Anti-inflammatory effect of Acalypha australis L. via suppression of NF-κB signaling in LPS-stimulated RAW 264.7 macrophages and LPS-induced septic mice

Kim, Hyojung; Joe, Hae-In; Zhang, Zhiyun; Lee, Sang Woo; Lee, Kyou-Young; Kook, Yoon‐Bum; An, Hyo‐Jin

doi:10.1016/j.molimm.2020.01.010

Cited by 23 publications

(12 citation statements)

References 24 publications

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“…Both the red and green extracts when formulated as organogels showed excellent activity against all other bacteria and fungi tested. This is in consonance with previous research [21][22][23] , where it was observed that the leaf extract possessed a broad spectrum of activity on both fungi and bacteria with Gram negative bacteria being more resistant than Gram positive bacteria. 14 "+" indicates growth, "-" indicates no growth…”

Section: Antimicrobial Activity Screeningsupporting

confidence: 92%

Evaluation of the Antimicrobial Effectiveness of Topical Gels Containing Acalypha wilkesiana

2021

TJNPR

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Staphylococcus aureus. 4.5 It has also been used as a cardioprotective agent as well as in the management of diabetes. 6 Other reported uses of A. wilkesiana include treatment of cold, headache, malaria 4 , inflammation and tumours in the breast. 6 Most publications on A. wilkesiana are based on the investigation of its pharmacological action or the support of its use in traditional health through phytochemical analysis of the aqueous, ethanolic or powder extracts. To the best of our knowledge, apart from Oyelami et al, who investigated the efficacy and safety of Acalypha wilkesiana ointment in the treatment of superficial fungal skin infection 2 , none have investigated the formulation of this medicinally active plant into a dosage form for optimized dosing and therapeutic effect. In this study, the antimicrobial (antibacterial and antifungal) properties of A. wilkesiana were determined, the most appropriate gel dosage form for its therapeutic effectiveness was investigated and the effective strength in the dosage form ascertained through minimum inhibitory and zone of inhibition studies. Materials and Methods Solvents and ReagentsTween 80 was purchased from BDH Chemicals, England. Clotrimazole powder BP (> 98%) purity and Levofloxacin powder BP (>98%) were obtained from Drugfield Pharmaceutical company, Ogun State, Nigeria. Carbopol 940 (Shree organics, India), methylparaben, propyl paraben (Sigma-

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Section: Antimicrobial Activity Screeningsupporting

confidence: 92%

Evaluation of the Antimicrobial Effectiveness of Topical Gels Containing Acalypha wilkesiana

2021

TJNPR

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“…Some believe that the overexpression of inflammatory factors is an important cause of inflammation. Therefore, inhibiting a large number of pro-inflammatory cytokines is considered a potential therapeutic strategy to regulate inflammation-related diseases [ 35 , 36 ]. In our study, the values of TNF-α, IL-6, IL-18, IL-1β, MCP-1, and NO in the model group were all higher than those in the vehicle group.…”

Section: Discussionmentioning

confidence: 99%

“…Reducing NO, TNF-α, IL-6, and IL-1β overexpression helps reduce inflammation [ 15 ]. It has been reported that Acalypha Australis L. can alleviate the damage caused by inflammatory stress through reducing the expression of TNF-α and IL-1β in inflammatory macrophages [ 35 ]. Experiments were also conducted on mice to further investigate the anti-inflammatory effects of SAVEP and obtain additional results.…”

Section: Discussionmentioning

confidence: 99%

Polyphenols Extracted from Shanxi-Aged Vinegar Inhibit Inflammation in LPS-Induced RAW264.7 Macrophages and ICR Mice via the Suppression of MAPK/NF-κB Pathway Activation

et al. 2021

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Shanxi-aged vinegar, a traditional Chinese grain-fermented food that is rich in polyphenols, has been shown to have therapeutic effects on a variety of diseases. However, there has been no comprehensive evaluation of the anti-inflammatory activity of polyphenols extracted from Shanxi-aged vinegar (SAVEP) to date. The anti-inflammatory activities of SAVEP, both in RAW 264.7 macrophages and mice, were extensively investigated for the potential application of SAVEP as a novel anti-inflammatory agent. In order to confirm the notion that polyphenols could improve inflammatory symptoms, SAVEP was firstly detected by gas chromatography mass spectrometry (GC-MS). In total, 19 polyphenols were detected, including 12 phenolic acids. The study further investigated the protective effect of SAVEP on lipopolysaccharide-induced inflammation in RAW264.7 macrophages and ICR mice. The results showed that compared with those of the model group, SAVEP could remarkably recover the inflammation of macrophage RAW264.7 and ICR mice. SAVEP can normalise the expression of related proteins via the suppression of MAPK/NF-κB pathway activation, inhibiting the expression of iNOS and COX-2 proteins, and consequently the production of inflammatory factors, thus alleviating inflammatory stress. These results suggest that SAVEP may have a potential function against inflammation.

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“…Inflammation is a normal immune response that repairs and returns injured tissue to a healthy state in the presence of tissue injury. Nevertheless, an excessive inflammatory response leads to overproduction of inflammatory mediators, which may, in turn, aggravate damage to the local site or even cause life-threatening disorders ( Kim et al, 2020 ). According to the results of transcriptomic analysis, NF-κB is another potential functional target of SCU.…”

Section: Discussionmentioning

confidence: 99%

Protective Property of Scutellarin Against Liver Injury Induced by Carbon Tetrachloride in Mice

et al. 2021

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Liver injury is a clinical disorder caused by toxins, drugs, and alcohol stimulation without effective therapeutic approaches thus far. Scutellarin (SCU), isolated from the edible herb Erigeron breviscapus (Vant.) Hand. -Mazz. showed potential hepatoprotective effects, but the mechanisms remain unknown. In this study, transcriptomics combined with nontargeted metabolomics and 16S rRNA amplicon sequencing were performed to elucidate the functional mechanisms of SCU in carbon tetrachloride (CCl4)–induced liver injury in mice. The results showed that SCU exerted potential hepatoprotective effects against CCl4-induced liver injury by repressing CYP2E1 and IκBα/NF-κB signaling pathways, modulating the gut microbiota (especially enriching Lactobacillus), and regulating the endogenous metabolites involved in lipid metabolism and bile acid homeostasis. SCU originates from a functional food that appears to be a promising agent to guard against liver injury.

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Anti-inflammatory effect of Acalypha australis L. via suppression of NF-κB signaling in LPS-stimulated RAW 264.7 macrophages and LPS-induced septic mice

Cited by 23 publications

References 24 publications

Evaluation of the Antimicrobial Effectiveness of Topical Gels Containing Acalypha wilkesiana

Evaluation of the Antimicrobial Effectiveness of Topical Gels Containing Acalypha wilkesiana

Polyphenols Extracted from Shanxi-Aged Vinegar Inhibit Inflammation in LPS-Induced RAW264.7 Macrophages and ICR Mice via the Suppression of MAPK/NF-κB Pathway Activation

Protective Property of Scutellarin Against Liver Injury Induced by Carbon Tetrachloride in Mice

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