Anti-inflammatory effect of avenanthramides via NF-κB pathways in C2C12 skeletal muscle cells

Kang, Chounghun; Shin, Woo Shik; Yeo, Dongwook; Lim, Wonchung; Zhang, Tianou; Ji, Li Li

doi:10.1016/j.freeradbiomed.2018.01.020

Cited by 42 publications

(38 citation statements)

References 33 publications

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“…The data presented in this article are supportive to the data presented in [1] . Avns has emerged as a widely used natural compound in foods that can control cellular defense against oxidation and inflammation due to inhibition of NF-κB [2] , [3] .…”

Section: Datasupporting

confidence: 89%

“…Using Schrodinger's standard Glide v5.6 protocol, Avns inhibitors were constructed and docked to protein structures without restrictions. To identify key residues associated with molecular recognition, the interaction energy per residue between each docked ligand to residues within 12 Å of the target binding site was evaluated with a constant dielectric constant of 4 [1] .…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…The stability of the simulation was evaluated by monitoring the CαRMSD (Root-mean-square deviation of α-carbon) with respect to the minimized starting structure. For IKKβ consisting of the kinase domain (KD), ubiquitin-like domain (ULD) and scaffold/dimerization domain (SDD), CαRMSD was evaluated for the ligand binding KD domain [1] . This work was supported by INHA UNIVERSITY Research Grant.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

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Data on the mode of binding between avenanthramides and IKKβ domains in a docking model

et al. 2018

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The data presented in this article are related to the research paper entitled “Anti-inflammatory effect of avenanthramides via NF-κB pathways in C2C12 skeletal muscle cells.” (Kang et al., in press) [1] This article includes experimental procedures used to analyze the mode of binding between and IkB kinase (IKKβ) and avenanthramides which are a group of phenolic alkaloids found in oats. The protein-ligand docking and the computer simulation method of molecular dynamics (MD) for studying the physical interactions of molecules were performed.

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Section: Datasupporting

confidence: 89%

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

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Data on the mode of binding between avenanthramides and IKKβ domains in a docking model

et al. 2018

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“…AVC may increase the total amount of NAD + in A549 cells, which could activate SIRT1 to downregulate acetylated NF-κB. Previous studies have shown that AVC is an allosteric protein-protein inhibitor for modulating IKKβ's affinities (Kang et al 2018) and inhibits the Figure 2. SIRT1 activation is required for the AVC-mediated inhibition of hypoxia-induced COX-2 expression.…”

Section: Discussionmentioning

confidence: 99%

“…Although a recent study showed that AV downregulated the expression of the hypoxia-inducible factor-1α (HIF-1α) gene in cancer cell lines, (Kang et al 2018) the effects of AVC on hypoxic signaling has not been investigated so far. HIF-1α has a critical role in hypoxia; (Guo et al 2008) however, we did not examine the involvement of HIF-1α signaling in this study.…”

Section: Discussionmentioning

confidence: 99%

Avenanthramide C suppresses hypoxia-induced cyclooxygenase-2 expression through sirtuin1 activation in non-small-cell lung cancer cells

Lim

Kang

2020

Animal Cells and Systems

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Avenanthramide C (AVC), found mainly in oats, mediates anti-inflammatory activities by reducing the anti-inflammatory cytokine levels. This study investigated the effects of AVC on hypoxiainduced cyclooxygenase-2 (COX-2) expression in A549 cells. AVC suppressed the hypoxiainduced increase in COX-2 protein levels and promoter activity. We also observed that the effects of AVC were reversed by a SIRT1 inhibitor, indicating that the inhibitory effects of AVC on hypoxia-induced COX-2 expression are mediated by SIRT1. Therefore, AVC inhibits the hypoxic induction of COX-2 expression via SIRT1 activation. Our results suggest that AVC could be beneficial for preventing lung inflammation under hypoxia.

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Redox signaling at the crossroads of human health and disease

Zuo

Zhang

Luo

et al. 2022

MedComm

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Redox biology is at the core of life sciences, accompanied by the close correlation of redox processes with biological activities. Redox homeostasis is a prerequisite for human health, in which the physiological levels of nonradical reactive oxygen species (ROS) function as the primary second messengers to modulate physiological redox signaling by orchestrating multiple redox sensors. However, excessive ROS accumulation, termed oxidative stress (OS), leads to biomolecule damage and subsequent occurrence of various diseases such as type 2 diabetes, atherosclerosis, and cancer. Herein, starting with the evolution of redox biology, we reveal the roles of ROS as multifaceted physiological modulators to mediate redox signaling and sustain redox homeostasis. In addition, we also emphasize the detailed OS mechanisms involved in the initiation and development of several important diseases. ROS as a double‐edged sword in disease progression suggest two different therapeutic strategies to treat redox‐relevant diseases, in which targeting ROS sources and redox‐related effectors to manipulate redox homeostasis will largely promote precision medicine. Therefore, a comprehensive understanding of the redox signaling networks under physiological and pathological conditions will facilitate the development of redox medicine and benefit patients with redox‐relevant diseases.

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Anti-inflammatory effect of avenanthramides via NF-κB pathways in C2C12 skeletal muscle cells

Cited by 42 publications

References 33 publications

Data on the mode of binding between avenanthramides and IKKβ domains in a docking model

Data on the mode of binding between avenanthramides and IKKβ domains in a docking model

Avenanthramide C suppresses hypoxia-induced cyclooxygenase-2 expression through sirtuin1 activation in non-small-cell lung cancer cells

Redox signaling at the crossroads of human health and disease

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