Anti-Inflammatory Effect of Malva sylvestris, Sida cordifolia, and Pelargonium graveolens Is Related to Inhibition of Prostanoid Production

Martins, Cléverson Antônio Ferreira; Campos, Marcelo Lattarulo; Irioda, Ana Carolina; Stremel, Dile Pontarolo; Trindade, Angela Cristina Leal Badaró; Pontarolo, Roberto

doi:10.3390/molecules22111883

Cited by 38 publications

(19 citation statements)

References 57 publications

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“…In another study, the polyphenol-rich fractions obtained from Sterculia urens produced significant analgesic effects in acetic acid-induced writhing method (Konaté et al, 2013). S. cordifolia also reduced the prostanoid release in macrophage cell model, being verified antinociceptive and antiinflammatory activity in models induced by acetic acid and carrageenan (Martins et al, 2017;Sutradhar, Rahman, Ahmad, & Bachar, 2008).…”

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confidence: 89%

Sida tuberculata extract reduces the nociceptive response by chemical noxious stimuli in mice: Implications for mechanism of action, relation to chemical composition and molecular docking

Rosa

Coelho

Silva

et al. 2018

Phytotherapy Research

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Sida tuberculata R.E.Fr. (Malvaceae) is a medicinal plant widely found in Southern Brazil, and popularly used for inflammatory disorders and to pain relief. A phytochemical analysis followed by an investigation about antinociceptive potential and mechanism of action were performed with leaves and roots extracts. Methanolic extracts, designated as S. tuberculata leaves extract (STLE) and S. tuberculata roots extract, were analyzed both by UHPLC-MS. The in vivo antinociceptive potential of STLE (10-300 mg kg −1 ) was assessed in mice subjected to the acetic acid-induced abdominal writhes and formalin model. Agonist/antagonist tests and computational docking suggest the involvement of opioid and adenosinergic systems. The main chemical class detected on extracts was the ecdysteroids, and 20-hydoxyecdysone (20HE) was confirmed as the major phytoconstituent. The pretreatment with STLE (100 mg kg −1 ) reduced more than 70% abdominal contortions induced by acetic acid model and produced significant inhibition on formalin-induced licking response. The mechanism of action study revealed STLE might act through opioid and adenosine systems. Molecular docking suggested kaempferol derivative and 20HE might interacting with μ-opioid receptor. Thus, the results suggest the existence of antinociceptive potential from S. tuberculata extracts being in accordance to the traditional use.

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confidence: 89%

Sida tuberculata extract reduces the nociceptive response by chemical noxious stimuli in mice: Implications for mechanism of action, relation to chemical composition and molecular docking

Rosa

Coelho

Silva

et al. 2018

Phytotherapy Research

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“…Anti-nociceptive [106], anti-inflammatory [109], antioxidant activity and improved wound healing [107]; Hepatoprotective effects [108].…”

Section: Herbs Of Sida Cordifolia (Indian Mallow)mentioning

confidence: 99%

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

et al. 2020

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Twenty natural remedies traditionally used against different inflammatory diseases were probed for their potential to suppress the expression of the inflammatory markers E-selectin and VCAM-1 in a model system of IL-1 stimulated human umbilical vein endothelial cells (HUVEC). One third of the tested extracts showed in vitro inhibitory effects comparable to the positive control oxozeaenol, an inhibitor of TAK1. Among them, the extract derived from the roots and rhizomes of Peucedanum ostruthium (i.e., Radix Imperatoriae), also known as masterwort, showed a pronounced and dose-dependent inhibitory effect. Reporter gene analysis demonstrated that inhibition takes place on the transcriptional level and involves the transcription factor NF-κB. A more detailed analysis revealed that the P. ostruthium extract (PO) affected the phosphorylation, degradation, and resynthesis of IκBα, the activation of IKKs, and the nuclear translocation of the NF-κB subunit RelA. Strikingly, early effects on this pathway were less affected as compared to later ones, suggesting that PO may act on mechanism(s) that are downstream of nuclear translocation. As the majority of cognate NF-κB inhibitors affect upstream events such as IKK2, these findings could indicate the existence of targetable signaling events at later stages of NF-κB activation.

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“…Malva sylvestris é denominada uma planta herbácea, conhecida como malva, malva branca e malva branca sedosa. Originada no continente Europeu, Africano, Asiático e Americano 2,42,43 .…”

Section: Malva Sylvestrisunclassified

“…Segundo Aleluia et al 2 , essa planta possui propriedades antiinflamatórias, antimicrobianas. Já Martins et al 42 afirmaram que possui aplicação em casos de distúrbios gastrointestinal, doenças dermatológicas, dores menstruais, perturbações urológicas, doenças respiratórias e doenças orais. Seddighfar et al 44 disseram sobre a eficácia da Malva sylvestris na Odontologia em doenças inflamatórias como periodontite, gengivite e abcessos.…”

Section: Malva Sylvestrisunclassified

“…Segundo Martins et al 42 em sua pesquisa afirmaram que a malva apresenta-se como um excelente antiinflamatório, agindo com seletividade em COX-2 e inibição de TXA2. Seddighfar et al 44 disseram que as atividades anti-inflamatórias da Malva sylvestris se dar através da inibição das sínteses de prostaglandinas e mecanismos inibidores centrais, afirmando que este pode ser utilizado como medicamento para controlar dor e inflamação.…”

Section: Malva Sylvestrisunclassified

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Uso de medicamentos fitoterápicos como opção anti-inflamátoria na odontologia

Moreira

2020

J Dent Pub H

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The term phytotherapy comes from the Latin, "phyton" which means plant, and "therapy" related to treatment, whose first handwritten account in 1500 BC entitled "Papers of Ebers". Phytotherapy is the science that uses plants for the treatment of various human diseases. In Brazil, studies show an interest of the Unified Health System (SUS) regarding herbal medicines between the 70s and 80s, mainly in primary health care due to the cost reduction, however few observational studies are found in the literature regarding their use in the system. The present study is a literature review in order to report the main herbal medicines with anti-inflammatory action, as a therapeutic option for patients who cannot or do not wish to use non-steroidal anti-inflammatory drugs (NSAIDs). For its construction, a search was performed for articles in the PubMed, Scielo and BVSalud databases, with a timeline established from 2009 to 2020. It was concluded that herbal medicines can be used as a safe therapeutic alternative in replacement of NSAIDs, as it offers a similar mechanism of action and reduced or even zero side effects. Thus, it can become a reality in dental practice by Dental Surgeons.

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Anti-Inflammatory Effect of Malva sylvestris, Sida cordifolia, and Pelargonium graveolens Is Related to Inhibition of Prostanoid Production

Cited by 38 publications

References 57 publications

Sida tuberculata extract reduces the nociceptive response by chemical noxious stimuli in mice: Implications for mechanism of action, relation to chemical composition and molecular docking

Sida tuberculata extract reduces the nociceptive response by chemical noxious stimuli in mice: Implications for mechanism of action, relation to chemical composition and molecular docking

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

Uso de medicamentos fitoterápicos como opção anti-inflamátoria na odontologia

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