2019
DOI: 10.3390/molecules24234375
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Anti-Inflammatory Derivatives with Dual Mechanism of Action from the Metabolomic Screening of Poincianella pluviosa

Abstract: Metabolomics approaches have become fundamental strategies for the analysis of complex mixtures, guiding the isolation of target compounds by focusing on unpublished or promising pharmacological properties. The discovery of novel anti-inflammatory agents is important due to several limitations regarding their potency, efficacy, and adverse effects. Thus, novel anti-inflammatory candidates are essential, aiming to find agents with better mechanisms of action. In this context, extracts from Poincianella pluviosa… Show more

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Cited by 18 publications
(9 citation statements)
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“…Results showed (Table 2 and Figure 4) that four out of five active species in the ex vivo human blood anti‐inflammatory assay presented remarkable inhibition for ear edema in mice: Acacia polyphylla ( 1 ), Poincianella pluviosa ( 13 ), Enterolobium contortisiliquum ( 18 ), and Holocalyx balansae ( 20 ). Croton‐oil induced ear edema inhibition for an ethanolic extract of Poincianella pluviosa has already been reported in the literature 32 with 70.9%. Therefore, the in vivo anti‐inflammatory activity was not assessed in our work or included in a comparative statistical analyses with one‐way ANOVA (Figure 4).…”
Section: Resultsmentioning
confidence: 87%
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“…Results showed (Table 2 and Figure 4) that four out of five active species in the ex vivo human blood anti‐inflammatory assay presented remarkable inhibition for ear edema in mice: Acacia polyphylla ( 1 ), Poincianella pluviosa ( 13 ), Enterolobium contortisiliquum ( 18 ), and Holocalyx balansae ( 20 ). Croton‐oil induced ear edema inhibition for an ethanolic extract of Poincianella pluviosa has already been reported in the literature 32 with 70.9%. Therefore, the in vivo anti‐inflammatory activity was not assessed in our work or included in a comparative statistical analyses with one‐way ANOVA (Figure 4).…”
Section: Resultsmentioning
confidence: 87%
“…Anti‐inflammatory activity in both ex vivo and in vivo assays with these four Fabaceae species in our study emphasise their great and promising pharmacological potential. Poincianella pluviosa has been reported for ear edema inhibition as well as cell recruitment 32 . A proteinase inhibitor from seeds of Enterolobium contortisiliquum presented a significant reduction of the number of molecules, enzymes, and cells involved in the inflammation such as nitric oxide synthase (NOS) enzymes (iNOS and eNOS‐positive) 33 .…”
Section: Resultsmentioning
confidence: 99%
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“…G. P. Lewis], popularly known as “sibipiruna” or “falso pau brasil,” is a domesticated plant in Brazil found mainly in the Atlantic forest and Pantanal biomes; it is widely used in ornamentation and is known for its high wood potential ( Carvalho, 2014 ). Few studies on the pharmacological activities of P. pluviosa are described in the literature, and the following activities have been specifically attributed to stem bark extract of P. pluviosa , including antimalarial ( Deharo et al, 2001 ; Kayano et al, 2011 ), anti-staphylococcal ( Guidi et al, 2020 ), wound healing in vitro and in vivo ( Bueno et al, 2016 ; Guidi et al, 2020 ), and anti-inflammatory ( Domingos et al, 2019 ).…”
Section: Introductionmentioning
confidence: 99%
“…Mattos, Swietenia macrophylla King, Schinus terebinthifoliusRaddi, Cariniana estrellensis (Raddi) Kuntze, Poincianellapluviosa (DC.) LP Queiros and Hymenaea courbaril L.) are widely distributed in Brazil and have great relevance in several segments, such as: in the recovering of degraded ecosystems, in the enrichment of forests, in urban landscaping, in the biomonitoring and phytoremediation of areas with heavy metals and in the production of food, cosmetics and pharmaceutical products (Silva et al 2010, Veggi et al 2014, Oliveira et al 2018, Balestrin et al 2019, Costa et al 2019, Domingos et al 2019, Souza et al 2019, Farias et al 2020, Lisboa et al 2020.…”
Section: Introductionmentioning
confidence: 99%