Anti-inflammatory Constituents of Mortonia greggii Gray

Arciniegas, Amira; Apan, Ma. Teresa Ramírez; Pérez-Castorena, Ana L.; Vivar, Alfonso Romo de

doi:10.1515/znc-2004-3-421

Cited by 23 publications

(9 citation statements)

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“…20 and 21) 5.3.2.1. Antiinflammatory and autoimmune conditions: 3-Oxo-friedelan-28-oic acid (70) showed moderate (32%) inhibition of edema in the carrageenan-induced rat paw edema test and good inhibition of TPA-induced rat ear edema (Arciniegas et al, 2004). Polpunonic acid (=polpunoic acid, maytenoic acid, maytenonic acid) (69) inhibited IL-2 release, and wilforic acid B (72) inhibited production of IL-2, IL-8, and TNF-α (Duan et al, 2000).…”

Section: Insecticidal Activitymentioning

confidence: 99%

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

et al. 2007

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Plants in the genus Tripterygium, such as Tripterygium wilfordii Hook. f., have a long history of use in traditional Chinese medicine. In recent years there has been considerable interest in the use of Tripterygium extracts and of the main bioactive constituent, the diterpene triepoxide triptolide (1), to treat a variety of autoimmune and inflammation-related conditions. The main mode of action of the Tripterygium extracts and triptolide (1) is the inhibition of expression of proinflammatory genes such as those for interleukin-2 (IL-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2) and interferon-gamma (IFN-γ). The efficacy and safety of certain types of Tripterygium extracts were confirmed in human clinical trials in the US and abroad. Over 300 compounds have been identified in the genus Tripterygium, and many of these have been evaluated for biological activity. The overall activity of the extract is based on the interaction between its components. Therefore, the safety and efficacy of the extract cannot be fully mimicked by any individual constituent. This review discusses the biochemical composition and biological and pharmacological activities of Tripterygium extracts, and their main bioactive components.

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Section: Insecticidal Activitymentioning

confidence: 99%

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

et al. 2007

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“…The root of Mortonia greggii furnished compounds 62 and 257, which showed moderate inhibition of TPA-induced ear edema and modest effects in anti-inflammatory tests. 106 Compound 257 is an NO inhibitor. 106…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…costaricensis[122], Au. populnea[170],Mortonia greggii[106] Group 5p: 4a-hydroxy-14-deoxy-9-epi-alatol type 1b-Acetoxy-2b,8b,9a-tribenzoyloxy-4a,6a-dihydroxydihydro-bagarofuran (258) C. rosthornianus [171] 1b-Acetoxy-8b,9a-dibenzoyloxy-2bfuroyloxy-4a,6a-dihydroxydihydro-bagarofuran (259) C. rosthornianus [171] 1b-Acetoxy-8b,9a-dibenzoyloxy-4a,6adihydroxy-2b-(amethylbutanoyloxy)dihydro-bagarofuran (260) C. rosthornianus [172], C. hindsii [125]a Known.…”

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confidence: 99%

The dihydro-β-agarofuran sesquiterpenoids

Gao¹,

Wu²,

Zhang³

et al. 2007

Nat. Prod. Rep.

171

136

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Dihydro-Beta-agarofuran sesquiterpenoids are a structurally diverse class of natural products based on tricyclic 5,11-epoxy-5Beta,10alpha-eudesman-4-(14)-ene skeleton. Between January 1990 and June 2006, 462 new dihydro-Beta-agarofuran sesquiterpenoids of 74 structural types have been isolated from about 64 species of Celastraceae, 3 species of Hippocrateaceae and one species of Lamiaceae. The present review covers the chemical and biological activity research of dihydro-Beta-agarofuran sesquiterpenoids in the past 16 years. The chemical research includes structural classification into sesquiterpene polyesters and macrolide sesquiterpene pyridine alkaloids, synthesis of dihydro-Beta-agarofuran as well as extraction, isolation and purification methods. The biological activity research includes activities such as multidrug resistance (MDR) reversal activity, HIV inhibition, cytotoxicity, antitumor activity, antifeedant activity and insecticidal activity with some insights to their modes of actions.

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“…The following are available online, Table S1: Pentacyclic triterpenoids isolated from Celastraceae species (2001–2021) [ 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , 278 , 279 , 280 , 281 , 282 , 283 , 284 , 285 , 286 , 287 , 288 , 289 , 290 , 291 , 292 , 293 , 294 , 295 , 296 , 297 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 305 , 306 , 307 ,…”

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Pentacyclic Triterpenoids Isolated from Celastraceae: A Focus in the 13C-NMR Data

et al. 2022

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The Celastraceae family comprises about 96 genera and more than 1.350 species, occurring mainly in tropical and subtropical regions of the world. The species of this family stand out as important plant sources of triterpenes, both in terms of abundance and structural diversity. Triterpenoids found in Celastraceae species display mainly lupane, ursane, oleanane, and friedelane skeletons, exhibiting a wide range of biological activities such as antiviral, antimicrobial, analgesic, anti-inflammatory, and cytotoxic against various tumor cell lines. This review aimed to document all triterpenes isolated from different botanical parts of species of the Celastraceae family covering 2001 to 2021. Furthermore, a compilation of their 13C-NMR data was carried out to help characterize compounds in future investigations. A total of 504 pentacyclic triterpenes were compiled and distinguished as 29 aromatic, 50 dimers, 103 friedelanes, 89 lupanes, 102 oleananes, 22 quinonemethides, 88 ursanes and 21 classified as others.

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Anti-inflammatory Constituents of Mortonia greggii Gray

Cited by 23 publications

References 1 publication

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

The dihydro-β-agarofuran sesquiterpenoids

Pentacyclic Triterpenoids Isolated from Celastraceae: A Focus in the 13C-NMR Data

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