Anti‐Inflammatory and Neuroprotective Effects of Standardized Fractions in Herniarin and Daphnoretin from <i>Distictis buccinatoria</i>

Porras-Dávila, Sandra Liliana; Zamilpa, Alejandro; Jiménez-Ferrer, Enrique; Jiménez–Aparicio, Antonio Ruperto; Santillán-Urquiza, Mayra Alejandra; Díaz-Patricio, Fernanda; Herrera-Ruíz, Maribel

doi:10.1002/cbdv.202200969

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Hernianin, or 7-methoxycoumarin, was found in substantial amounts in the fruits [11] . It has been found to have cytotoxic and anti-inflammatory activities [33,34] .…”

Section: Other Secondary Metabolitesmentioning

confidence: 99%

Active compounds and biological activities of Hypericum androsaemum L.: A review

Aguiar,

Costa

2023

J Pharmacogn Phytochem

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Hypericum androsaemum L. is a plant renowned in the Mediterranean basin for diuretic, hepatoprotective, anti-hypertensive, anti-hemorrhoidal, anti-depressant and skin-protective effects. This review makes a critical summary of published pharmacognostical data. H. androasemum contains significant amounts of phenolic compounds, namely chlorogenic acids, flavonoids, triterpenoids, polycyclic polyprenylated acylphloroglucinols (PPAPs) and xanthones. Extracts of the plant have shown radical scavenging activity. The fruits' extracts have shown cytotoxic activity against some cancer cell lines. The plant has some immunomodulatory, DNA-protective, anti-glycation, antidepressant and antiinflammatory effects. Given its effect on fibroblasts proliferation and migration, collagenase and tyrosinase inhibitory action, immunomodulatory effect, UV-protective and lack of phototoxicity, it has potential in skin formulas. It has shown biocidal activity against some bacteria, fungi, nematodes, mollusks and insects. At low concentrations, the extracts were nontoxic on normal cells. However, safety issues may arise with oral administration of high hyperforin H. androasemum preparations.

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“…Hernianin, or 7-methoxycoumarin, was found in substantial amounts in the fruits [11] . It has been found to have cytotoxic and anti-inflammatory activities [33,34] .…”

Section: Other Secondary Metabolitesmentioning

confidence: 99%

Active compounds and biological activities of Hypericum androsaemum L.: A review

Aguiar,

Costa

2023

J Pharmacogn Phytochem

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“…Recent research has shown that different extracts of T. lucida have properties such as anti-inflammatory and antioxidant activities and mainly have a potential use against illnesses related to the CNS, providing antinociceptive and sedative effects, and treatment for disorders of depression and anxiety [17][18][19]21,23,[25][26][27][28][29]. The HPLC analysis of the TlHx and TlAcOEt extracts allowed the identification of five coumarins with biological activity: IC, HN, DF, SC, and PE.…”

Section: Quantification and Chemical Identification Of Five Coumarinsmentioning

confidence: 99%

Effects of Five Coumarins and Standardized Extracts from Tagetes lucida Cav. on Motor Impairment and Neuroinflammation Induced with Cuprizone

Castro-Martínez,

Herrera-Ruiz,

González-Cortázar

et al. 2023

Pharmaceuticals

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Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) with no curative treatment, and the available therapies aim to modify the course of the disease. It has been demonstrated that extracts of Tagetes lucida have immunomodulatory and neuroprotective effects. This work induced motor damage and neuroinflammation in male BALB/c mice by oral administration of cuprizone (CPZ) (40 mg/kg) for five weeks. In addition, the extracts and coumarins of Tagetes lucida (25 mg/kg) were used to control these damage variables; during the experiment, animals were subject to behavioral tests, and at the end of 5 weeks, mice from each group were used to measure the integrity of biological barriers (brain, kidneys, and spleen) through the extravasation test with blue Evans dye. In another group of animals, the ELISA method measured the brain concentrations of IL-1β, IL-4, IL-10, and TNF-α. The results presented here allow us to conclude that the extracts and coumarins IC, HN, PE, DF, and SC of Tagetes lucida exert a neuroprotective effect by controlling the motor damage and neuroinflammation by increasing the expression of IL-4 and IL-10 and decreasing IL-1β and TNF-α; notably, these treatments also protect organs from vascular permeability increase, mainly the BBB, in mice with CPZ-induced experimental encephalomyelitis (VEH * p < 0.05). However, more studies must be carried out to elucidate the molecular mechanisms of the pharmacological effects of this Mexican medicinal plant.

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Herniarin ameliorates acrylamide-induced neurotoxicity in rat: involvement of neuro-inflammation and acetylcholinesterase

Mirzavi,

Rajabian,

Hosseini

et al. 2024

Natural Product Research

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Anti‐Inflammatory and Neuroprotective Effects of Standardized Fractions in Herniarin and Daphnoretin from Distictis buccinatoria

Cited by 4 publications

References 35 publications

Active compounds and biological activities of Hypericum androsaemum L.: A review

Active compounds and biological activities of Hypericum androsaemum L.: A review

Effects of Five Coumarins and Standardized Extracts from Tagetes lucida Cav. on Motor Impairment and Neuroinflammation Induced with Cuprizone

Herniarin ameliorates acrylamide-induced neurotoxicity in rat: involvement of neuro-inflammation and acetylcholinesterase

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