Anti-inflammatory effect of exercise training through reducing inflammasome activation-related inflammatory cytokine levels in overweight/obese populations: A systematic review and meta-analysis

Yi, Ding; Xu, Xi

doi:10.1016/j.ctcp.2022.101656

Cited by 11 publications

(6 citation statements)

References 52 publications

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“…This increased concentration of anti-inflammatory cytokines results from the production of IL-6 following PA [107]. Together with this IL-6 production, PA may inhibit other inflammatory factors like IL-1β and TNFα and this can result in changes to hormonal status, PA intensity, and PA duration [107,108]. A meta-analysis focusing on overweight and obese adults indicated that PA in association with caloric restriction can be more efficient than caloric restriction alone to reduce TNFα levels.…”

Section: The Link Between Pops Pa and Inflammatory Functionmentioning

confidence: 99%

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Serrano,

Le Garf,

Martin

et al. 2024

IJMS

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Obesity affects nearly 660 million adults worldwide and is known for its many comorbidities. Although the phenomenon of obesity is not fully understood, science regularly reveals new determinants of this pathology. Among them, persistent organic pollutants (POPs) have been recently highlighted. Mainly lipophilic, POPs are normally stored in adipose tissue and can lead to adverse metabolic effects when released into the bloodstream. The main objective of this narrative review is to discuss the different pathways by which physical activity may counteract POPs’ adverse effects. The research that we carried out seems to indicate that physical activity could positively influence several pathways negatively influenced by POPs, such as insulin resistance, inflammation, lipid accumulation, adipogenesis, and gut microbiota dysbiosis, that are associated with the development of obesity. This review also indicates how, through the controlled mobilization of POPs, physical activity could be a valuable approach to reduce the concentration of POPs in the bloodstream. These findings suggest that physical activity should be used to counteract the adverse effects of POPs. However, future studies should accurately assess its impact in specific situations such as bariatric surgery, where weight loss promotes POPs’ blood release.

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Section: The Link Between Pops Pa and Inflammatory Functionmentioning

confidence: 99%

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Serrano,

Le Garf,

Martin

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Moreover, the combined of Yijinjing and resistance training has proven effective in inhibiting the robust NLRP3 inflammasome activation, thereby alleviating insulin resistance and liver injury in elderly pre-diabetes ( 108 ). Research has also shown that exercise can exert an anti-inflammatory effect by reducing circulating levels of inflammasome activation-related inflammatory cytokines IL-1β and IL-18 in overweight/obese populations ( 109 ). Similarly, a previous study has demonstrated that a 12-week strength and endurance combined training significantly inhibited the activation of the NLRP3 signaling pathway in obese children ( 110 ) (as shown in Supplementary Table 1 and Figure 2 ).…”

Section: Exercise On Improving Diabetic Complications By Targeting Py...mentioning

confidence: 99%

“…Evidence shows that 12 weeks of Tai Chi intervention effectively alleviated glucose homeostasis and inhibited the expression of the NLRP3 inflammatory signal pathway in middle-aged and elderly pre-diabetic patients (107). Moreover, the combined of Yijinjing and resistance training has proven effective in inhibiting the robust NLRP3 inflammasome activation, thereby alleviating insulin resistance and liver injury in elderly pre-diabetes (108). Research has also shown that exercise can exert an anti-inflammatory effect by reducing circulating levels of inflammasome activation-related inflammatory cytokines IL-1b and IL-18 in overweight/obese populations (109).…”

Section: The Clinical Implications Of Exercise On Treat Dm and Its Co...mentioning

confidence: 99%

Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications

Li,

Zhang,

Wang

et al. 2023

Front. Endocrinol.

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Diabetes mellitus (DM) and its complications are important, worldwide public health issues, exerting detrimental effects on human health and diminishing both quality of life and lifespan. Pyroptosis, as a new form of programmed cell death, plays a critical role in DM and its complications. Exercise has been shown to be an effective treatment for improving insulin sensitivity or preventing DM. However, the molecular mechanisms underlying the effects of exercise on pyroptosis-related diseases remain elusive. In this review, we provided a comprehensive elucidation of the molecular mechanisms underlying pyroptosis and the potential mechanism of exercise in the treatment of DM and its complications through the modulation of anti-pyroptosis-associated inflammasome pathways. Based on the existing evidence, further investigation into the mechanisms by which exercise inhibits pyroptosis through the regulation of inflammasome pathways holds promising potential for expanding preventive and therapeutic strategies for DM and facilitating the development of novel therapeutic interventions.

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“…This increased concentration of anti-inflammatory cytokines would result from the production of IL-6 following PA [104]. Together with this IL-6 production, PA may inhibit other inflammatory factors like IL-1β and TNFα and results can change following sex, PA intensity and PA duration [104,105]. A meta-analysis focusing on overweight and obese adults indicated that PA in association with caloric restriction can be more efficient than caloric restriction alone to reduce TNFα levels.…”

Section: The Link Between Pops Pa and Inflammatory Functionmentioning

confidence: 99%

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Serrano,

Le Garf,

Martin

et al. 2023

Preprint

View full text Add to dashboard Cite

Obesity affects nearly 660 million adults worldwide and is known for its many comorbidities. Although the phenomenon of obesity is not fully understood, science regularly reveals new determinants of this pathology. Among them, the persistent organic pollutants (POPs) have been recently highlighted. Mainly lipophilic, POPs are normally stored in adipose tissue and can lead to adverse metabolic effects when released into the bloodstream. The main objective of this narrative review is to discuss the different pathways by which physical activity may counteract POPs adverse effects. The research that we carried out seems to indicate that physical activity could positively influence several pathways negatively influenced by POPs, such as insulin resistance, inflammation, lipid accumulation, adipogenesis and gut microbiota dysbiosis that are associated with the development of obesity. This review also indicates how, through the controlled mobilization of POPs, physical activity could be a valuable approach to reduce the concentration of POPs in the bloodstream. These findings suggest that physical activity should be used to counteract the adverse effects of POPs. However, future studies should accurately assess its impact in specific situations such as bariatric surgery where weight loss promotes POPs blood release.

show abstract

Anti-inflammatory effect of exercise training through reducing inflammasome activation-related inflammatory cytokine levels in overweight/obese populations: A systematic review and meta-analysis

Cited by 11 publications

References 52 publications

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

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