Anti-inflammatory, Anti-ulcer, Antipyretic, Analgesic and Cns Stimulant Activities of Marine Bryozoan Zoobotryon verticillatum

Sankar, R.; Murugan, A.; Sivakumar, V.

doi:10.5567/pharmacologia.2013.15.21

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…The aqueous extract of P. boergesenii reduced gluconeogenesis by the activity of gluconeogenic enzymes such as fructose -1, 6-diphosphatase and flucose-6-phosphatase, and raised the activities of the key glycolytic enzymes such as phosphoglucoisomerase, hexokinase, and aldolase in liver. Pharmacological properties of bryozoan extract by using standard methods on albino rats, and they found that the bryozoan extract had antipyretic, analgesic, anti-inflammatory, dose dependent and Central Nervous System (CNS) stimulant activity 43 . The antimicrobial properties against human pathogenic bacteria and fungus of crude extracts of Gracilariacorticate 44 .The results were explained the seaweed extracts having traditional claims of effectiveness and could serve as useful source of new antimicrobial agents.…”

Section: Seaweed Use As a Medicinal Sourcementioning

confidence: 99%

Seaweed Composition and Potential Uses

Keyimu¹,

Abuduli²

2019

IJCTR

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This article presents information on the chemical components of seaweeds, proteins, amino acids, minerals, lipids, vitamins, dietary fiber, antioxidant, anti-bacterial and anti-fungal compounds are reviewed in relation to potential food and medicinal uses. The nutritive values of seaweeds are briefly discussed for uses as a food. Bioactive compounds found in seaweeds are also discussed for pharmaceutical uses.

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Section: Seaweed Use As a Medicinal Sourcementioning

confidence: 99%

Seaweed Composition and Potential Uses

Keyimu¹,

Abuduli²

2019

IJCTR

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“…Over the past decade, considerable attention has been centered on researches related to marine macroalgae as they are the largest reservoir of structurally diverse, bioactive compounds and secondary metabolites (3)(4)(5)(6). Though the anti-inflammatory, anticoagulant, antimicrobial, anticancer, antiviral, antioxidant, hypoglycaemic, antiulcer, neuroprotective, and hepatoprotective properties of seaweeds are well documented, the phytochemicals attributed to these properties are yet to be explored (7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and anti-inflammatory activities of methanol and aqueous extracts of Sargassum wightii

Rout

Rath

Bhattamisra

et al. 2021

J Herbmed Pharmacol

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Introduction: Antioxidants of natural sources for the treatment of many ailments have taken priority since the last decades. Recently, researches have been focused on marine algae as they are the largest reservoir of bioactive compounds. Hence, the objective of this study was to explore the in-vitro antioxidant and anti-inflammatory activities of methanolic and aqueous extracts of Sargassum wightii. Methods: The total phenolics, flavonoids, and ascorbic acid (AA) contents were evaluated informs of gallic acid equivalent (GAE), rutin equivalent (RUE), and AA equivalent, respectively. The aqueous and methanolic extracts were isolated. The antioxidant activities were explored using2,2-diphenyl-1-picrylhydrazil (DPPH), superoxide dismutase (SOD), hydroxyl radical scavenging, and ferric reducing power assays. The in vitro anti-inflammatory activity was assayed using nitric oxide radical scavenging, inhibition of protein denaturation, and antiproteinase activities. Results: We observed significant changes in DPPH scavenging activity with both methanolicSargassum extract (MSE) and aqueous Sargassum extract (ASE) [IC50: 511.15 µg/mL and 927.05µg/mL, respectively]. Methanolic extract showed a greater SOD scavenging activity [IC50: 369.56µg/mL] and hydroxyl radical scavenging potential [IC50: 668.93 µg/mL] than that of ASE [SOD,IC50: 923.94 µg/mL; hydroxyl ion, IC50: 953.57 µg/mL]. In the Ferric reducing antioxidant power assay, MSE and ASE exhibited absorbance of 0.93±0.12 and 0.59±0.08, respectively, at 1200 µg/mL each. Both methanol and ASEs showed NO– scavenging activity having IC50 in order, AA(96.46 µg/mL) <MSE (963.50 µg/mL) <ASE (1974.88 µg/mL). However, the protein denaturation inhibition and antiproteinase activity of both these extracts at 1000 µg/mL were similar. Conclusion: Sargassum wightii has promising antioxidant and anti-inflammatory activities and could be a potential candidate for drug development targeting oxidative stress-mediated inflammatory diseases.

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“…Marine biodiversity has provided around three thousand new chemicals, the most predominant of which are associated with polyketides, peptides, terpenoids, phenolics, polysaccharides and alkaloids [ 4 ]. Various bioactivity functions such as anticancer [ 5 – 7 ], phytotoxicity [ 8 – 11 ], antioxidant [ 12 – 16 ], antimicrobial [ 17 – 19 ], analgesic [ 20 – 21 ], hypotensive [ 22 ], hypoglycemic [ 23 ], antiprotozoal [ 24 ] and plant protecting [ 25 – 26 ] effects, have been exhibited by these marine-derived metabolites. Additionally, some of them also inhibited many enzymes including Na + /K + -ATPase [ 26 ], tyrosine kinase [ 27 ], phosphatidylinositol-specific phospholipase C [ 28 ], topoisomerase II [ 29 ], cathepsin L [ 30 ], protein tyrosine phosphatase B (PtpB) [ 31 ] and serine protease [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Pyridinoacridine alkaloids of marine origin: NMR and MS spectral data, synthesis, biosynthesis and biological activity

Sandjo¹,

Kuete²,

Biavatti³

2015

Beilstein J. Org. Chem.

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SummaryThis review focuses on pyridoacridine-related metabolites as one biologically interesting group of alkaloids identified from marine sources. They are produced by marine sponges, ascidians and tunicates, and they are structurally comprised of four to eight fused rings including heterocycles. Acridine, acridone, dihydroacridine, and quinolone cores are features regularly found in these alkaloid skeletons. The lack of hydrogen atoms next to quaternary carbon atoms for two or three rings makes the chemical shift assignment a difficult task. In this regard, one of the aims of this review is the compilation of previously reported, pyridoacridine 13C NMR data. Observations have been made on the delocalization of electrons and the presence of some functional groups that lead to changes in the chemical shift of some carbon resonances. The lack of mass spectra information for these alkaloids due to the compactness of their structures is further discussed. Moreover, the biosynthetic pathways of some of these metabolites have been shown since they could inspire biomimetic synthesis. The synthesis routes used to prepare members of these marine alkaloids (as well as their analogues), which are synthesized for biological purposes are also discussed. Pyridoacridines were found to have a large spectrum of bioactivity and this review highlights and compares the pharmacophores that are responsible for the observed bioactivity.

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Anti-inflammatory, Anti-ulcer, Antipyretic, Analgesic and Cns Stimulant Activities of Marine Bryozoan Zoobotryon verticillatum

Cited by 4 publications

References 12 publications

Seaweed Composition and Potential Uses

Seaweed Composition and Potential Uses

Antioxidant and anti-inflammatory activities of methanol and aqueous extracts of Sargassum wightii

Pyridinoacridine alkaloids of marine origin: NMR and MS spectral data, synthesis, biosynthesis and biological activity

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