Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant Nymphoides indica in Human Keratinocytes

Kim, You Ah; Kim, Dong Hee; Park, Chae Bin; Park, Tae-Soon; Park, Byoung Jun

doi:10.3390/molecules23092342

Cited by 18 publications

(16 citation statements)

References 45 publications

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“…In addition, botanical extracts have been shown to prevent or alleviate skin wrinkles caused by the secretion of inflammatory cytokines while promoting collagen production. Therefore, based on our results, we hypothesize that V. uliginosum extract effectively prevents skin photoaging by reducing the production of MMPs [35][36][37].…”

Section: Discussionmentioning

confidence: 67%

An Anthocyanin-Enriched Extract from Vaccinium uliginosum Improves Signs of Skin Aging in UVB-Induced Photodamage

Bae

Cho

et al. 2020

Antioxidants

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Accumulating evidence indicates that botanical extracts affect skin biophysical parameters, such as hydration, transepidermal water loss (TEWL), melanin index, erythema index, and wrinkle development. Vaccinium uliginosum extract contains a high level of anthocyanins as antioxidant and is ideal for use in dietary skin care products. Here, we assessed the photoprotective effects of dietary V. uliginosum extract in ultraviolet B (UVB)-irradiated hairless mice. Quantitative analysis of anthocyanin composition in the ethanol-extracted V. uliginosum sample was performed using high-performance liquid chromatography (HPLC). Skin parameter analysis and hematoxylin and eosin (H&E) staining were conducted on skin samples from UVB-irradiated hairless mice to evaluate the effects of V. uliginosum extract on skin conditions. In addition, skin mRNA and protein expression were assessed to characterize the molecular mechanisms underlying the effects of the anthocyanin-enriched extract on skin appearance and condition. Administration of the ethanol-extracted V. uliginosum sample caused significant changes in skin water-holding capacity, TEWL, wrinkle-related parameters, and epidermal thickness in UVB-irradiated hairless mice. In addition, oral administration of V. uliginosum attenuated the gene expression of matrix metalloproteinase (MMP) and increased levels of tissue inhibitor of metalloproteinase (TIMP) and antioxidant-related genes. Further, V. uliginosum administration downregulated inflammatory cytokine levels and UVB-induced phosphorylation of extracellular signaling regulated kinase (ERK), as well as Jun N-terminal kinase (JNK) and p38 protein levels. Oral administration of anthocyanin-enriched V. uliginosum extract can improve the appearance and condition of the skin following UV irradiation.

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Section: Discussionmentioning

confidence: 67%

An Anthocyanin-Enriched Extract from Vaccinium uliginosum Improves Signs of Skin Aging in UVB-Induced Photodamage

Bae

Cho

et al. 2020

Antioxidants

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“…Although the pathogenesis of ACD is not fully known, multiple studies reported that inflammatory and pruritic mediators are involved in the progress of ACD ( Nedoszytko et al., 2014 ). T helper (Th) 2 cytokines are typical inflammatory mediators in ACD ( Kim et al., 2018 ). In addition, recruitment of nerve growth factor (NGF) and interleukin (IL)-31 induces severe itching in ACD ( Feld et al., 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative and Synergic Effects of Derma-H, a New Herbal Formula, on Allergic Contact Dermatitis

Kim

Lee

et al. 2020

Front. Pharmacol.

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Allergic contact dermatitis (ACD) is characterized by itching, skin inflammation, and allergic responses caused by release of immunoglobulin E and T helper 2-specific cytokines. The aim of this study is to investigate the ameliorative and synergic effects of herbal formula, Derma-H, containing Astragalus membranaceus Fisch. ex Bunge (AM) and Nepeta tenuifolia Benth (NT) which have been used as traditional medicinal herbs for the cure of dryness, edema, and pruritus. 2,4-Dinitrochlorobenzene (DNCB) was applied for ACD induction. AM, NT, and a mixture of AM and NT was topically applied to skin lesions for 11 days. Dermatitis score and number of scratches were significantly diminished in AM, NT, and AM + NT (Derma-H)-treated groups. Especially, Derma-H was more effective than single treatment of AM and NT on skin hyperplasia and mast cell infiltration. Also, NGF expression decreased by NT and a mixture of AM and NT. Additionally, series of TrkA, Raf-1, MEK, and ERK were significantly inhibited by topical AM and NT application. Those findings suggested AM and NT treatment has a synergic effect on DNCB-induced ACD in mice.

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“…Flavonoids are polyphenols largely spread in plants, which are ingredients in fruits, herbal medicines and teas [7]. Quercetin 3,7-dimethyl ether 4'-glucoside isolated from the aquatic plant Nymphoides indica [8], puerarin V, an isoflavone isolated from the Chinese herb Kudzu (Pueraria spp.) root [9] and pilloin, from the stem barks of Aquilaria sinensis [7] showed anti-inflammatory activity in diverse models.…”

mentioning

confidence: 99%

“…root [9] and pilloin, from the stem barks of Aquilaria sinensis [7] showed anti-inflammatory activity in diverse models. For example, the effect of quercetin 3,7-dimethyl ether 4'-glucoside on diverse inflammatory markers after ultraviolet B irradiation of keratinocytes (HaCaT) was evaluated [8]. The authors reported that this flavonoid could inhibited p38, JNK, ERK (extracellular-signal-regulated kinase) and IκBα phosphorylation and inhibits the NF-κB expression.…”

mentioning

confidence: 99%

“…In addition, the compound enhanced the activation of skin barrier factors such as filaggrin, involucrin, loricrin and hyaluronic acid synthase-1 (HAS-1) upregulating the expression of these proteins and enzyme. According to these results, the authors [8] suggested that quercetin 3,7-dimethyl ether 4'-glucoside is essential for retaining water and maintaining intercellular space playing an important role in skin moisture retention.…”

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confidence: 99%

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Editorial to Special Issue—Anti-Inflammatory Activity of Natural Products

Miguel

2020

Molecules

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Inflammation involves several steps to respond to harmful stimuli. Plants, plant products, marine compounds, mushrooms and bee products (honey, propolis, bee pollen) have been a target of study in order to find effective anti-inflammatory compounds of natural origin. This Special Issue aims at unravelling some mechanisms involved in the anti-inflammatory activity of some phenols, terpenes and alkaloids among other secondary metabolites, isolated predominantly from plants and mushrooms.Kong et al. studied the anti-inflammatory activity of 5-HMF (5-hydroxymethylfurfural) in lipopolysaccharide-stimulated RAW 264.7 cells as well as the mechanisms involved in this action. 5-HMF that occurs in various food products, such as coffee, dried fruits, honey and fruit juices and results from an acid-catalyzed thermal dehydration of fructose in a heterocyclic Maillard reaction, was able to inhibit the production of nitric oxide (NO), prostagandin E2 (PGE2), tumor necrosis factor -α (TNF-α), interleukin-6 (IL-6), IL-1, reactive oxygen species (ROS) by suppressing the protein phosphorylation of MAPK (mitogen activated protein kinases), NF-κB (nuclear factor-κB) and Akt/mTOR (Serine/Threonine kinase / mamalian target of rapamycin) signal pathways in lipopolysaccahride (LPS)-stimulated RAW264.7 macrophage cells [1].Szebeni et al. studied the anti-inflammatory action of synthetic curcumin analogs, in order to improve the poor bioavailability of curcumin extracted from turmeric that also shows anti-inflammatory activity but without clinical application. The results showed that the curcumin analogs N-((E)-5-(3,5dihydroxyphenyl)-2-((E)-3-(3,5-dihydroxyphenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acetamide and N-((E)-5-(3-hydroxyphenyl)-2-((E)-3-(3-hydroxyphenyl) acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acr ylamide in rat models of TNBS [(2,4,6-trinitrobenzenesulphonic acid)]-induced colitis were able to reduce tissue destruction as well as the inflammatory conditions of submucosal layers, the severity of colonic inflammation and colonic myeloperoxidase (MPO) enzyme activity. The authors also reported that the induction of NF-κB by LPS, Escherichia coli O111:B4 in an NF-κB -driven luciferase expressing reporter cell line, was inhibited by those curcumin analogs on a concentration-dependent manner. N-((E)-5-(3-hydroxyphenyl)-2-((E)-3-(3-hydroxyphenyl) acryloyl)-3oxo-1-phenylpent-4-en-1-yl)acrylamide also inhibited the expression of TNF-α, (IL-6), IL-4 in peripheral blood mononuclear cells (PBMCs) after LPS stimulation [2].Wang et al. revealed that erinacine C, a cyathane type diterpenoid, extracted from Hericium erinaceus fungus that is consumed by Chinese and Japanese people, is able to induce the synthesis of nerve growth factor and has anti-inflammatory activity, particularly anti-neuroinflammatory activity. According to the authors [3], this property is due to the capacity for reducing the levels of NO, IL-6, TNF-α and inducible nitric oxide synthase (iNOS), for inhibiting the expression of NF-κB and phosphorylation of IκBα (p-IκBα) ...

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Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant Nymphoides indica in Human Keratinocytes

Cited by 18 publications

References 45 publications

An Anthocyanin-Enriched Extract from Vaccinium uliginosum Improves Signs of Skin Aging in UVB-Induced Photodamage

An Anthocyanin-Enriched Extract from Vaccinium uliginosum Improves Signs of Skin Aging in UVB-Induced Photodamage

Ameliorative and Synergic Effects of Derma-H, a New Herbal Formula, on Allergic Contact Dermatitis

Editorial to Special Issue—Anti-Inflammatory Activity of Natural Products

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