Anti-inflammatory effect of roasted licorice extracts on lipopolysaccharide-induced inflammatory responses in murine macrophages

Kim, Jin‐Kyung; Oh, Sun-mee; Kwon, Hyuck-Se; Oh, Yang-Seok; Lim, Soon Sung; Shin, Hyun‐Kyung

doi:10.1016/j.bbrc.2006.05.035

Cited by 127 publications

(86 citation statements)

References 45 publications

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“…The spleen is the principal site of adaptive immune responses to blood-borne antigens, owing to an abundance of resident phagocytes and lymphocytes. Spleen cells are stimulated with CII and concanavalin A to activate T cells or LPS to potently activate macrophages (45). The spleens from the vehicle-treated CIA mice in our study were substantially enlarged as compared to those from the controls (data not shown), as evidence that CII augmented immune responses in the CIA mice.…”

Section: Discussionmentioning

confidence: 51%

Honokiol Inhibits the Progression of Collagen-Induced Arthritis by Reducing Levels of Pro-inflammatory Cytokines and Matrix Metalloproteinases and Blocking Oxidative Tissue Damage

et al. 2010

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Abstract. Plant-derived compounds with potent anti-inflammatory activity have attracted a great deal of attention as a source for novel anti-arthritic agents with minimal side effects. We attempted to determine the anti-arthritic effects of orally administered honokiol isolated from Magnolia species. The oral administration of honokiol inhibited the progression and severity of type II collagen (CII)-induced arthritis (CIA) by reducing clinical arthritis scores and paw swelling. The histological analysis demonstrated preserved joint space; and the immunohistochemical data showed that the levels of interleukin (IL)-17, matrix metalloproteinase (MMP)-3, MMP-9, MMP-13, and receptor activator for nuclear factor-κB ligand, as well as nitrotyrosine formation, were substantially suppressed in the honokiol-treated CIA mice. The elevated serum levels of tumor necrosis factor-α and IL-1β in the CIA mice were also restored to control levels via honokiol treatment. In the CIA mice, honokiol inhibited CII-or lipopolysaccharide-stimulated cytokine secretion in spleen cells, as well as CII-stimulated spleen cell proliferation. Furthermore, honokiol treatment reduced CIAinduced oxidative damage in the liver and kidney tissues of CIA mice. Collectively, the oral administration of honokiol inhibited CIA development by reducing the production of pro-inflammatory cytokines, MMP expressions, and oxidative stress. Thus, honokiol is an attractive candidate for an anti-arthritic agent.Keywords: type II collagen-induced arthritis, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), matrix metalloproteinase (MMP), oxidative damage Full Paper

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Section: Discussionmentioning

confidence: 51%

Honokiol Inhibits the Progression of Collagen-Induced Arthritis by Reducing Levels of Pro-inflammatory Cytokines and Matrix Metalloproteinases and Blocking Oxidative Tissue Damage

et al. 2010

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“…koreana, C. saxicola, S. adoxoides, T. officinale, C. coronarium, G. inflate, and L. japonica are commonly employed ethnopharmacological agents used for the treatment of inflammatory diseases in China (Aly, Al-Alousi and Salem, 2005, Bor, Chen and Yen, 2006, Cheng, Li, You and Hu, 2005, Hu and Kitts, 2005, Jung, Richter, Kabrodt, Lucke, Schellenberg and Herrling, 2006, Kang, Yoon, Cho, Han, Lee, Park and Kim, 2005, Kim, Min, Jeong, Lee, Lee and Seo, 2005, Kim, Kim, Baek, Lee, Kim, Kwon and Lee, 2006, Kim, Oh, Kwon, Oh, Lim and Shin, 2006, Ko, Wei and Chiou, 2006, Leu, Wang, Huang and Shi, 2005, Leung, Kuo, Yang, Lin and Lee, 2006, Li, Yuan, Xiong, Lu, Qin, Chen and Liu, 2006, Li, Zhang, Zhang, Liu, Wang, Wang, Zhu and Chen, 2006, Ling, Wu and Li, 2006, Makino, Tsubouchi, Murakami, Haneda and Yoshino, 2006, Niu, Chang, Jiang, Cui, Chen, Yuan and Tu, 2006, Niu, Cui, Li, Chang, Jiang, Qiao and Tu, 2006, Rusu, Tamas, Puica, Roman and Sabadas, 2005, Seo, Koo, An, Kwon, Lim, Seo, Ryu, Moon, Kim, Kim and Hong, 2005, Son, Moon, Lee, Son, Kim, Kang, Son, Lee and Chang, 2006, Strzelecka, Bzowska, Koziel, Szuba, Dubiel, Riviera Nunez, Heinrich and Bereta, 2005, Su, 2004, Suh, Chung, Son, Kim, Moon, Son, Kim, Chang and Kim, 2006, Thanabhorn, Jaijoy, Thamaree, Ingkaninan and Panthong, 2006, Zhan and Yang, 2006. F. koreana, used as a single-agent antimicrobial, antiinflammatory, and diuretic, contains the cyclohexylethanoid compound rengyolone, found to be a potent inhibitor of NO and tissue necrosis factor-α (TNF-α) in vitro; this compound inhibits inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) expression in macrophages in response to lipopolysaccharide (LPS) stimulation …”

Section: Discussionmentioning

confidence: 99%

“…C. coronarium has proven protective against the development of CCl 4 -induced liver injury in rats and decreases delayed-type hypersensitivity in mice, as well as inhibiting iNOS expression and NO production from RAW264.7 cells in vitro (Bor, Chen andYen, 2006, Rusu, Tamas, Puica, Roman andSabadas, 2005). G. inflate, also known as licorice, inhibits the production of NO and prostaglandin E 2 (PGE 2 ) from RAW264.7 cells in response to LPS stimulation, likely through inhibition of nuclear factor KB (NF-KB), and confers a survival advantage and decreases cytokine expression in murine LPS-induced septic shock (Aly, Al-Alousi and Salem, 2005, Kang, Yoon, Cho, Han, Lee, Park and Kim, 2005, Kim, Oh, Kwon, Oh, Lim and Shin, 2006, Makino, Tsubouchi, Murakami, Haneda and Yoshino, 2006. Ochnaflavone, a biflavonoid, has been isolated from L. japonica; in vitro, this compound inhibits phosphorylation of ERK1/2 and p38 mitogenactivated protein kinase (MAPK) and inhibits NF-KB activity in RAW264.7 cells, leading to decreased iNOS expression and NO formation in response to LPS (Suh, Chung, Son, Kim, Moon, Son, Kim, Chang and Kim, 2006).…”

Section: Discussionmentioning

confidence: 99%

Alternative Medicine Products as a Novel Treatment Strategy for Inflammatory Bowel Disease

et al. 2008

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Inflammatory bowel disease (IBD) affects the mucosal lining of the gastrointestinal tract; the etiology is unknown and treatment is directed at systemic immunosuppression. Natural products, including medicinal herbs, have provided approximately half of the drugs developed for clinical use over the past 20 years. The purpose of our current study was to determine the effects of a novel combination of herbal extracts on intestinal inflammation using a murine model of IBD. Female Swiss-Webster mice were randomized to receive normal water or 5% dextran sulfate sodium (DSS) drinking water to induce colitis. Mice were treated with either a novel combination of herbal aqueous extracts or vehicle control per os (po) or per rectum (pr) every 24h for 7-8d. Disease activity index score (DAI) was determined daily; mice were sacrificed and colons analyzed by H&E staining, MPO assay, and cytokine (TNF-α, IL-6) ELISAs. Mice treated with the combination of herbal extracts, either po or pr, had significantly less rectal bleeding and lower DAI scores when compared to the vehicle-treated group. Moreover, colonic ulceration, leukocytic infiltration, and cytokine levels (TNF-α and IL-6) were decreased in the colons of herbal-treated mice, reflected by H&E staining, MPO assay, and cytokine ELISA. Treatment with the combination of medicinal herbs decreases leukocyte infiltration and mucosal ulceration, ameliorating the course of acute colonic inflammation. This herbal remedy may prove to be a novel and safe therapeutic alternative in the treatment of IBD.

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“…It is also a protective attempt to remove the injurious stimuli and initiate the healing process of the tissue. In these cases, macrophages play a key role in inflammation (Kim et al 2006). Anti-inflammatory agents can be used to treat inflammatory reactions and most of these agents act by preventing the release of inflammatory mediators or inhibiting the action of released mediators on their target cells.…”

Section: Cell Culturementioning

confidence: 99%

5β-Hydroxypalisadin B isolated from red alga Laurencia snackeyi attenuates inflammatory response in lipopolysaccharide-stimulated RAW 264.7 macrophages

Wijesinghe¹,

Kang²,

Lee³

et al. 2014

ALGAE

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In this study, four compounds isolated from the red alga Laurencia snackeyi were evaluated for their potential antiinflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. These compounds were tested for their inhibitory effects on nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. Since 5β-hydroxypalisadin B showed the best activity it was further tested for the production of prostaglandin-E 2 (PGE 2 ), expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), the release of pro-inflammatory cytokines tumor necrotic factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). 5β-Hydroxypalisadin B significantly reduced the PGE 2 release and suppressed the iNOS and COX-2 expression in LPS-stimulated RAW 264.7 cells. It also significantly reduced the release of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6. These findings provide the first evidence of antiinflammatory potential of 5β-hydroxypalisadin B isolated from the red alga L. snackeyi and hence, it could be exploited as an active ingredient in pharmaceutical, nutraceutical and functional food applications.

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Anti-inflammatory effect of roasted licorice extracts on lipopolysaccharide-induced inflammatory responses in murine macrophages

Cited by 127 publications

References 45 publications

Honokiol Inhibits the Progression of Collagen-Induced Arthritis by Reducing Levels of Pro-inflammatory Cytokines and Matrix Metalloproteinases and Blocking Oxidative Tissue Damage

Honokiol Inhibits the Progression of Collagen-Induced Arthritis by Reducing Levels of Pro-inflammatory Cytokines and Matrix Metalloproteinases and Blocking Oxidative Tissue Damage

Alternative Medicine Products as a Novel Treatment Strategy for Inflammatory Bowel Disease

5β-Hydroxypalisadin B isolated from red alga Laurencia snackeyi attenuates inflammatory response in lipopolysaccharide-stimulated RAW 264.7 macrophages

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