Anti-inflammatory Drugs in Equine Neonatal Medicine. Part II: Corticosteroids

Castagnetti, Carolina; Mariella, Jole

doi:10.1016/j.jevs.2015.02.012

Cited by 4 publications

(1 citation statement)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ability of anti-inflammatory drugs to reduce inflammation, caused by a variety of stimuli in equines has been widely reported (30,31). Non-steroidal anti-inflammatory drugs (NSAIDs), including ketoprofen, flunixin meglumine, firocoxib, and phenylbutazone, are commonly prescribed to treat inflammation in horses and have been shown to be very safe (12,32). These drugs have been evaluated in numerous studies and have been shown to reduce the pathology observed in horses infected with other microbial pathogens including equine protozoal myeloencephalitis (EPM) (33).…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory compounds reduce equine herpesvirus type 1 replication and cell-to-cell spread

Black

Frampton

2023

Front. Vet. Sci.

View full text Add to dashboard Cite

Equine herpesvirus type 1 (EHV-1) is a highly transmissible pathogen that leads to a variety of clinical disease outcomes in infected horses. A major sequela that can occur after an EHV-1 infection is a neurological disease termed equine herpesvirus myeloencephalopathy (EHM). Clinical manifestations of EHM include fever, ataxia, incontinence, and partial to full paralysis, which may ultimately lead to the euthanization of the infected horse. To develop an effective treatment strategy for EHM, it is critical that the specific virus–host interactions that lead to EHM be investigated so that safe and effective therapeutic interventions can be developed and delivered. In this study, we examined the ability of four non-steroidal anti-inflammatory drugs (NSAIDs), a steroidal anti-inflammatory drug (dexamethasone), a Rho-kinase (ROCK) inhibitor, and a JAK/STAT inhibitor (AG490) to reduce EHV-1 virus yields and cell-to-cell spread. We show that the NSAID, flunixin meglumine (FM), and the JAK/STAT inhibitor, AG490, significantly reduced virus yields in endothelial and epithelial cell lines, and this inhibition was similar for two neurologic and two non-neurologic EHV-1 strains. In addition to reducing virus yields, AG490 and FM also significantly reduced the ability of EHV-1 to spread laterally from cell to cell.

show abstract

Section: Discussionmentioning

confidence: 99%