Anti-Inflammatory Effect of Hamamelis Lotion in a UVB Erythema Test

Hughes-Formella, Betsy; Bohnsack, K.; Rippke, Frank; Benner, G.; Rudolph, M.G.; Tausch, I; Gassmueller, J.

doi:10.1159/000017904

Cited by 46 publications

(40 citation statements)

References 6 publications

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“…In fact, 2 MEDs may be too strong an insult while 1 MED may be more useful to monitor the effects of an anti-inflammatory drug. However, in at least another experiment similar to ours, 2 MEDs proved to be effective in detecting the anti-inflammatory activity of topical drugs as weak as Hamamelis virginiana [15]. …”

Section: Discussionmentioning

confidence: 83%

Topical Metronidazole Does Not Abate UVB-Induced Erythema

Guarrera

Brusati²,

Rebora³

2001

Dermatology

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Background: The capacity of topical metronidazole to reduce erythema severity scores in rosacea has been attributed to its anti-inflammatory activity. Methods: Nine healthy subjects were irradiated on three 1-cm² areas on their volar forearm with 2 MEDs of UVB. Twenty-four hours later, one of the irradiated areas was treated daily with metronidazole 1% vanishing cream, one with the vehicle only and the third was left untreated (control). The intensity of erythema was measured, at 24, 48, 72 and 96 h after irradiation, by a Chromameter CR200 (Minolta, Japan) and expressed in the L*a*b* system. The a* parameter was taken as the measure of redness. Results: Overall, redness diminished over time in a linear way, but treatments did not influence it significantly. Conclusion: In our vehicle, metronidazole 1% cream failed to abate the UVB-induced erythema. An activity other than the anti-inflammatory one should be suggested to explain the topical metronidazole efficacy in rosacea.

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Section: Discussionmentioning

confidence: 83%

Topical Metronidazole Does Not Abate UVB-Induced Erythema

Guarrera

Brusati²,

Rebora³

2001

Dermatology

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“…One of the components of the patientʼs ink was H. virginiana, a kind of witch hazel that has been linked to anti-inflammatory properties, especially in cases of photodermatitis [37,38,39,40] and colonic cancer [41,42], due to a molecule called hamamelitannin, with anti-TNF properties (in vitro inhibition of TNF-mediated cell death and DNA fragmentation) [43] and scavenging activity against reactive oxygen species [42,44,45]. Even if it were attractive to assume that H. virginiana could have had an inhibitory effect over the purpuric rash, we would have to presume that functional levels of the active principle still remained in the skin 5 years after its injection, which is to be proven.…”

Section: Discussionmentioning

confidence: 99%

The ‘Sparing Phenomenon' of Purpuric Rash over Tattooed Skin

Pinal‐Fernandez

Soláns-Laqué²

2013

Dermatology

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Cutaneous complications associated with decorative tattooing are well known. However, the inhibition of a purpuric reaction by a tattoo is a fact that, as far as the authors know, has not been described before, fitting the definition of a ‘sparing phenomenon', the absence of manifesting a particular skin disease in an area previously affected by another condition. From the clinical observation of purpuric lesions apparently inhibited by a tattoo in a 26-year-old patient, we performed an exact binomial test on the observed and expected proportion of purpuric lesions inside (0%, 95% confidence interval, CI, 0-2.6%) and outside (100%, 95% CI 97.4-100%) the tattooed skin, demonstrating a nonrandom distribution respecting the tattooed area (p < 0.001) and identifying the composition of the ink used in the tattoo (color pigment, glycerine, Hamamelis virginiana extract, water and alcohol). Moreover, we reviewed the cases of sparing phenomenon described in the literature. In conclusion this is the first report of a sparing phenomenon of purpuric lesions over tattooed skin.

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“…Inhibition of vascular permeability and a vasoconstrictor effect have been observed in animal studies [16]. Reductions in cutaneous blood flow and skin temperature have also been demonstrated in humans [17,18], as has a reduction in UV erythema [19,20]. Studies by the authors using an experimental irritation model (sodium lauryl sulfate irritation test) showed that HM produced significant reductions in skin redness (chromametry a*-value) and cuta- Gloor/Reichling/Wasik/Holzgang neous blood flow (laser doppler).…”

Section: Discussionmentioning

confidence: 99%

Antiseptic Effect of a Topical Dermatological Formulation That Contains Hamamelis Distillate and Urea

Gloor

Reichling²,

Wasik³

et al. 2002

Complement Med Res

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Objective: To determine the antimicrobial activity of a distillate of Hamamelis (Aqua Hamamelidis ), United States Pharmacopoeia (USP) 23, and urea formulated as a topical dermatological preparation that contains both active ingredients. Methods: Using the simple occlusion test and expanded flora test, we conducted in vivo studies in 15 healthy volunteers. We also performed in vitro studies using the agar diffusion test. Results: The occlusion test and expanded flora test demonstrated significant antimicrobial activity for a product containing the Hamamelis distillate (90%) and urea (5%) among other ingredients. The expanded flora test demonstrated significant antimicrobial activity for both Hamamelis distillate and urea. The simple occlusion test showed the same tendency, but results were not significant. The agar diffusion test showed inhibition of Staphylococcus aureus and Candida albicans , among other organisms. Comparison with earlier studies of chlorhexidine digluconate and fuchsine using the same method showed that the antimicrobial activities of Hamamelis distillate and urea were relatively weak. This finding is supported by the weak inhibitory activity observed in the agar diffusion test (using 100% of the finished dosage form). Conclusion: Formulations of Hamamelis distillate and urea are mainly used for their antiinflammatory, hydrating, and barrier-stabilizing effects in dermatitis maintenance therapy. As bacterial colonization has a central role in the pathogenesis of atopic dermatitis and intertrigo, the antimicrobial activity of such products is considered a welcome, added benefit.

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Anti-Inflammatory Effect of Hamamelis Lotion in a UVB Erythema Test

Cited by 46 publications

References 6 publications

Topical Metronidazole Does Not Abate UVB-Induced Erythema

Topical Metronidazole Does Not Abate UVB-Induced Erythema

The ‘Sparing Phenomenon' of Purpuric Rash over Tattooed Skin

Antiseptic Effect of a Topical Dermatological Formulation That Contains Hamamelis Distillate and Urea

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