Anti-inflammatory Effect of Piperine in Adjuvant-Induced Arthritic Rats—a Biochemical Approach

Abstract

The present study was undertaken to investigate the anti-inflammatory effect of piperine against adjuvant-induced arthritis in rats, an experimental model for rheumatoid arthritis and compared it with that of the non-steroidal anti-inflammatory drug indomethacin. Administration of heat-killed Mycobacterium tuberculosis (0. 1 ml) intradermally into the right hind paw of rats resulted in increased paw volume, lysosomal enzymes, glycoproteins and tissue marker enzymes and decreased body weight. However, these changes were reverted to near normal levels upon piperine (30 mg/kg body weight, i.p.) treatment. Histopathological analysis of joints also revealed that synovial hyperplasia and mononuclear infiltration observed in arthritic rats were alleviated by piperine. Thus, the present study clearly indicated that piperine possesses promising anti-inflammatory effect against adjuvant-induced arthritis by suppressing inflammation and cartilage destruction.

Trikatu, a herbal compound mitigates the biochemical and immunological complications in adjuvant-induced arthritic rats

“…However, the boosting of antioxidant defence (enzymatic and non‐enzymatic) system by trikatu supplementation in arthritic rats might be primarily due to the free radical scavenging action of piperine, gingerol and shogaols. These findings are in line with the previous studies conducted in our laboratory . Moreover, the reports on the extracts of Zinger officinale and Piper nigrum on their antioxidant activity supports our claim …”

“…Trikatu is believed to promote health, immunity and longevity by strengthening all tissues of the body . In addition, our laboratory has also reported the anti‐arthritic property of trikatu and its active principles such as 6‐shogaol, 6‐gingerol and piperine on different experimental arthritic models . On the foreground of this, an attempt has been made to evaluate its anti‐arthritic effect with respect to various biochemical, immunological, histopathological and radiological parameters in aduvant‐induced arthritic rats.…”

Piperine inhibit inflammation, alveolar bone loss and collagen fibers breakdown in a rat periodontitis model

“…Similar to this study, Murunikkara et al . reported that the levels of inflammatory infiltration, lysosomal enzymes, lipid peroxidation and TNF‐α were reduced by a 30 mg/kg dose . In a rat arthritis model, piperine was administrated at 20 and 100 mg/kg doses, the results showed that 100 mg/kg piperine group exhibited a significant reduction in inflammatory cell number and paw volume .…”

Protection effect of piperine and piperlonguminine from Piper longum L. alkaloids against rotenone-induced neuronal injury

“…Thus, these two methods could be useful for the evaluation of drug-induced PD models. PIP and PLG both have been shown to confer resistance to oxidative stress (Chonpathompikunlert et al, 2011;Raj et al, 2011;Umar et al, 2013) and have anti-inflammatory (Murunikkara et al, 2012;Lee et al, 2013) and anti-cancer effects (Jarvius et al, 2013;Ouyang et al, 2013). Although the mechanistic bases of these effects are not fully understood, mitochondria could be a potential target.…”