Anti-Inflammatory and Protective Effects of Water Extract and Bioferment from Sambucus nigra Fruit in LPS-Induced Human Skin Fibroblasts

Wójciak–Kosior, Magdalena; Ziemlewska, Aleksandra; Zagórska‐Dziok, Martyna; Nizioł–Łukaszewska, Zofia; Szczepanek, Dariusz; Oniszczuk, Tomasz; Sowa, Ireneusz

doi:10.3390/ijms241210286

Cited by 4 publications

(1 citation statement)

References 58 publications

(71 reference statements)

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“…Similarly, silver nanoparticles (AgSNs) of an extract of elderberries diminished the viability of dysplastic oral keratinocytes (DOKs), while they stimulated the proliferation of human gingival fibroblasts (HGFs) [36]. In addition, a water extract of elderberries potentiated the activity of keratinocytes but slightly inhibited the viability of fibroblasts, indicating that elderberries may be helpful in the prevention of some skin conditions [37]. Thus, an extract of elderberries was found to decrease the proliferation of murine B16-F10 melanoma and human SH-SY5Y neuroblastoma cells [38].…”

Section: Development Of Potential Therapeutic Agents From Elderberriesmentioning

confidence: 99%

Development of Potential Therapeutic Agents from Black Elderberries (the Fruits of Sambucus nigra L.)

Ren,

Meyer,

Anderson

et al. 2024

Molecules

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Elderberry (Sambucus nigra L.) is a widespread deciduous shrub, of which the fruits (elderberries) are used in the food industry to produce different types of dietary supplement products. These berries have been found to show multiple bioactivities, including antidiabetic, anti-infective, antineoplastic, anti-obesity, and antioxidant activities. An elderberry extract product, Sambucol®, has also been used clinically for the treatment of viral respiratory infections. As the major components, phenolic compounds, such as simple phenolic acids, anthocyanins and other flavonoids, and tannins, show promising pharmacological effects that could account for the bioactivities observed for elderberries. Based on these components, salicylic acid and its acetate derivative, aspirin, have long been used for the treatment of different disorders. Dapagliflozin, an FDA-approved antidiabetic drug, has been developed based on the conclusions obtained from a structure–activity relationship study for a simple hydrolyzable tannin, β-pentagalloylglucoside (β-PGG). Thus, the present review focuses on the development of therapeutic agents from elderberries and their small-molecule secondary metabolites. It is hoped that this contribution will support future investigations on elderberries.

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Section: Development Of Potential Therapeutic Agents From Elderberriesmentioning

confidence: 99%

Development of Potential Therapeutic Agents from Black Elderberries (the Fruits of Sambucus nigra L.)

Ren,

Meyer,

Anderson

et al. 2024

Molecules

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Effect of hydroalcoholic extract of Sambucus nigra on superficial digital flexor tendon repair in rabbit by ultrasonography and histopathology

Asgari,

Moghtadaei‐Khorasgani,

Yadegari

et al. 2024

Veterinary Medicine & Sci

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BackgroundAdult tendon tissue has limited and slow regenerative capacity. Sambucus nigra plant possesses antioxidant and anti‐inflammatory attributes.ObjectivesThis study aimed to evaluate the effect of hydroalcoholic extract of this plant's fruit on superficial digital flexor tendon repair in rabbits (SDFT).MethodsTwenty‐five male New Zealand white rabbits weighing 1.5–2 kg were selected, quarantined and randomly divided into four groups of six. By performing a partial left posterior limb tenotomy, differentiating the SDFT and creating multiple scrapes were performed. During 3 consecutive days post‐surgery, the positive control group was injected with 0.5 mg/kg dexamethasone, whereas the treatment groups received extract doses of 200 and 400 mg/kg, respectively. The negative control group did not receive any medication. Evaluation of sonographic and histopathological parameters was conducted on days 0, 7 and 28 post‐surgeries. Findings were analysed and compared using SPSS22.ResultsBoth treatment groups showed significant differences in echogenicity, and collagen fibre alignment compared to the control and positive control groups, in sonographic evaluation. Histopathological examination revealed fewer inflammatory cells and increased collagen fibre formation in the treatment groups compared to the other two groups. No significant difference in angiogenesis was observed among the groups on days 7 and 28 (p value <0.05).ConclusionsThe results indicate that the S. nigra fruit extract, by stimulating collagen synthesis and reducing inflammation, effectively accelerates the healing process of injured tendons.

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VOLKSMED Database: A Source for Forgotten Wound Healing Plants in Austrian Folk Medicine

Eichenauer,

Saukel,

Glasl

2024

Planta Med

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The global increase in the incidence of wounds is concerning and fuels the search for new treatment options. The use of traditional medicinal plants in wound healing represents an appreciated available therapeutic possibility. This work introduces the VOLKSMED database, which contains plants and other materials used in Austrian folk medicine, either as monographs or mixtures. This work focuses on the monographs of the database. Concerning wound healing, Hypericum sp., Arnica montana, Calendula officinalis, Plantago sp., and Malva sp. are the most commonly used plants. The focus of this paper is set on selected lesser-known plants (Abies alba, Anthyllis vulneraria, Brassica sp., Gentiana sp., Larix decidua, Picea abies, Sambucus sp., Sanicula europaea) and their status quo in literature concerning wound healing. A systematic search using the databases SciFinder, SCOPUS, and PubMed yielded substantial evidence for the wound healing potential of Brassica sp., Gentiana sp., the Pinaceae A. abies, L. decidua, and P. abies, as well as Sambucus nigra. In vivo and clinical studies substantiate their use in Austrian folk medicine. According to the literature, especially A. vulneraria, Sambucus racemosa, and S. europaea would be worth investigating in-depth since data concerning their wound healing effects – even though scarce – are convincing. In conclusion, the VOLKSMED database contains promising opportunities for further treatment options in the field of wound healing. Future research should consider the listed plants to support their traditional use in Austrian folk medicine and possibly promote the implementation of old knowledge in modern medicine.

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Anti-Inflammatory and Protective Effects of Water Extract and Bioferment from Sambucus nigra Fruit in LPS-Induced Human Skin Fibroblasts

Cited by 4 publications

References 58 publications

Development of Potential Therapeutic Agents from Black Elderberries (the Fruits of Sambucus nigra L.)

Development of Potential Therapeutic Agents from Black Elderberries (the Fruits of Sambucus nigra L.)

Effect of hydroalcoholic extract of Sambucus nigra on superficial digital flexor tendon repair in rabbit by ultrasonography and histopathology

VOLKSMED Database: A Source for Forgotten Wound Healing Plants in Austrian Folk Medicine

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