Anti-inflammatory effect of resveratrol through the suppression of NF-&amp;kappa;B and JAK/STAT signaling pathways

Ma, Chunfang; Wang, Yin; Dong, Lei; Li, Minjing; Cai, Wanru

doi:10.1093/abbs/gmu135

Cited by 122 publications

(85 citation statements)

References 32 publications

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“…Therefore, STAT1 could contribute to iNOS upregulation in the diabetic lung [96,97]. The pro-inflammatory role of the JAK/STAT pathway is well established in the macrophage [98,99,100]. Antioxidants such as resveratrol have been reported to inhibit inflammatory pathways in mouse macrophages by inhibiting JAK/STAT signaling pathways, suggesting that DM-induced oxidative stress in the lung, contributing to DM-induced lung inflammation, could be mediated via JAK/STAT activation [98].…”

Section: Putative Signaling Mediating Diabetes-induced Microvasculmentioning

confidence: 99%

“…The pro-inflammatory role of the JAK/STAT pathway is well established in the macrophage [98,99,100]. Antioxidants such as resveratrol have been reported to inhibit inflammatory pathways in mouse macrophages by inhibiting JAK/STAT signaling pathways, suggesting that DM-induced oxidative stress in the lung, contributing to DM-induced lung inflammation, could be mediated via JAK/STAT activation [98]. A recent study reported that Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improved diabetic cardiomyopathy and cardiac fibrosis induced by streptozotocin in rats through inhibition of JAK2 and STAT3 phosphorylation [101].…”

Section: Putative Signaling Mediating Diabetes-induced Microvasculmentioning

confidence: 99%

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Diabetic Microvascular Disease and Pulmonary Fibrosis: The Contribution of Platelets and Systemic Inflammation

Jagadapillai

Rane

Lin

et al. 2016

IJMS

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Diabetes is strongly associated with systemic inflammation and oxidative stress, but its effect on pulmonary vascular disease and lung function has often been disregarded. Several studies identified restrictive lung disease and fibrotic changes in diabetic patients and in animal models of diabetes. While microvascular dysfunction is a well-known complication of diabetes, the mechanisms leading to diabetes-induced lung injury have largely been disregarded. We described the potential involvement of diabetes-induced platelet-endothelial interactions in perpetuating vascular inflammation and oxidative injury leading to fibrotic changes in the lung. Changes in nitric oxide synthase (NOS) activation and decreased NO bioavailability in the diabetic lung increase platelet activation and vascular injury and may account for platelet hyperreactivity reported in diabetic patients. Additionally, the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway has been reported to mediate pancreatic islet damage, and is implicated in the onset of diabetes, inflammation and vascular injury. Many growth factors and diabetes-induced agonists act via the JAK/STAT pathway. Other studies reported the contribution of the JAK/STAT pathway to the regulation of the pulmonary fibrotic process but the role of this pathway in the development of diabetic lung fibrosis has not been considered. These observations may open new therapeutic perspectives for modulating multiple pathways to mitigate diabetes onset or its pulmonary consequences.

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Section: Putative Signaling Mediating Diabetes-induced Microvasculmentioning

confidence: 99%

Section: Putative Signaling Mediating Diabetes-induced Microvasculmentioning

confidence: 99%

Diabetic Microvascular Disease and Pulmonary Fibrosis: The Contribution of Platelets and Systemic Inflammation

Jagadapillai

Rane

Lin

et al. 2016

IJMS

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“…In murine RAW 264.7 macrophages and microglial BV-2 cells, resveratrol also inhibited microglial activation by suppressing the NF-κB pathway [54]. In another study, resveratrol showed anti-inflammatory effect by suppressing the NF-κB pathway in RAW 264.7 murine macrophages in a dose-dependent manner [55]. These studies suggest that resveratrol has anti-inflammatory, antioxidant, anti-carcinogenic effects and can strengthen hemodynamic structure, which in turn can positively affect the aging process and longevity.…”

Section: Gene Expression and Regulation In Mammalian Cells -Transcripmentioning

confidence: 93%

Stress Response of Dietary Phytochemicals in a Hormetic Manner for Health and Longevity

Gezer¹

2018

Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics

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The stress responses observed in mammalian cells can be classified as heat shock response, unfolded protein response, autophagic response, deoxyribonucleic acid damage response, antioxidant response, and sirtuin response at the intracellular and molecular levels. Factors that strengthen the hemodynamic structure causing low-level molecular damage and activating one or several stress response pathways are called hormetins. Hormetins can be categorized as physical, physiological, biological, and nutritional hormetins. Nutritional hormetins provide an interesting, comprehensive research topic because of their effects on health and lifespan. Dietary phytochemicals, with their low-level stress-inducing effects, are potential nutritional hormetins. Resveratrol, curcumin, epicatechin, isothiocyanates, ferulic acid, and certain vitamin-minerals can induce a heat shock response, unfolded protein response, autophagic response, deoxyribonucleic acid damage response, antioxidant response, and sirtuin response causing the stimulation of kinases and transcription factors. Studies have shown that these phytochemicals are related to nuclear factor-erythroid 2, sirtuins, nuclear factor-kappa B, and heat shock response pathways. In this chapter, the stress response of dietary phytochemicals will be systematically examined in a hormetic manner for delay of age-related diseases, healthy aging, and longevity based on current data.

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“…Resveratrol also inhibited HMGB1 release in other systems possibly via suppressing the JAK/STAT1 signaling pathway [150,151], which is important in mediating HMGB1 hyperacetylation and translocation [152]. Sirtuin-1 was recently identified as a novel mediator of deacetylation of HMGB1 [153].…”

Section: Active Compounds From Chinese Herbal Medicine For Targeting mentioning

confidence: 99%

Targeting ONOO<sup>-</sup>/HMGB1/MMP-9 Signaling Cascades: Potential for Drug Development from Chinese Medicine to Attenuate Ischemic Brain Injury and Hemorrhagic Transformation Induced by Thrombolytic Treatment

Chen¹,

Guan²,

Shen³

2016

Integr Med Int

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Stroke is the leading cause of death and disability worldwide, and ischemic stroke accounts for more than 85% of the stroke incidence. Tissue plasminogen activator (t-PA) is the only FDA-approved drug for ischemic stroke treatment with a narrow treatment time window of 4.5 h. Hemorrhagic transformation (HT) is a severe complication of delayed t-PA treatment in ischemic stroke. Thus, it is critically important to develop combination therapies to reduce HT and extend the therapeutic time window of t-PA. Current progress suggests that peroxynitrite (ONOO^-)/high-mobility group box 1 protein (HMGB1)/matrix metalloproteinase-9 (MMP-9) signaling cascades could be important for attenuating HT during thrombolytic treatment for acute ischemic stroke. Recently, important progress has been made in seeking for natural compounds from Chinese medicine for reducing ischemic stroke injury, with some of them targeting ONOO^-/HMGB1/MMP-9 signaling cascades. Herein, we analyze the roles and interactions of these three targets in mediating HT; subsequently, we summarize the potential compounds from Chinese herbal medicine for attenuating HT and analyze the related targets. Finally, we raise the potential issues to be addressed in further development of these compounds as combination therapy.

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Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signaling pathways

Cited by 122 publications

References 32 publications

Diabetic Microvascular Disease and Pulmonary Fibrosis: The Contribution of Platelets and Systemic Inflammation

Diabetic Microvascular Disease and Pulmonary Fibrosis: The Contribution of Platelets and Systemic Inflammation

Stress Response of Dietary Phytochemicals in a Hormetic Manner for Health and Longevity

Targeting ONOO<sup>-</sup>/HMGB1/MMP-9 Signaling Cascades: Potential for Drug Development from Chinese Medicine to Attenuate Ischemic Brain Injury and Hemorrhagic Transformation Induced by Thrombolytic Treatment

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