Anti-inflammatory effect and mechanism of action of Lindera erythrocarpa essential oil in lipopolysaccharide-stimulated RAW264.7 cells

Nerolidol inhibited U-251 human glioblastoma cell proliferation and triggered apoptosis via the upregulation of the p38 MAPK signaling pathway

“…33 As such, the underlying anticancer mechanisms of NRD are thought to involve cell cycle arrest, 27 oxidative phosphorylation reduction 32 and apoptosis. 34 In the current research, NRD treatment reduced the mRNA expression of cyclin-D1, CDK4 and CDK6, while it increased p21 expression and reduced CDK1 and cyclin-B1 protein levels. The cell-cycle transition from the S phase to the G2/M phase is largely determined by the CDK1 and cyclin-B1 complexes.…”

Review of Phytochemicals Present in Psidium guajava Plant and Its Mechanism of Action on Medicinal Activities

“…Oleanolic acid (OA): Oleanolic acid is a triterpene with antioxidant and anti-inflammatory properties. It may play a role in protecting the liver and may have potential benefits for skin health [ 12 ]. Quercetin: Quercetin is a flavonoid known for its antioxidant and anti-inflammatory effects.…”

“…Beta-sitosterol: Beta-sitosterol is a plant sterol that may help lower cholesterol levels and support prostate health [ 4 ]. Uvaol, oleanolic, and ursolic acids: These are triterpenes with various potential health benefits, including anti-inflammatory and antioxidant properties [ 12 ]. It's important to note that while these compounds have been studied for their potential health benefits, consuming guava as part of a balanced diet can contribute to overall health and well-being.…”

Combination of Taurine and Black Pepper Extract as a Treatment for Cardiovascular and Coronary Artery Diseases

“…Hypertension, atherosclerosis and CAD are characterized as chronic inflammatory diseases and are clinically associated with increased expression of important pro-inflammatory receptors (e.g., toll-like receptors (TLR) and receptor for advanced glycation end-products (RAGE)) and molecules (e.g., high-mobility group box-1 (HMGB-1), interleukin (IL)-1β, IL-6, tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), nitric oxide (NO), prostaglandin E 2 (PGE 2 ), inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2) [8,37]. Thus, their downregulation and inhibition have been reported in the literature as potential therapeutic targets for CVDs [38]. Taurine and terpenes contain general anti-inflammatory effects (Table 1), which may be useful in combination therapy as due to their abilities to suppress the expression of pro-inflammatory cytokines and alleviate cell and tissue damage in multiple disease states [39][40][41][42].…”

“…Additionally, α-pinene has also been shown to attenuate MAPK and NF-κB activation, resulting in the decreased expression of pro-inflammatory factors IL-6, TNF-α, NO, iNOS, and COX-2 [44]. The terpenes BCP, α-humulene, and α-pinene have been shown to inhibit the expression of NO synthase and COX-2 through inhibition of MAPK action through IKK-B inhibition [38], while limonene was shown to mitigate pro-inflammatory cytokines secretion as well as rescue iNOS, MMP-1, and MMP-3 gene transcription through inhibition of MAPK/JNK-dependent NF-κB activation pathways [62]. Pre-treatment with limonene (25, 50 and 75 mg/kg) inhibited release of pro-inflammatory cytokines (i.e., TNF-α, IL-1β and IL-6) and prevented phosphorylation of p38-MAPK, IκBα, NF-κB p65, JNK and ERK in mice with lipopolysaccharide (LPS)-induced acute lung injury [59].…”