Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoids

Gallego, Rocío; Valdés, Alberto; Suárez-Montenegro, Zully Jimena; Sánchez-Martínez, José David; Cifuentes, Alejandro; Ibáñez, Elena; Herrero, Miguel

doi:10.1016/j.algal.2022.102830

Cited by 17 publications

(16 citation statements)

References 50 publications

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“…Additionally, CPP 1–3 kDa significantly lowers the expression of IL-1β in LPS-induced RAW264.7 cell lines. In line with our results, carotenoid-enriched microalgae extract of H. pluvialis , P. cruentum, T. lutea, and N. oceanica also reduced the antioxidant and anti-inflammatory stress in human neuroblastoma cell line SH-SY5Y [ 55 ]. The previous report has revealed that ethanol extract of Nannochloropsis oceanica (N. oceanica) at 20 μg/mL concentration downregulated the nitric oxide synthesis, NF-κB and β-secretase activity in LPS-induced BV2, RAW264.7, and neuronal cells [ 56 ].…”

Section: Discussionsupporting

confidence: 85%

“…The Aβ induces oxidative stress and causes mitochondrial dysfunction resulting in decreased intracellular ATP levels. In a seminal study, using MTT assay of carotenoids-enriched extracts from microalgae Haematococcus pluvialis , Porphyridium cruentum , Nannochloropsis oceanica and Tisochrysis lutea on Tubular epithelial cells (HK-2), human THP-1 monocytes and human SH-SY5Y neuroblastoma cell lines reported that only H. pluvialis and T. lutea extract at 100 μg/mL are toxic to HK-2 cell line while all the microalgae extracts were found not cytotoxic for any cell lines at concentrations ranging from 25 to 50 μg/mL [ 55 ]. These results indicate a safer profile of CPP as well as other microalgae extracts for the neuronal cell line.…”

Section: Discussionmentioning

confidence: 99%

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Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease

Wang¹,

Chuu²,

Lee³

et al. 2023

Heliyon

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease

Wang¹,

Chuu²,

Lee³

et al. 2023

Heliyon

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“…Microalgae extracts were shown to have a medium and specific cholinergic inhibitory activity, as well as significant antioxidant and anti-inflammatory capabilities, with particular emphasis on the extracts of N. oceanica and T. lutea . These findings were published by Gallego et al [ 62 ].…”

Section: Carotenoids As Anti-apoptotic Agentsupporting

confidence: 82%

Carotenoids: Role in Neurodegenerative Diseases Remediation

Gandla¹,

Babu

Unnisa

et al. 2023

Brain Sciences

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Numerous factors can contribute to the development of neurodegenerative disorders (NDs), such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis. Oxidative stress (OS), a fairly common ND symptom, can be caused by more reactive oxygen species being made. In addition, the pathological state of NDs, which includes a high number of protein aggregates, could make chronic inflammation worse by activating microglia. Carotenoids, often known as “CTs”, are pigments that exist naturally and play a vital role in the prevention of several brain illnesses. CTs are organic pigments with major significance in ND prevention. More than 600 CTs have been discovered in nature, and they may be found in a wide variety of creatures. Different forms of CTs are responsible for the red, yellow, and orange pigments seen in many animals and plants. Because of their unique structure, CTs exhibit a wide range of bioactive effects, such as anti-inflammatory and antioxidant effects. The preventive effects of CTs have led researchers to find a strong correlation between CT levels in the body and the avoidance and treatment of several ailments, including NDs. To further understand the connection between OS, neuroinflammation, and NDs, a literature review has been compiled. In addition, we have focused on the anti-inflammatory and antioxidant properties of CTs for the treatment and management of NDs.

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“…Furthermore, the serum concentrations of IL-6 and TNF-α were reduced. This effect was attributed to the bioactivity of carotenoids in N. gaditana [ 191 , 192 ].…”

Section: Effect Of Microalgae On Diabetes Mellitusmentioning

confidence: 99%

Therapeutic Potentials of Microalgae and Their Bioactive Compounds on Diabetes Mellitus

Tamel Selvan,

Goon,

Makpol

et al. 2023

Marine Drugs

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Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or both. Oxidative stress and chronic low-grade inflammation play crucial roles in the pathophysiology of diabetes mellitus. There has been a growing interest in applying natural products to improve metabolic derangements without the side effects of anti-diabetic drugs. Microalgae biomass or extract and their bioactive compounds have been applied as nutraceuticals or additives in food products and health supplements. Several studies have demonstrated the therapeutic effects of microalgae and their bioactive compounds in improving insulin sensitivity attributed to their antioxidant, anti-inflammatory, and pancreatic β-cell protective properties. However, a review summarizing the progression in this topic is lacking despite the increasing number of studies reporting their anti-diabetic potential. In this review, we gathered the findings from in vitro, in vivo, and human studies to discuss the effects of microalgae and their bioactive compounds on diabetes mellitus and the mechanisms involved. Additionally, we discuss the limitations and future perspectives of developing microalgae-based compounds as a health supplement for diabetes mellitus. In conclusion, microalgae-based supplementation has the potential to improve diabetes mellitus and be applied in more clinical studies in the future.

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Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoids

Cited by 17 publications

References 50 publications

Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease

Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease

Carotenoids: Role in Neurodegenerative Diseases Remediation

Therapeutic Potentials of Microalgae and Their Bioactive Compounds on Diabetes Mellitus

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