Anti-inflammatory cytokine profile in acute coronary syndromes: behavior of interleukin-10 in association with serum metalloproteinases and proinflammatory cytokines

Tziakas, Dimitrios; Chalikias, Georgios K.; Hatzinikolaou, H.; Parissis, John; Papadopoulos, Elias D.; Trypsianis, Grigorios; Papadopoulou, Evropi; Tentes, Ioannis; Karas, S.; Hatseras, D.I.

doi:10.1016/s0167-5273(03)00084-6

Cited by 36 publications

(36 citation statements)

References 42 publications

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“…Some contrasting observations regard a different production of IL10 in AMI and UA. In particular, AMI patients have been found to exhibit higher IL10 levels in comparison with UA patients; this finding could be a consequence of the intensity and duration of the inflammatory process but also of a different pattern of immunological reactions that underlie AMI and UA [30]. Our experiments exploring the IL10 production by cultured lymphomonocytes evaluated a functional aspect of these cells and permit us to confirm a reduced production in both conditions of ACS but no substantial differences between AMI and UA.…”

Section: Discussionmentioning

confidence: 61%

“…In recent years more attention has been given to the role of IL10 in the pathogenesis of atherosclerosis and in the ACS [12][13][14][15][28][29][30]. IL10 is a potent antiinflammatory cytokine, secreted by lymphocytes of the Th2 subtype and also in large amounts by macrophages.…”

Section: Discussionmentioning

confidence: 99%

“…A series of in vitro and in vivo studies in animals showed that the overexpression of IL10 and IL4 was followed by smaller and more stable atherosclerotic lesions [36]; on the contrary, IL10-deficient mice showed an enhanced inflammatory response following experimental AMI, demonstrated by increased neutrophil recruitment, elevated plasma levels of TNFα and high tissue expression of ICAM-1 [37]. In vitro experiments demonstrated that IL10 inhibits the stimulatory effect of oxidised lipids on human aortic endothelial cells [38]; clinical data reported a decrease of circulating levels of IL10 in patients with ACS and a correlation with the severity of clinical status of patient [29,30]. These observations suggested that IL10 may be an important stabilising factor of vulnerable atherosclerotic plaque and have a protective role in myocardial damage induced by ischaemia through the suppression of acute inflammatory process.…”

Section: Discussionmentioning

confidence: 99%

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Pro-inflammatory/anti-inflammatory cytokine imbalance in acute coronary syndromes

et al. 2006

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The aim of this study was to evaluate the presence of an imbalance between proinflammatory and anti-inflammatory mediators in patients affected by acute coronary syndromes (ACS). We considered two groups of 26 and 28 patients with acute myocardial infarction (AMI) and unstable angina (UA) respectively, compared with a group of 30 patients with stable angina and 30 healthy volunteers. We evaluated the production in cultured and stimulated lymphomonocytes of interferon (IFN)gamma and tumour necrosis factor (TNF)alpha, which are well known to possess proinflammatory effects, and of interleukin (IL)10, which has been shown to have a protective anti-inflammatory activity. We also assessed the clinical characteristics of groups and, particularly, we evaluated the circulating levels of C-reactive protein (hs-CRP). We found a significant increase of IFNgamma and TNFalpha production (P<0.01) and a significant decrease of IL10 production (P<0.05) in cultures of lymphomonocytes taken from patients with AMI and UA compared with SA patients and controls. No significant changes where found between AMI and UA patients and SA patients and controls. Circulating levels of hs-CRP were significantly increased (P<0.01) in patients with ACS compared with the other control groups. Our data showed an increased production of proinflammatory mediators in ACS that may be detectable both in circulating blood and in cell cultures where it is possible to evaluate in a better way the functional state of cells; this finding was associated with a reduced production of the antiinflammatory cytokine IL10. In conclusion, a relevant imbalance is present in ACS and this fact could contribute to plaque instability and clinical manifestations.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pro-inflammatory/anti-inflammatory cytokine imbalance in acute coronary syndromes

et al. 2006

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“…Conversely and perhaps more importantly, we found exceptionally high concentrations of IL-10: the median concentration of 7.56 pg/mL is more than two times higher than the average baseline value from other studies of healthy adults. This antiinflammatory cytokine suppresses IL-6 production as well as other proinflammatory pathways (77), and lower concentrations of IL-10 have been associated with increased risk for chronic diseases (4,78). This pattern of results provides additional evidence for meaningful variation in key aspects of inflammation across populations, and it suggests that the balance of pro-to antiinflammatory signaling may differ in the Philippines, perhaps explaining the exceptionally low concentrations of CRP (50,57).…”

Section: Vaccine Responsiveness In Adolescence Predicts Crp In Youngmentioning

confidence: 89%

Early environments and the ecology of inflammation

McDade

2012

Proc. Natl. Acad. Sci. U.S.A.

185

154

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Recent research has implicated inflammatory processes in the pathophysiology of a wide range of chronic degenerative diseases, although inflammation has long been recognized as a critical line of defense against infectious disease. However, current scientific understandings of the links between chronic low-grade inflammation and diseases of aging are based primarily on research in high-income nations with low levels of infectious disease and high levels of overweight/obesity. From a comparative and historical point of view, this epidemiological situation is relatively unique, and it may not capture the full range of ecological variation necessary to understand the processes that shape the development of inflammatory phenotypes. The human immune system is characterized by substantial developmental plasticity, and a comparative, developmental, ecological framework is proposed to cast light on the complex associations among early environments, regulation of inflammation, and disease. Recent studies in the Philippines and lowland Ecuador reveal low levels of chronic inflammation, despite higher burdens of infectious disease, and point to nutritional and microbial exposures in infancy as important determinants of inflammation in adulthood. By shaping the regulation of inflammation, early environments moderate responses to inflammatory stimuli later in life, with implications for the association between inflammation and chronic diseases. Attention to the eco-logics of inflammation may point to promising directions for future research, enriching our understanding of this important physiological system and informing approaches to the prevention and treatment of disease.

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“…Indeed, acute MI is associated with high production of proinflammatory cytokines (TNF-, IL-1, IL-6 and IL-8) by monocytes, and inflammatory mononuclear cells infiltrate the border zone, cardiomyocytes and endothelial cells ). This represents parts of an intrinsic myocardial stress response system to tissue injury that may contribute not only to wound healing but also to secondary injury (Marx et al 1997;Gwechenberger et al 1999;Irwin et al 1999;Kato et al 1999;Pudil et al 1999;Deten and Zimmer 2002;Hillis et al 2003;Tziakas et al 2003).…”

Section: Myocardial Infarction and Pro-inflammatory Processesmentioning

confidence: 99%