Anti-inflammatory effect of naringin and sericin combination on human peripheral blood mononuclear cells (hPBMCs) from patient with psoriasis

Deenonpoe, Raksawan; Prayong, Pokpong; Thippamom, Nattakarn; Meephansan, Jitlada; Na‐Bangchang, Kesara

doi:10.1186/s12906-019-2535-3

Cited by 45 publications

(25 citation statements)

References 32 publications

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“…Naringin shows a productive anti-inflammatory activity, as reported in the present and previous studies [129][130][131]. This flavanone glycoside can also constrain the expression of the pro-inflammatory cytokines, including IL-1β and IL-6.…”

Section: Naringinsupporting

confidence: 87%

The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics

Abbasifard

Khorramdelazad

2020

Life Sciences

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Interleukin-6 (IL-6), known as an inflammatory cytokine, can be involved in many innate and adaptive immune responses. The role of IL-6 in the pathogenesis of the novel coronavirus disease 2019 (COVID-19) has recently received much more attention due to the spread of the virus and its pandemic potential. Cytokine storm is among the most critical pathological events in patients affected with coronaviruses (CoVs), i.e., severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and COVID-19, causing inflammation-induced lung injury and also occurring as a result of dysregulation of immune responses to the mentioned viruses. IL-6, along with some other inflammatory cytokines, including IL-1 beta (β), IL-8, and tumor necrosis factor-alpha (TNF-α), as well as inflammatory chemokines, can significantly contribute to, fever, lymphopenia, coagulation, lung injury, and multi-organ failure (MOF). Therefore, researchers are to explore novel approaches to treat the disease through targeting of IL-6 and its receptors based on prior experience of other disorders. In this review article, the latest findings on the role of IL-6 in the pathogenesis of COVID-19, as well as therapeutic perspectives, were summarized and discussed.

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Section: Naringinsupporting

confidence: 87%

The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics

Abbasifard

Khorramdelazad

2020

Life Sciences

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“…Naringin, a major flavanone of grapefruit and other citrus fruits, demonstrates several beneficial properties, including antioxidant and anticancer activities [ 152 , 153 , 154 , 155 ]. Naringin inhibited glucose metabolism in A375 melanoma cells in a concentration-dependent manner.…”

Section: Beneficial Effects Of Flavonoids In the Regulation Of Hypmentioning

confidence: 99%

Flavonoids Targeting HIF-1: Implications on Cancer Metabolism

Samec

Líšková

Koklesová

et al. 2021

Cancers

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Tumor hypoxia is described as an oxygen deprivation in malignant tissue. The hypoxic condition is a consequence of an imbalance between rapidly proliferating cells and a vascularization that leads to lower oxygen levels in tumors. Hypoxia-inducible factor 1 (HIF-1) is an essential transcription factor contributing to the regulation of hypoxia-associated genes. Some of these genes modulate molecular cascades associated with the Warburg effect and its accompanying pathways and, therefore, represent promising targets for cancer treatment. Current progress in the development of therapeutic approaches brings several promising inhibitors of HIF-1. Flavonoids, widely occurring in various plants, exert a broad spectrum of beneficial effects on human health, and are potentially powerful therapeutic tools against cancer. Recent evidences identified numerous natural flavonoids and their derivatives as inhibitors of HIF-1, associated with the regulation of critical glycolytic components in cancer cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), and pyruvate dehydrogenase kinase (PDK). Here, we discuss the results of most recent studies evaluating the impact of flavonoids on HIF-1 accompanied by the regulation of critical enzymes contributing to the Warburg phenotype. Besides, flavonoid effects on glucose metabolism via regulation of HIF-1 activity represent a promising avenue in cancer-related research. At the same time, only more-in depth investigations can further elucidate the mechanistic and clinical connections between HIF-1 and cancer metabolism.

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“… 30 , 31 Accumulating evidence suggests that naringin possesses a variety of pharmacological activities, including anti-osteoporotic, anti-cancer, anti-apoptotic, and anti-inflammatory effects, as well as effects on metabolic syndrome and central nervous system diseases, including neurological disorders. 32 , 33 , 34 Several reports have confirmed that naringin protects against steroid-induced ischemic necrosis by upregulating PPARγ, 35 and naringin can activate the 5’ adenosine monophosphate-activated protein kinase (AMPK) pathway to induce anti-inflammatory activity in sepsis. 36 Our previous studies have confirmed that naringin improves sepsis-induced intestinal injury through the regulation of the ROCK1/2 pathway, but the study of macrophage polarization by naringin has not yet been conducted.…”

Section: Introductionmentioning

confidence: 99%

Naringin improves sepsis-induced intestinal injury by modulating macrophage polarization via PPARγ/miR-21 axis

Yang

Gao

et al. 2021

Molecular Therapy - Nucleic Acids

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Naringin exhibited various pharmacological activities. However, its biological function and underlying mechanism in regulating macrophage polarization remain elusive. This study aimed to investigate the regulatory network between naringin and macrophage polarization in sepsis-induced intestinal injury. Cecal ligation and puncture (CLP) was used to establish the animal model of sepsis. Chromatin immunoprecipitation and a luciferase reporter assay were used to determine the interplay between peroxisome proliferator-activated receptor γ (PPARγ) and miR-21 promoter, as well as miR-21 and its target genes. Naringin enhanced the overall survival of septic mice and alleviated the CLP-induced inflammatory response and intestinal damage. This was accompanied by the increased expression of PPARγ in the intestines and the stimulation of ileal macrophages toward the M2 phenotype. Furthermore, in lipopolysaccharide-stimulated bone marrow-derived macrophages, naringin stimulated M2 polarization. Mechanistically, PPARγ inhibition attenuated the promotion of M2 polarization caused by naringin, and the naringin/PPARγ regulatory work was compromised by miR-21 inhibition. The present study suggested that naringin promoted M2 polarization via the PPARγ/miR-21 axis, thus relieving sepsis-induced intestinal injury. This study provides novel insights into the mechanism by which naringin alleviated sepsis-induced intestinal injury through regulation of macrophage polarization.

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Anti-inflammatory effect of naringin and sericin combination on human peripheral blood mononuclear cells (hPBMCs) from patient with psoriasis

Cited by 45 publications

References 32 publications

The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics

The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics

Flavonoids Targeting HIF-1: Implications on Cancer Metabolism

Naringin improves sepsis-induced intestinal injury by modulating macrophage polarization via PPARγ/miR-21 axis

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