Anti-inflammatory effect of Ajuga bracteosa Wall Ex Benth. mediated through cyclooxygenase (COX) inhibition

Gautam, Raju; Jachak, Sanjay M.; Saklani, Arvind

doi:10.1016/j.jep.2010.11.003

Cited by 79 publications

(45 citation statements)

References 12 publications

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“…histamine and serotonin in early phase; kinin-like substances in intermediate phase; and prostaglandins in late phase [11] . Inhibition of turpentine oil-induced joint oedema, suggests the possible effect of EEAB on different phases of inflammation, which in turn could either be due to lipoxygenase and /or cyclooxygenase inhibition as reported previously [6,7] .…”

Section: Discussionsupporting

confidence: 71%

“…ajugarin I, lupulin A, withaferin A, reptoside and 6-deoxyharpagide was further confirmed using in vitro inhibition assay for COX-1 and COX-2. It was proposed that the anti-inflammatory activity of EEAB is mediated through the inhibition of COX-1 and COX-2 [7] . Thus, reduction in eicosanoids synthesis due to COX inhibition is assumed to account for the beneficial effects of EEAB in the present experiment.…”

Section: Discussionmentioning

confidence: 99%

“…The topical anti-inflammatory activity was well supplemented with the in vitro cyclooxygenase (COX) inhibitory activity of EEAB and its isolated constituents i.e. ajugarin I, lupulin A, withaferin A, reptoside and 6-deoxyharpagide [7] . Based on information from previous literature and considering the topical anti-inflammatory along with in vitro COX inhibitory potential, the present study was undertaken to evaluate the plausible effect of EEAB against acute and chronic arthritis in albino rats as animal model.…”

Section: Introductionmentioning

confidence: 99%

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Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats

Kaithwas

Gautam

Jachak

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats

Kaithwas

Gautam

Jachak

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…The acute inflammatory response in the knee joint of rat stimulated by turpentine oil was reduced in a dose-dependent approach by oral administration of B. calliobotrys at 50, 100 and 200 mg/kg (Table II). The doable inhibitory effect of B. calliobotrys on different phases of inflammation elicited in turpentine oil-induced joint edema might be due to inhibition of either lipoxygenase or cyclooxygenase enzymes (Riaz et al, 2007;Gautam et al, 2011). Formaldehyde induced arthritis is one of most commonly used acute non-immunological arthritis model for investigating the anti-arthritic potential and anti-proliferative activity of a plant extract (Greenwald, 1991).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of in vitro and in vivo anti-arthritic potential of Berberis calliobotrys

Alamgeer

Hasan

Uttra

et al. 2015

Bangladesh J Pharmacol

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The present study was commenced to evaluate the anti-arthritic effect of 70% methanol extract and n-butanol and aqueous fractions of Berberis calliobotrys using both in vitro and in vivo arthritis models. Extract and fractions were investigated in vitro for inhibition of protein (bovine serum and egg albumin) denaturation and human red blood cell membrane stabilization. In vivo anti-arthritic activity of extract and fractions at 50, 100 and 200 mg/kg was assessed using turpentine oil and formaldehyde-induced arthritis, while, 200 mg/kg dose was evaluated against complete Freund’s adjuvant-induced arthritis. B. calliobotrys produced significant (p<0.001) dose dependent inhibition of protein denaturation and human red blood cell membrane stabilization. In turpentine oil, formaldehyde and complete Freund’s adjuvant-induced arthritis models, B. calliobotrys significantly (p<0.001) reduced joint and paw swelling. B. calliobotrys markedly improved body weight, hematology profile, radiological and histopathological parameters in complete Freund’s adjuvant model. It could be concluded that B. calliobotrys holds anti-arthritic potential, supporting its traditional use in treatment of rheumatoid arthritis.

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“…is a highly valued endangered medicinal herb of the family Labiatae (Lamiaceae), distributed in subtropical and temperate regions from Kashmir to Nepal in western Himalaya at an altitude of 1300-2000 m in Bhutan, Pakistan, Afghanistan, China and Malaysia (Arfan et al 1996;Gautam et al 2011). It is found in northern hilly areas of Pakistan and locally called as ''Kori Booti'' due to its acrid taste (Arfan et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Impacts of methyl jasmonate and phenyl acetic acid on biomass accumulation and antioxidant potential in adventitious roots of Ajuga bracteosa Wall ex Benth., a high valued endangered medicinal plant

Saeed

Ali

Khan

et al. 2017

Physiol Mol Biol Plants

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Ajuga bracteosa is a medicinally important plant globally used in the folk medicine against many serious ailments. In the present study, effects of two significant elicitors, methyl jasmonate (Me-J) and phenyl acetic acid (PAA) were studied on growth parameters, secondary metabolites production, and antioxidant potential in adventitious root suspension cultures of A. bracteosa. The results showed a substantial increase in biomass accumulation, exhibiting longer log phases of cultures growth in response to elicitor treatments, in comparison to control. Maximum dry biomass formation (8.88 DW g/L) was recorded on 32nd day in log phase of culture when 0.6 mg/L Me-J was applied; however, PAA at 1.2 mg/L produced maximum biomass (8.24 DW g/L) on day 40 of culture. Furthermore, we observed the elicitors-induced enhancement in phenolic content (total phenolic content), flavonoid content (total flavonoid content) and antioxidant activity (free radical scavenging activity) in root suspension cultures of A. bracteosa. Application of 0.6 mg/L and 1.2 mg/L of Me-J, root cultures accumulated higher TPC levels (3.6 mg GAE/g DW) and (3.7 mg GAE/g DW) in the log phase and stationary phase, respectively, while 2.5 mg/L Me-J produced lower levels (1.4 mg GAE/g DW) in stationary phase of growth stages. Moreover, TFC and FRSA values were found in correspondence to TPC values in the respective growth phases at the similar elicitor treatment. Thus, a feasible protocol for establishment of adventitious roots in A. bracteosa was developed and enhancement in biomass and metabolite content in adventitious root was promoted through elicitation.

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Anti-inflammatory effect of Ajuga bracteosa Wall Ex Benth. mediated through cyclooxygenase (COX) inhibition

Cited by 79 publications

References 12 publications

Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats

Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats

Evaluation of <i>in vitro</i> and <i>in vivo</i> anti-arthritic potential of <i>Berberis calliobotrys</i>

Impacts of methyl jasmonate and phenyl acetic acid on biomass accumulation and antioxidant potential in adventitious roots of Ajuga bracteosa Wall ex Benth., a high valued endangered medicinal plant

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