2008
DOI: 10.1016/j.ejphar.2007.09.011
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Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin

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Cited by 62 publications
(49 citation statements)
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“…As already mentioned, NNMT catalyzes the formation ofN'-methylnicotinamide, therefore, NNMT activity may be involved in regulating the biological activity of this endogenous compound. It has recently become apparent that N'-methylnicotinamide possesses anti-inflammatory (14), anti-thrombotic (15), vasoprotective (16), and gastroprotective (17) properties, and its levels were found altered in some diseases including hepatic cirrhosis (18) and atherosclerosis (19). Increased NNMT expression was detected in chronic obstructive pulmonary disease (COPD) (20)(21), and in Parkinson's disease, in which enhanced enzyme activity seems to lead to the production of toxic N-methylpiridinium compounds that have been advanced as possible neurotoxins underlying nigrostriatal degeneration (22).…”
Section: Discussionmentioning
confidence: 99%
“…As already mentioned, NNMT catalyzes the formation ofN'-methylnicotinamide, therefore, NNMT activity may be involved in regulating the biological activity of this endogenous compound. It has recently become apparent that N'-methylnicotinamide possesses anti-inflammatory (14), anti-thrombotic (15), vasoprotective (16), and gastroprotective (17) properties, and its levels were found altered in some diseases including hepatic cirrhosis (18) and atherosclerosis (19). Increased NNMT expression was detected in chronic obstructive pulmonary disease (COPD) (20)(21), and in Parkinson's disease, in which enhanced enzyme activity seems to lead to the production of toxic N-methylpiridinium compounds that have been advanced as possible neurotoxins underlying nigrostriatal degeneration (22).…”
Section: Discussionmentioning
confidence: 99%
“…In addition to IP analogs, "pleiotropic" releasers of endogenous PGI 2 may have cardiovascular protective effects. These drugs include angiotensinconverting enzyme inhibitors, statins, some ␤-adrenergic receptor-blockers, antiplatelet thienopyridines, some antidiabetic drugs such as metformin (Gryglewski, 2008), and N 1 -methyl-nicotinamide (Bryniarski et al, 2008). IP antagonists are being examined as potential analgesics to replace nonselective COX inhibitors, although there remains a concern for the perturbation of the TXA 2 /PGI 2 balance, which could be greater with IP antagonists than with COX2 inhibitors (Jones et al, 2006).…”
Section: G Modulators Of the Prostacyclin Pathway In The Management mentioning
confidence: 99%
“…Based on the results of this study, we believe that elevated NNMT activity in the liver and other tissues may not be detrimental but that it may promote a compensatory anti-atherosclerotic response. This may be supported by the profile of exogenous MNA's pharmacological activity, including antithrombotic and anti-inflammatory effects mediated by the COX-2/PGI 2 pathway [8,10]. MNA was also shown to reverse endothelial dysfunction and to affect lipid metabolism, but the involvement of the COX-2/PGI 2 pathway was not examined in this regard [5].…”
Section: Discussionmentioning
confidence: 99%
“…NA is a water-soluble vitamin essential for energy supply, cell viability, and resistance to stress or injury [28]. Moreover, it has recently become apparent that MNA, long considered an inactive metabolite of NA, possess anti-thrombotic [10], antiinflammatory [8], gastroprotective [9], and vasoprotective [5] properties.…”
Section: Introductionmentioning
confidence: 99%