Anti-inflammatory Effect of Cinnamaldehyde in Helicobacter pylori Induced Gastric Inflammation

Muhammad, Jibran Sualeh; Zaidi, Syed Faisal; Shaharyar, Saeeda; Refaat, Alaa; Usmanghani, Khan; Saiki, Ikuo; Sugiyama, Toshiro

doi:10.1248/bpb.b14-00609

Cited by 74 publications

(44 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cinnamomum cassia significantly inhibited IL-8 secretion in H. pylori-and TNF-α-stimulated AGS cells in a dose-dependent manner (Zaidi et al, 2012). Cinnamaldehyde, as a major active component of C. cassia, could suppress inflammation by inhibiting the IL-8 expression in H. pylori-infected AGS cells, via inhibiting NF-κB activation (Muhammad et al, 2015). Cinnamomum osmophloeum extracts, which contained primarily trans-cinnamaldehyde and four minor compounds, could dosedependently suppress the growth of H. pylori in vitro.…”

Section: Anti-inflammatory Activitymentioning

confidence: 97%

Natural Products for the Prevention and Management of Helicobacter pylori Infection

Liu

Meng

et al. 2018

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Helicobacter pylori is the main pathogen that induces chronic gastritis, peptic ulcers, atrophic gastritis, and other gastric disorders, and it is classified as a group I carcinogen. To eradicate H. pylori infection, triple therapy consisting of two antibiotics and a proton pump inhibitor is the most widely recommended first-line therapeutic strategy. Antimicrobial resistance to antibiotics contained in triple therapy could lead to therapeutic regimen failures. Recent studies showed that many natural products, including fruits, vegetables, spices, and medicinal plants, possess inhibitory effects on H. pylori, indicating their potential to be alternatives to prevent and manage H. pylori infection. This review summarizes the effects of natural products on H. pylori infection and highlights the mechanisms of action.

show abstract

Section: Anti-inflammatory Activitymentioning

confidence: 97%

Natural Products for the Prevention and Management of Helicobacter pylori Infection

Liu

Meng

et al. 2018

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

show abstract

“…O principal componente deste óleo essencial é o aldeído cinâmico, o qual apresenta atividade antibacteriana frente a Helicobacterpyloriem uma concentração de 500 µM, além dos seus efeitos anti-inflamatórios 16 . Outros estudos determinaram a CIM dos óleos essenciais de citronela e da casca da canela, as quais variaram entre 560 µg/mL a 78 µg/mL, principalmente frente a cepas de C. albicans, microrganismos prevalente na candidose oral 18,20 .…”

Section: Discussionunclassified

“…A presença destes fitoconstituintes, em algumas espécies, podem representar efeito antimicrobiano, a exemplo de algumas já estudadas como P. granatum Linn (romã), Melaleucaalternifolia e Schinusterebinthifolius (aroeira vermelha) 8,9,15 . Entretanto, outros produtos de origem natural não têm sido extensivamente investigados quanto ao seu potencial antimicrobiano, principalmente pela presença de compostos como aldeído cinâmico em espécies como Cinnamomumcassia, e Cinnamomum zeylanicum 16 . Espécies tropicais como CymbopogonwinterianusePersea americana, apresentam alguns resultados quanto a ação antimicrobiana 17,18 , entretanto não demonstram resultados consistentes acerca deste efeito, principalmente sobre gênero Candida.…”

Section: Introductionunclassified

Atividade Inibitória De Óleos Essenciais Vegetais Frente À Candida Glabrata, Resistente a Fluconazol

ALMEIDA¹,

PAULA²,

ALMEIDA-MARQUES³

et al. 2017

Rev. bras. ciênc. Saúde

View full text Add to dashboard Cite

“…GES-1 and HP coculture was carried out as described previously. 22 Briefly, GES-1 cells were seeded onto 10-cm culture dishes and grown for 24 hours; these cultures were then washed with phosphatebuffered saline (PBS) three times before coculture. Fresh RPMI 1640 medium without antibiotics or FBS was added 1 hour before addition of HP.…”

Section: Bacterial Strains and Culture Coculture Conditionsmentioning

confidence: 99%

Transient receptor potential vanilloid 4 (TRPV4) silencing in Helicobacter pylori‐infected human gastric epithelium

et al. 2016

Self Cite

View full text Add to dashboard Cite

Background Helicobacter pylori (HP) infection induces methylation silencing of specific genes in gastric epithelium. Various stimuli activate the nonselective cation channel TRPV4, which is expressed in gastric epithelium where it detects mechanical stimuli and promotes ATP release. As CpG islands in TRPV4 are methylated in HP‐infected gastric epithelium, we evaluated HP infection‐dependent changes in TRPV4 expression in gastric epithelium.Materials and MethodsHuman gastric biopsy samples, a human gastric cancer cell line (AGS), and a normal gastric epithelial cell line (GES‐1) were used to detect TRPV4 mRNA and protein expression by RT‐PCR and Western blotting, respectively. Ca2+ imaging was used to evaluate TRPV4 ion channel activity. TRPV4 methylation status was assessed by methylation‐specific PCR (MSP). ATP release was measured by a luciferin‐luciferase assay.Results TRPV4 mRNA and protein were detected in human gastric biopsy samples and in GES‐1 cells. MSP and demethylation assays showed TRPV4 methylation silencing in AGS cells. HP coculture directly induced methylation silencing of TRPV4 in GES‐1 cells. In human samples, HP infection was associated with TRPV4 methylation silencing that recovered after HP eradication in a time‐dependent manner.Conclusion HP infection‐dependent DNA methylation suppressed TRPV4 expression in human gastric epithelia, suggesting that TRPV4 methylation may be involved in HP‐associated dyspepsia.

show abstract

Anti-inflammatory Effect of Cinnamaldehyde in Helicobacter pylori Induced Gastric Inflammation

Cited by 74 publications

References 43 publications

Natural Products for the Prevention and Management of Helicobacter pylori Infection

Natural Products for the Prevention and Management of Helicobacter pylori Infection

Atividade Inibitória De Óleos Essenciais Vegetais Frente À Candida Glabrata, Resistente a Fluconazol

Transient receptor potential vanilloid 4 (TRPV4) silencing in Helicobacter pylori‐infected human gastric epithelium

Contact Info

Product

Resources

About