Anti-inflammatory, anti-infectious and anti-cancer potential of marine algae and sponge: A review

Naqvi, Syed Ali Raza; Sherazi, Tauqir A.; Hassan, Sadaf ul; Shahzad, Sohail Anjum; Faheem, Zahra

doi:10.1177/20587392221075514

Cited by 6 publications

(6 citation statements)

References 122 publications

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“…[38][39][40] Plant-derived polysaccharides and their derivatives are among the most widely examined natural bioactive materials, due to their good safety, broad availability, and multiple bioactivities (including anti-inflammatory, antioxidant, and anti-apoptotic effects). [41][42][43][44][45] Nevertheless, these natural antiinflammatory agents generally show relatively low intrinsic efficacy, mainly due to their limited absorption and low bioavailability. Consequently, polysaccharide derivatives of diverse structures have been synthesized to afford bioactive materials with potent anti-inflammatory effects, such as glycopolymers, glycoproteins, glycosaminoglycan, and polyethyleneimineconjugated polysaccharides, [46][47][48][49] which can inhibit proinflammatory cytokine production as well as inhibit activation of macrophages and neutrophils.…”

Section: Different Anti-inflammatory Nanotherapies Based On Bioactive...mentioning

confidence: 99%

Anti‐Inflammatory Nanotherapies Based on Bioactive Cyclodextrin Materials

Li,

Chen,

et al. 2023

Advanced NanoBiomed Research

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Despite remarkable advances in understanding the mechanisms underlying inflammation, the currently available anti‐inflammatory therapies have many limitations, such as poor efficacies, low selectivity, and severe adverse effects. Bioactive materials with intrinsically anti‐inflammatory activities have emerged as promising drug candidates for the treatment of inflammatory disorders. Among them, nanotherapies based on bioactive cyclodextrin (CD) materials have attracted much attention, owing to their multiple advantages, including broad availability, well‐controlled structures, easy functionalization, good processibility, high cost‐effectiveness, and excellent biocompatibility. This review provides a comprehensive overview of the recent advancements in the development and applications of anti‐inflammatory nanoparticles (NPs) based on bioactive CD materials, with special focus on reactive oxygen species‐scavenging NPs and NPs capable of regulating inflammatory cell recruitment and activation. In addition, the applications of these anti‐inflammatory nanotherapies in the treatment of different acute/chronic inflammatory diseases are highlighted. Furthermore, major challenges in the clinical translation of these new generation anti‐inflammatory therapies derived from bioactive CD materials are discussed.

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Section: Different Anti-inflammatory Nanotherapies Based On Bioactive...mentioning

confidence: 99%

Anti‐Inflammatory Nanotherapies Based on Bioactive Cyclodextrin Materials

Li,

Chen,

et al. 2023

Advanced NanoBiomed Research

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“…have shown inhibitory effects against some bacteria. The antimicrobial activity is associated with the presence of compounds like diterpenes and sterols [90].…”

Section: Antimicrobial and Antiviral Activitymentioning

confidence: 99%

Harnessing the power of seaweed: unveiling the potential of marine algae in drug discovery

Pereira,

Valado

2023

Explor Drug Sci

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Seaweeds, also known as marine algae, have gained attention as a promising source of bioactive compounds with potential applications in drug discovery. This review explores the emerging field of seaweed-based drug discovery and highlights the diverse range of bioactive compounds found in seaweeds, including polysaccharides, phlorotannins, pigments, and peptides. These compounds exhibit various pharmacological activities such as antioxidant, anti-inflammatory, antimicrobial, antiviral, and anticancer effects. Seaweeds have demonstrated particular promise in the areas of cancer research, with certain species showing potent antitumor properties. Additionally, their anti-inflammatory, antimicrobial, and neuroprotective potential has captured scientific interest in the treatment of chronic diseases and neurodegenerative disorders. However, challenges related to compound identification, extraction methods, scalability of seaweed cultivation, and understanding the mechanisms of action still need to be addressed. As researchers employ advanced technologies and dive deeper into the chemical composition of seaweeds, the untapped potential of these marine organisms in drug discovery awaits further exploration and holds significant promise for future therapeutic advancements.

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“…The conventional chemotherapy drug cytarabine is derived from a natural product found in a marine sponge. 5 In addition, numerous other natural products have exhibited antitumor properties, including callyaerins, gallic acid, and shikonin. [5][6][7][8] Recently, TPA (12-O-tetradecanoylphorbol-13-acetate, see Figure 1) has garnered attention from researchers as a promising anti-leukemia drug.…”

Section: Introductionmentioning

confidence: 99%

“…5 In addition, numerous other natural products have exhibited antitumor properties, including callyaerins, gallic acid, and shikonin. [5][6][7][8] Recently, TPA (12-O-tetradecanoylphorbol-13-acetate, see Figure 1) has garnered attention from researchers as a promising anti-leukemia drug. TPA is a phorbol ester which was first isolated from the seed oil of croton tree, and it has shown tumor-promoting properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and anti-leukemia activity of phorbol 13,20-diesters and phorbol 12,13,20-triesters

Wang

Feng

et al. 2023

Journal of Chemical Research

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Phorbol esters and their derivatives, such as TPA, have been reported as potential natural antitumor products, with some derivatives entering clinical research for leukemia treatment. In this study, 16 phorbol derivatives were synthesized from phorbol, and their anti-leukemia activity against Jurkat, HL-60, and K562 were tested. The results showed that several derivatives had anti-leukemia activity, with 5B demonstrating the strongest cytotoxic activity against the K562 cell line (IC50 = 0.24 ± 0.04 μM). Based on the IC50 values, a structure-activity relationship was established. When the substituent contained an aromatic group, phorbol derivatives esterified with long-chain organic acids at three reactive hydroxyl groups (C12-OH, C13-OH, and C20-OH) had better activity. When aryl groups were absent from the substituent groups, phorbol derivatives esterified with short-chain organic acids at two hydroxyl groups had better activity. Derivatives esterified with heterocyclic acids, either tri-substituted or di-substituted, showed a significant decrease in cytotoxicity. The mechanism of anti-leukemia activity was explored through flow cytometry, which indicated that phorbol esters inhibited the growth of leukemia cells by inducing apoptosis, leading to cell death. Molecular docking data of compound 5B docking to PKC δC1B suggested that substituent groups should not be too large, and caution should be taken when substituting C20-OH. Overall, these findings provide valuable insights into the design of more effective phorbol esters as anti-leukemia agents, but further research is needed to confirm their safety and efficacy in clinical settings.

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Anti-inflammatory, anti-infectious and anti-cancer potential of marine algae and sponge: A review

Cited by 6 publications

References 122 publications

Anti‐Inflammatory Nanotherapies Based on Bioactive Cyclodextrin Materials

Anti‐Inflammatory Nanotherapies Based on Bioactive Cyclodextrin Materials

Harnessing the power of seaweed: unveiling the potential of marine algae in drug discovery

Synthesis and anti-leukemia activity of phorbol 13,20-diesters and phorbol 12,13,20-triesters

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