Anti-Inflammatory Effect of Nigella Sativa Oil on Chemoradiation-Induced Oral Mucositis in Patients With Head and Neck Cancers

Ameen, H. A. M.; Mohammed, Mohammed Omer; Ahmed, Khadija; Ali, Rebaz Hama-Gareb; Saeed, Kamal Ahmed; Hussain, Saad Abdulrahman

doi:10.22159/ijcpr.2019v11i5.35704

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…In this trial, N. sativa oil mouthwash and Magic mouthwash were given to the research participants. Results of this trial indicated a significant reduction in the severity of oral mucositis after 3-4 weeks of radiotherapy 20 . Another clinical trial was conducted to treat oral mucositis in patients with acute myeloid leukemia (n=54) using N. sativa oil mouth rinse and magic mouthwash respectively.…”

Section: Table 1: Evaluation Of Pain/burning Sensation and Interincis...mentioning

confidence: 86%

Nigella sativa in Comparison to Steroids in Managing Oral Submucous Fibrosis

2022

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Background: Nigella sativa (N. sativa), a natural herb, commonly known as Black seed or Kalonji, has a prolonged medicinal history of more than 2000 years. Oral submucous fibrosis (OSMF) is a chronic inflammatory disorder, which is mostly treated with steroids. This clinical trial was conducted to assess the effectiveness of N. sativa oil in comparison to steroids for treating OSMF. Methods: This randomized clinical trial consisted of n=39 clinically diagnosed OSMF patients aged 18 years and above. Patients were divided through randomization into two groups. Group 1 was prescribed steroid lotion while Group 2 was given N. sativa oil (Cold-pressed) to be applied on the buccal mucosa for three months along with physiotherapy. Mann-Whitney U Test while the Wilcoxon Rank sum test were applied. A p-value of less than 0.05 was considered statistically significant. Results: Thirty patients (aged 35.33±2.07) completed the trial in which the majority were males (n=28, 93.30%) and were from Urdu-speaking communities [22 (73.30%)]. Most of the patients (n= 18, 60%) were consuming a combination of Pan and Areca Nut (Chaliya), 04 (13.3%) were consuming only areca nut while 03 (10%) used Gutkha as a habit. In this trial, N. sativa was found to be equally effective as compared to steroids in reducing pain and improving the interincisal mouth opening (IIMO) (p-value >0.05%). Conclusion: N. sativa can be used as an effective treatment option for reducing pain or burning and increasing interincisal mouth opening in patients with OSMF without producing any side effects. Keywords: Nigella sativa; Oral Submucous Fibrosis; Steroids; Head and Neck Squamous Cell Carcinoma.

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Section: Table 1: Evaluation Of Pain/burning Sensation and Interincis...mentioning

confidence: 86%

Nigella sativa in Comparison to Steroids in Managing Oral Submucous Fibrosis

2022

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“…Patients in Group A were asked to use NS oil mouthwash 5 times a day whereas participants in Group B were given Magic mouthwash and were instructed to use it in a similar manner. The results of this trial showed decrease in the severity of oral mucositis, which was assessed using the radiation therapy oncology group (RTOG) guidelines in chemotherapy or chemo-radiotherapy, treated HNSCC patients after using N. sativa oil mouthwash 28 .…”

Section: Nigella Sativa In Preventing Oral Mucositis In Head and Neck Squamous Cell Carcinoma (Hnscc)mentioning

confidence: 99%

Role of Nigella sativa Extract in Reducing the Inflammatory Damage in Oral Submucous Fibrosis – A Review

2021

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Nigella sativa (N. sativa) is an annual flowering plant, which belongs to the family Ranunculaceae. Both the seeds and oil of N. sativa have been researched extensively in the past few years due to the variety of its chemical ingredients and biological properties. N. sativa seeds contain many components including Thymoquinone (TQ), di-thymoquinone, fixed oils, alkaloids, flavonoids, proteins, fatty acids, saponins, and alpha-hederin. TQ is the most pharmacologically active component among all the constituents. The important properties exhibited by TQ are anti-inflammatory, anti-cancer, analgesic, anti-oxidant, anti-hypertensive and anti-diabetic activities. Oral submucous fibrosis (OSMF) is a chronic inflammatory disorder of the oral cavity, which has a multifactorial etiology. Areca nut consumption in the form of quid is considered as the most important factor in the development of the disease. It has a malignant transformation rate of 7-30%. A large number of researches have been conducted to investigate the outcome of using N. sativa and its active constituent TQ in various inflammatory conditions. This article is aimed at reviewing the literature available on various databases (Google Scholar, PubMed, and Online Journals) and to conclude if N. sativa can also be utilized as a potent anti-inflammatory agent for reducing the signs and symptoms of OSMF.

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