Abstract:Background/Aim. Amalgam has been used for years in dentistry, but controversy on its adverse effects both on local oral / dental tissues and systemic health still exists. When used for retrograde filling in apical surgery, amalgam comes in close contact with periapical tissue and sometimes is responsible for induction of periapical lesion (PL) or its exacerbation. Therefore, our aim was to examine the effect of amalgam on cytotoxicity and production of pro-inflammatory cytokine by cells isolated from PL. Metho… Show more
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