Anti-Inflammatory Effect of Ethanol Extract from Grateloupia crispata on Lipopolysaccharide-Induced Inflammatory Responses in RAW 264.7 Cells and Mice Ears

Bae, Nan-Young; Kim, Minji; Kim, Koth-Bong Woo-Ri; Park, Sun-Hee; Jang, Miran; Ahn, Dong-Hyun

doi:10.3746/jkfn.2016.45.8.1090

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“…Recently, studies on the anti-inflammatory activity of algae have been reported [9][10][11]. Monostroma crassidermum Tokida is a green alga with a thin fan-shape and a green-yellow blade.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of Monostroma crassidermum Tokida Ethanol Extract on Lipopolysaccharide-Stimulated RAW 264.7 Cells and Mice Ear Edema

Kim

Kang

Jeong

et al. 2023

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In this study, the anti-inflammatory effects of Monostroma crassidermum Tokida ethanol extract (MCEE) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and croton oil-stimulated ICR mouse models were investigated. MCEE reduced the secretion of pro-inflammatory cytokines, including interleukin-6, IL-1β, tumor necrosis factor-α, and nitric oxide, which are non-toxic to RAW 264.7 cells. In vivo testing showed that the results in the MCEE-treated group (10-250 mg/kg. body weight) were similar to those in the prednisolone-treated group (10 mg/kg. body weight). Photomicrographs showed that the skin layer was thinned, and mast cell infiltration was reduced in the mouse-ear tissue. Therefore, these results suggested that MCEE exerts an anti-inflammatory effect, indicating the possible applications of MCEE as a natural anti-inflammatory material.

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“…Recently, studies on the anti-inflammatory activity of algae have been reported [9][10][11]. Monostroma crassidermum Tokida is a green alga with a thin fan-shape and a green-yellow blade.…”

Section: Introductionmentioning

confidence: 99%