Anti-inflammatory effect of fucoxanthin on dextran sulfate sodium-induced colitis in mice

Yang, Yuan‐Ping; Tong, Qiao-Yun; Zheng, Shi-Hua; Zhou, Mi; Zeng, You-Meng; Zhou, Tingting

doi:10.1080/14786419.2018.1528593

Cited by 50 publications

(36 citation statements)

References 14 publications

(1 reference statement)

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“…The results revealed that the FX-mediated anti-inflammation function is associated with the activation of NF-κB ( Figures 5 – 9 ), which is consistent with the findings of previous studies, and have shown that FX can inhibit NO synthase and cyclooxygenase protein, and reduced the expression of NO and prostaglandin E2 levels, by inhibiting the activation of NF-κB and phosphorylation of MAPK (Kim et al, 2010). Numerous studies have reported that FX suppresses LPS-induced overexpression of iNOS and COX-2, as well as pro-inflammatory cytokines production in vitro and in vivo (Shiratori et al, 2005; Kim et al, 2010; Heo et al, 2012; Islam et al, 2013; Lee et al, 2013; Pangestuti et al, 2013; Robertson et al, 2015; Choi et al, 2016; Zhao et al, 2017; Jiang et al, 2018; Jung et al, 2018; Yang et al, 2018), which is similar to our findings. As the previous studies reported, the anti-inflammatory mechanism of FX involved NF-κB pathways (Kim et al, 2010b; Robertson et al, 2015; Zhao et al, 2017; Jiang et al, 2018).…”

Section: Discussionsupporting

confidence: 92%

Fucoxanthin, a Marine Xanthophyll Isolated From Conticribra weissflogii ND-8: Preventive Anti-Inflammatory Effect in a Mouse Model of Sepsis

Guo

Huang

et al. 2019

Front. Pharmacol.

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Background: Fucoxanthin (FX), a xanthophyll pigment which occurs in marine brown algae with remarkable biological properties, has been proven to be safe for consumption by animals. Although FX has various pharmacological effects including anti-inflammatory, anti-tumor, anti-obesity, antioxidant, anti-diabetic, anti-malarial, and anti-lipid, in vivo protective effect against sepsis has not been reported. In this study, we aimed at evaluation the efficacy of the FX in a model of sepsis mouse. Methods: FX was successfully isolated from Conticribra weissflogii ND-8 for the first time. The FX was identified by thin-layer chromatography (TLC), high-performance liquid chromatography-mass spectrometry (HPLC-MS), and nuclear magnetic resonance (NMR). Animals were randomly divided into 9 groups, including Sham group (mouse received an intraperitoneal injection of normal saline 1.0 ml/kg), FX-treated (0.1–1.0 ml/kg), Lipopolysaccharide (LPS)-treated (20 mg/kg), FX+LPS-treated (0.1–10.0 mg/kg and 20 mg/kg, respectively), and urinastatin groups (10 4 U/kg). Nuclear factor (NF)-κB activation could be potential treatment for sepsis. NF-κB signaling components were determined by western-blotting. IL-6, IL-1β, TNF-α production, and NF-κB activation were evaluated by ELISA and immunofluorescent staining in vitro . Results: FX was found to decrease the expression of inflammatory cytokines including IL-6, IL-1β, and TNF-α, in a prophylactic manner in the LPS-induced sepsis mouse model. Meanwhile, FX significantly inhibits phosphorylation of the NF-κB signaling pathway induced by LPS at the cellular level and reduces the nuclear translocation of NF-κB. The IC 50 for suppressing the expression of NF-κB was 11.08 ± 0.78 μM in the THP1-Lucia™ NF-κB cells. Furthermore, FX also inhibits the expression of inflammatory factors in a dose-dependent manner with the IC 50 inhibition of IL-6 production was 2.19 ± 0.70 μM in Raw267.4 macrophage cells. It is likely that the molecules with the ability of targeting NF-κB activation and inflammasome assembly, such as fucoxanthin, are interesting subjects to be used for treating sepsis.

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Section: Discussionsupporting

confidence: 92%

Fucoxanthin, a Marine Xanthophyll Isolated From Conticribra weissflogii ND-8: Preventive Anti-Inflammatory Effect in a Mouse Model of Sepsis

Guo

Huang

et al. 2019

Front. Pharmacol.

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“…Fucoxanthin preventive anti-inflammatory effect in a mouse model of Sepsis is associated with the regulation of NF-κB signaling [20]. Fucoxanthin downregulates the DSS-induced expression of COX-2 and NF-κB in mice [21]. Fucoxanthin inhibited LPSinduced overexpression of pro-inflammatory cytokines (IL-1β, IL-6, iNOS, COX-2, and TNF-α) via the AMPK/NF-κB signaling pathway [16].…”

Section: Introductionmentioning

confidence: 99%

Fucoxanthin attenuates LPS-induced acute lung injury via inhibition of the TLR4/MyD88 signaling axis

Huang

Liu

et al. 2020

Aging

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Acute lung injury (ALI) is a critical clinical condition with a high mortality rate. It is believed that the inflammatory storm is a critical contributor to the occurrence of ALI. Fucoxanthin is a natural extract from marine seaweed with remarkable biological properties, including antioxidant, anti-tumor, and anti-obesity. However, the anti-inflammatory activity of Fucoxanthin has not been extensively studied. The current study aimed to elucidate the effects and the molecular mechanism of Fucoxanthin on lipopolysaccharide-induced acute lung injury. In this study, Fucoxanthin efficiently reduced the mRNA expression of pro-inflammatory factors, including IL-10, IL-6, iNOS, and Cox-2, and down-regulated the NF-κB signaling pathway in Raw264.7 macrophages. Furthermore, based on the network pharmacological analysis, our results showed that anti-inflammation signaling pathways were screened as fundamental action mechanisms of Fucoxanthin on ALI. Fucoxanthin also significantly ameliorated the inflammatory responses in LPS-induced ALI mice. Interestingly, our results revealed that Fucoxanthin prevented the expression of TLR4/MyD88 in Raw264.7 macrophages. We further validated Fucoxanthin binds to the TLR4 pocket using molecular docking simulations. Altogether, these results suggest that Fucoxanthin suppresses the TLR4/MyD88 signaling axis by targeting TLR4, which inhibits LPS-induced ALI, and fucoxanthin inhibition may provide a novel strategy for controlling the initiation and progression of ALI.

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“…Fucoxanthin, a red marine carotenoid found in seaweeds, has been known to be effective against inflammation, diabetes, cancer, and obesity. In a lipopolysaccharide-induced murine macrophage RAW 264.7 cell model, FX produced an anti-inflammatory effect by inhibition of nitric oxide, prostaglandin, IL-6, IL-8, IL-1β, through NF-kB suppression and MAPK phosphorylation [14]. It has been reported that FX reduces the activity of monocyte chemoattractant protein-1 (MCP-1) [16].…”

Section: Discussionmentioning

confidence: 99%

“…Fucoxanthin (FX), a non-provitamin-A marine carotenoid, is known to possess activities against inflammation, oxidative stress, cancer, diabetes, and obesity. Anti-inflammatory effect of FX has been proved against lipopolysaccharide-induced inflammation in murine RAW 264.7 culture system [14]. Neuroinflammation, induced by amyloid-β42 and lipopolysaccharide in BV2 microglia cells can be regulated through negative feedback by FX [15].…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

Fucoxanthin improves functional recovery of orbitopathy in Graves’ disease by downregulating IL-17 mRNA expression in a mouse model

Chai¹,

Wang²,

Yan³

2020

Trop. J. Pharm Res

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Purpose: To explore the efficacy of fucoxanthin (FX), a carotenoid, against inflammation via inhibition of IL-17 mRNA expression, and its anti-oxidant activity in Graves’ orbitopathy (GO)-induced mice model.Methods: The effects of FX on IL-6, IL-8, IL-17, MCP-1, and TNF-α, in orbital fibroblast tissues extracted from GO-induced BALB/c mice was investigated. Anti-oxidative stress markers, 8-hydroxy-2’- deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels were quantified in tear samples collected from GO-induced FX treated mice.Results: FX administration in cultured human orbital fibroblast cells revealed almost complete cell viability and no cell apoptosis. FX resulted in IL-1β induced Beclin-1 and Atg-5 silencing, in cultured human orbital fibroblasts. BALB/c mice immunized with Ad-TSHR289 indicated elevated levels ofthyroid peroxidase and thyroglobulin antibodies in the serum sample. FX predominantly downregulated the mRNA expression of IL-17, and also reduced increased 8-OHdG and MDA in the tear secretion of GO-induced mice.Conclusion: FX may be an effective and useful molecule for the treatment of GO, through its antiinflammatory and anti-oxidative potential, but it requires further investigation to ascertain its therapeutic effectiveness. Keywords: Anti-inflammatory, Anti-oxidant, Fucoxanthin, Graves’ disease, Graves’ orbitopathy, IL-17

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Anti-inflammatory effect of fucoxanthin on dextran sulfate sodium-induced colitis in mice

Cited by 50 publications

References 14 publications

Fucoxanthin, a Marine Xanthophyll Isolated From Conticribra weissflogii ND-8: Preventive Anti-Inflammatory Effect in a Mouse Model of Sepsis

Fucoxanthin, a Marine Xanthophyll Isolated From Conticribra weissflogii ND-8: Preventive Anti-Inflammatory Effect in a Mouse Model of Sepsis

Fucoxanthin attenuates LPS-induced acute lung injury via inhibition of the TLR4/MyD88 signaling axis

Fucoxanthin improves functional recovery of orbitopathy in Graves’ disease by downregulating IL-17 mRNA expression in a mouse model

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