Anti-inflammatory, anti-bacterial, and cytotoxic activity of fibrous clays

Cervini-Silva, Javiera; Nieto‐Camacho, Antonio; Ramírez‐Apán, María Teresa; Gómez‐Vidales, Virginia; Palacios, Eduardo; Montoya, J.A.; Jesús, Elba Ronquillo de

doi:10.1016/j.colsurfb.2015.03.019

Cited by 46 publications

(24 citation statements)

References 32 publications

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“…The present findings expanded on a report showing that structural Fe(III) in palygorskite [35] and, to a much lesser extent, sepiolite [36] served as oxidant towards hydrocortisone. A related study reported electrophoretic mobility values for sepiolite, palygorskite, and halloysite suspensions corresponding to −1.44 ± 0.155, −1.24 ± 0.114, and −4.055 ± 0.18 m cm V −1 s −1 [19], confirming an increased charge density for halloysite surfaces. In this light, we explained the higher extent of LP inhibition by CLA-1 vs sepiolite or palygorskite because of concentric dissolution, resulting in the continuous production of highly reactive sites (kinks, edges, sites), enabling silanol groups that stabilize electron deficient species (i.e., HO • ).…”

Section: Lipid Peroxidationmentioning

confidence: 73%

“…Emilia García-Romero (Departamento de Cristalografía y Mineralogía, Facultad de Ciencias Geológicas, Universidad Complutense, Madrid, Spain) and Mercedes Suárez (Departamento de Geología, Universidad de Salamanca, Salamanca, Spain); and Dr. John Keeling (Resource Evaluation and Planning Section, Geological Survey, Minerals and Energy Resources, Primary Industries and Resources, South Adelaide, Australia). It is worth a pause to note that a related study reported that these clays also show anti-inflammatory, antibacterial, and cytotoxic activity [19].…”

Section: Methodsmentioning

confidence: 98%

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Oxidative stress inhibition and oxidant activity by fibrous clays

Cervini-Silva

Nieto‐Camacho

Gómez‐Vidales

2015

Colloids and Surfaces B: Biointerfaces

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Section: Lipid Peroxidationmentioning

confidence: 73%

Section: Methodsmentioning

confidence: 98%

Oxidative stress inhibition and oxidant activity by fibrous clays

Cervini-Silva

Nieto‐Camacho

Gómez‐Vidales

2015

Colloids and Surfaces B: Biointerfaces

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“…Nonetheless, these differences could be ascribed to differences in the type of cell culture [ 110 ]. Apart from anti-inflammatory, antibacterial and anti-oxidant properties of a natural Spanish palygorskite, its cytotoxicity against murine macrophages has been reported to start from 300 µg/mL onwards [ 58 , 59 ]. Particularly, authors reported a reduction of 20% viability at the aforementioned concentration.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, both clays decreased the leucocyte infiltration shortly after exposure in vivo on mouse ear edema (12-O-tetradecanoylphorbol-13-acetate (TPA) as inflammatory agent). In particular, sepiolite and palygorskite caused decreases on the number of infiltrated cells per field [ 59 ]. Analogously, other clay minerals, as halloysite and montmorillonite, proved macrophage cytocompatibility and negligible secretion of TNFa, as proinflammatory cytokines [ 123 ].…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, palygorskite (“attapulgite”) has been used as scaffolding material when included in poly(lactic-co-glycolic acid) nanofibers, being crucial for mesenchymal cell adhesion and proliferation [ 57 ]. Sepiolite and palygorksite inhibit lipid peroxidation and possess anti-inflammatory properties by reducing neutrophil migration and edema [ 58 , 59 ]. Pharmaceutical grade palygorskite (Pharmasorb ® colloidal) did not only demonstrate to be biocompatible but also to protect fibroblasts from carvacrol cytotoxicity [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Wound Healing Activity of Nanoclay/Spring Water Hydrogels

et al. 2020

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Background: hydrogels prepared with natural inorganic excipients and spring waters are commonly used in medical hydrology. Design of these clay-based formulations continues to be a field scarcely addressed. Safety and wound healing properties of different fibrous nanoclay/spring water hydrogels were addressed. Methods: in vitro biocompatibility, by means of MTT assay, and wound healing properties were studied. Confocal Laser Scanning Microscopy was used to study the morphology of fibroblasts during the wound healing process. Results: all the ingredients demonstrated to be biocompatible towards fibroblasts. Particularly, the formulation of nanoclays as hydrogels improved biocompatibility with respect to powder samples at the same concentration. Spring waters and hydrogels were even able to promote in vitro fibroblasts motility and, therefore, accelerate wound healing with respect to the control. Conclusion: fibrous nanoclay/spring water hydrogels proved to be skin-biocompatible and to possess a high potential as wound healing formulations. Moreover, these results open new prospects for these ingredients to be used in new therapeutic or cosmetic formulations.

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Multifunctional Nanoclay‐Based Hemostatic Materials for Wound Healing: A Review

Tan,

Yang,

Zheng

et al. 2023

Adv Healthcare Materials

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Bleeding to death accounts for around 30–40% of all trauma‐related fatalities. Current hemostatic materials are mainly mono‐functional or have insufficient hemostatic capacity. Nanoclay has been recently shown to accelerate hemostasis, improve wound healing, and provide the resulting multifunctional hemostatic materials antibacterial, anti‐inflammatory, and healing‐promoting due to its distinctive morphological structure and physicochemical properties. Herein, the chemical design and action mechanism of nanoclay‐based hemostatic, antibacterial, and pro‐wound healing materials in the context of wound healing are discussed. The physiological processes of hemostasis and wound healing to elucidate the significance of nanoclay for functional wound hemostatic dressing design are outlined. A summary of the features of various nanoclay and product types used in wound hemostatic dressings is provided. Nanoclay can be antimicrobial due to the slow release of metal ions and has an abundant surface charge allowing for high affinity for proteins and cells, which can activate the coagulation reaction or facilitate tissue repair. Nanoclay with a microporous structure can be used as drug carriers to create composites critical for inhibiting bacterial growth on wounds or promoting the regeneration of vascular, muscle, and skin tissues. Directions for further research and innovation of nanoclay‐based multifunctional materials for hemostasis and tissue regeneration are explored.

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Anti-inflammatory, anti-bacterial, and cytotoxic activity of fibrous clays

Cited by 46 publications

References 32 publications

Oxidative stress inhibition and oxidant activity by fibrous clays

Oxidative stress inhibition and oxidant activity by fibrous clays

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

Multifunctional Nanoclay‐Based Hemostatic Materials for Wound Healing: A Review

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