose 40 mg/kg). The analgesic effect of P-ASA is comparable to ASA at equimolar doses. The anti-edema effect of ASA at the doses of 10 and 20 mg/kg is more pronounced than that of P-ASA at equimolar doses. P-ASA contributes to normalization of blood leukocyte profile. P-ASA may be recommended to using as anti-inflammatory agent with low ulcerogenic properties. INTRODUCTION: Studies in the development of anti-inflammatory drugs confirm their high relevance and take place in novel world literature 1, 2 .

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“…It has been reported that wasp venom contains a number of bioactive molecules, including amines, small peptides, and even enzymes, allergens, and toxins of high molecular mass [43]. What makes WV different from BV is that BV mainly has anti-inflammatory, antioxidative, and analgesic effects on RA, and it contains a variety of different peptides, including melittin, phospholipase A2, apamin, and so on [44]. e mechanisms for treating RA with these two venoms may be different and are worth further study.…”

Section: Discussionmentioning

confidence: 99%

Wasp Venom Possesses Potential Therapeutic Effect in Experimental Models of Rheumatoid Arthritis

Gao

Duan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Rheumatoid arthritis (RA) is an autoimmune disease. Wasp venom (WV), which is considered as a traditional folk medicine in Jingpo nationality in Yunnan, China, relieves rheumatoid arthritis. The current study aimed to investigate the effect of wasp venom ameliorating rheumatoid arthritis symptoms in experimental rats. We established a model of type II collagen- (CII-) induced arthritis (CIA) in SD rats and examined the inhibition of inflammation and autoimmune response. The antiarthritic effects of WV were evaluated through the paw swelling, and histopathological score and histopathology changes of the affected paw were assessed. The anti-inflammation effects were assayed by the level of IL-6, TNF-α, IL-1β, and the number of inflammatory cells in peripheral blood. The alteration of the T cell subset ratio in the spleen of rats was detected by flow cytometry, and at the same time, the viscera index and immune serum globulin levels were evaluated. The results suggested that various doses of WV (0.125, 0.25, and 0.5 mg/kg) significantly alleviated paw swelling and arthritis score in CIA rats with the untreated control (P<0.05). WV (0.25 and 0.5 mg/kg) relieved synovial tissue lesions of ankle joints and histopathology scores of synoviocyte hyperplasia and inflammatory cell infiltration with vehicle group (P<0.05). Regarding immunological regulation, 0.5 mg/kg WV lowered the immune serum globulin levels (P<0.05), and we further found that WV (0.5 mg/kg) suppressed the immune response of Th cells, while enhancing the functions of Tc cells and Treg cells in spleen cells markedly (P<0.05). The immunosuppressive action of WV displayed was analogous to its inhibitory effect on IL-1β, TNF-α, IL-8, IL-6, COX-2, and PGE2 levels in rat serum. In conclusion, these findings demonstrated that WV exhibited antiarthritic activity, which might be associated with their inhibitory effects on immunoregulation and anti-inflammatory action.

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Anti-inflammatory and antioxidative properties of honey bee venom on Freund's Complete Adjuvant-induced arthritis model in rats

Cited by 50 publications

References 45 publications

Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

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Wasp Venom Possesses Potential Therapeutic Effect in Experimental Models of Rheumatoid Arthritis

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