Anti-Inflammatory Effect of Exercise Mediated by Toll-Like Receptor Regulation in Innate Immune Cells – A Review

Collao, Nicolás; Rada, Isabel; Francaux, Marc; Deldicque, Louise; Zbinden‐Foncea, Hermann

doi:10.1080/08830185.2019.1682569

Cited by 54 publications

(34 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Both an acute bout of aerobic exercise (23) as well as resistance-based training (24) decrease the expression of TLR4 on the surface of monocytes. As circulating monocytes are the precursors to tissue macrophages, the exercise-induced decreases in monocyte TLR4 expression may be an important mechanism by which the anti-inflammatory effects of exercise are mediated (25,26), specifically in patients with chronic low-grade inflammation, such as patients with obesity and/or diabetes (27). In addition to attenuating the production of proinflammatory cytokines induced by TLR signaling, exercise stimulates the release of anti-inflammatory cytokines.…”

Section: Does High Cardiorespiratory Fitness Boost Immunity and Attenmentioning

confidence: 99%

Does High Cardiorespiratory Fitness Confer Some Protection Against Proinflammatory Responses After Infection by SARS‐CoV‐2?

Zbinden‐Foncea

Francaux

Deldicque

et al. 2020

Obesity

Self Cite

166

144

View full text Add to dashboard Cite

show abstract

Section: Does High Cardiorespiratory Fitness Boost Immunity and Attenmentioning

confidence: 99%

Does High Cardiorespiratory Fitness Confer Some Protection Against Proinflammatory Responses After Infection by SARS‐CoV‐2?

Zbinden‐Foncea

Francaux

Deldicque

et al. 2020

Obesity

Self Cite

166

144

View full text Add to dashboard Cite

show abstract

“…In this context, the protective effect of physical activity is assumed to be a reduced expression of TLRs [22] followed by reduced proinflammatory activation. In particular, a reduced expression of TLR2 and TLR4 has been found after both acute as well as regular exercise [48,49,53,54].…”

Section: Effects Of Exercise On Inflammagingmentioning

confidence: 99%

“…With regard to inflammaging, toll-like receptors (TLRs) have been gaining increasing attention, because the upregulation of these receptors is associated with physical inactivity, systemic inflammation, and the development of age-associated diseases [48]. TLRs are transmembrane type I glycoproteins, which are mostly expressed in cells of the innate immune system [49].…”

Section: Effects Of Exercise On Inflammagingmentioning

confidence: 99%

Physical Activity and Diet Shape the Immune System during Aging

2020

View full text Add to dashboard Cite

With increasing age, the immune system undergoes a remodeling process, termed immunosenescence, which is accompanied by considerable shifts in leukocyte subpopulations and a decline in various immune cell functions. Clinically, immunosenescence is characterized by increased susceptibility to infections, a more frequent reactivation of latent viruses, decreased vaccine efficacy, and an increased prevalence of autoimmunity and cancer. Physiologically, the immune system has some adaptive strategies to cope with aging, while in some settings, maladaptive responses aggravate the speed of aging and morbidity. While a lack of physical activity, decreased muscle mass, and poor nutritional status facilitate immunosenescence and inflammaging, lifestyle factors such as exercise and dietary habits affect immune aging positively. This review will discuss the relevance and mechanisms of immunoprotection through physical activity and specific exercise interventions. In the second part, we will focus on the effect of dietary interventions through the supplementation of the essential amino acid tryptophan, n-3 polyunsaturated fatty acids, and probiotics (with a special focus on the kynurenine pathway).

show abstract

“…PA performed regularly and at moderate intensity (~ 60% VO 2 max to 60 min) stimulates the immune system by improving the function and action of tissue macrophages and promoting the activation and recirculation of key immune system factors, such as immunoglobulins, anti-inflammatory cytokines, neutrophils, NK cells, cytotoxic T cells and immature B cells. At molecular level, moderate PA induces downregulation of TLR expression and/or inhibition of TLR activation, in particular reduction of monocyte TLR4 expression (Collao et al 2020 ).…”

Section: Impact Of Physical Exercise On Organs’ Response To Viral Infmentioning

confidence: 99%

Molecular mechanisms involved in the positive effects of physical activity on coping with COVID-19

et al. 2020

View full text Add to dashboard Cite

Purpose Physical activity (PA) represents the first line of defence against diseases characterised by increased inflammation status, such as metabolic and infectious diseases. Conversely, a sedentary lifestyle-associated with obesity, type 2 diabetes and cardiovascular disorders-negatively impacts on general health status, including susceptibility to infections. At a time of a pandemic SARS-CoV2 infection, and in the context of the multiorgan crosstalk (widely accepted as a mechanism participating in the pathophysiology of all organs and systems), we examine the complex interplay mediated by skeletal muscle contraction involving the immune system and how this contributes to control health status and to counteract viral infections. In so doing, we review the molecular mechanisms and expression of molecules modulated by PA, able to provide the proper molecular equipment against viral infections such as the current SARS-CoV2. Methods A critical review of the literature was performed to elucidate the molecular mechanisms and mediators induced by PA that potentially impact on viral infections such as SARS-CoV2. Results We showed the effects mediated by regular moderate PA on viral adverse effects through the regulation of biological processes involving the crosstalk between skeletal muscle, the immune system and adipose tissue. Evidence was provided of the effects mediated by modulation of the expression of inflammation markers. Conclusion A tigth association between PA and reduction in inflammation status allows effective counteracting of SARS-CoV2 infection. It is therefore essential to persuade people to keep active.

show abstract

Anti-Inflammatory Effect of Exercise Mediated by Toll-Like Receptor Regulation in Innate Immune Cells – A Review

Cited by 54 publications

References 124 publications

Does High Cardiorespiratory Fitness Confer Some Protection Against Proinflammatory Responses After Infection by SARS‐CoV‐2?

Does High Cardiorespiratory Fitness Confer Some Protection Against Proinflammatory Responses After Infection by SARS‐CoV‐2?

Physical Activity and Diet Shape the Immune System during Aging

Molecular mechanisms involved in the positive effects of physical activity on coping with COVID-19

Contact Info

Product

Resources

About