Anti-Inflammatory, Barrier Maintenance, and Gut Microbiome Modulation Effects of Saccharomyces cerevisiae QHNLD8L1 on DSS-Induced Ulcerative Colitis in Mice

Abstract

The use of probiotics has been considered as a new therapy option for ulcerative colitis (UC), and yeast has recently received widespread recommendation for human health. In this study, the probiotic characteristics of four yeast strains, Saccharomyces boulardii CNCMI-745, Kluyveromyces marxianus QHBYC4L2, Saccharomyces cerevisiae QHNLD8L1, and Debaryomyces hansenii QSCLS6L3, were evaluated in vitro; their ability to ameliorate dextran sulfate sodium (DSS)-induced colitis was investigated. Among these, S. cerevisiae QHNLD8L1 protected against colitis, which was reflected by increased body weight, colon length, histological injury relief, decreased gut inflammation markers, and intestinal barrier restoration. The abundance of the pathogenic bacteria Escherichia–Shigella and Enterococcaceae in mice with colitis decreased after S. cerevisiae QHNLD8L1 treatment. Moreover, S. cerevisiae QHNLD8L1 enriched beneficial bacteria Lactobacillus, Faecalibaculum, and Butyricimonas, enhanced carbon metabolism and fatty acid biosynthesis function, and increased short chain fatty acid (SCFAs) production. Taken together, our results indicate the great potential of S. cerevisiae QHNLD8L1 supplementation for the prevention and alleviation of UC.

Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function

“…YE treatment recovered the pathological and abnormal morphological changes of colon tissues, reduced the levels of LPS and D-LA in serum, and up-regulated ZO-1 and Occludin. Our finding was in accordance with recent research that showed saccharomyces cerevisiae QHNLD8L1 alleviated the dextran sulfate sodium-induced colitis in mice by modulating specific microbiota, increasing SCFA production, and enhancing the gut barrier [80] .…”

Maternal Synbiotic Supplementation with B. breve M-16V and scGOS/lcFOS Shape Offspring Immune Development and Gut Microbiota at the End of Suckling

“…are novel species of potential beneficial microorganism productors of SCFAs. Additionally, Facecalibaculum contributes to reducing colon inflammation by stimulating Treg cells [ 62 ]. These results suggest that synbiotic maternal supplementation during gestation and lactation boosts the colonization of the offspring gut during suckling.…”

Huangqin Tea Total Flavonoids–Gut Microbiota Interactions: Based on Metabolome and Microbiome Analysis

“…As a potential probiotic bacterium, its species has potential therapeutic effects in metabolic, inflammatory, and neoplastic diseases [28][29][30][31]. The upregulation of Butyricimonas abundance can enhance the function of fatty acid biosynthesis, increase the production of SCFAs, and promote the synthesis of butyrate [32]. Recent studies have found that Phocaeicola strains can help maintain the epithelial barrier by regulating cytokine levels and the secretion of SCFAs, thereby improving dextran sodium sulfate-induced colitis in mice [33].…”