Anti-inflammatory effect of the aqueous extract from Lonicera japonica flower is related to inhibition of NF-kappaB activation through reducing I-kappaBalpha degradation in rat liver.

Lee, J H; Ko, Woo Shin; Kim, Y H; Kang, Hye-Joo; Kim, H D; Choi, Byung Tae

doi:10.3892/ijmm.7.1.79

Cited by 29 publications

(23 citation statements)

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“…[14][15][16][17] Traditional claims and pharmacological studies have indicated that LJ may be an attractive candidate for the treatment of various CNS disorders and neurodegenerative diseases. Recently, ethanolic extracts of LJ were shown to inhibit aggregation and neurotoxicity of amyloid beta (Ab ) in human neuroblastoma cells.…”

Section: Introduction Mmentioning

confidence: 99%

Lonicera japonicaTHUNB. Extract Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses by Suppressing NF-κB Signaling in BV-2 Microglial Cells

Kwon

Hong

et al. 2015

Journal of Medicinal Food

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In the current study, we evaluated the anti-inflammatory effects of Lonicera japonica THUNB. (LJ) and its underlying molecular mechanism in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Our results indicated that LJ significantly inhibits LPS-stimulated production of nitric oxide (NO) and prostaglandin E2 (PGE2). In addition, LJ inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at both the protein and mRNA levels. In LPSstimulated BV-2 microglial cells, LJ inhibited proinflammatory cytokines and chemokines, tumor necrosis factor-a (TNF-a), interleukin-1b (IL-1b), monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9) enzymatic activities, and/or mRNA expression, as well as reactive oxygen species (ROS) production. LJ significantly suppressed activation of nuclear factor-jB (NF-jB) and its translocation from the cytosol to the nucleus and suppressed the DNA-binding activity of NF-jB. Furthermore, LJ significantly inhibited phosphorylation of c-Jun N-terminal kinase ( JNK), extracellular signalregulated kinase 1/2 (ERK 1/2), p38 mitogen-activated protein kinases (MAPKs), phosphatidylinositol 3-kinases (PI3K)/Akt, and Janus kinase 1 ( JAK1)/signal transducer and activator of transcription (STAT)1/3. Collectively, our findings indicated that the antineuroinflammatory properties of LJ in LPS-induced BV-2 microglial cells is due to downregulation of proinflammatory cytokines and chemokines downstream of inhibition of NF-jB activation.

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Section: Introduction Mmentioning

confidence: 99%

Lonicera japonicaTHUNB. Extract Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses by Suppressing NF-κB Signaling in BV-2 Microglial Cells

Kwon

Hong

et al. 2015

Journal of Medicinal Food

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“…One of these, chlorogenic acid, was found to be able to activate macrophages through the calcineurin pathway in a human cell line ). The extract of this plant is known to be an anti-inflammatory agent and is used widely to treat upper respiratory tract infections, diabetes mellitus and rheumatoid arthritis (Lee et al 2001). Nile tilapia treated with Lonicera extract showed significantly enhanced phagocytic and respiratory bursts of activity of blood phagocytic cells and a lower mortality than untreated fish (Ardó et al 2008).…”

Section: Lonicera Japonicamentioning

confidence: 98%

The use of immunostimulating herbs in fish. An overview of research

Jeney

Yin

Ardó

et al. 2009

Fish Physiol Biochem

212

109

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The use of immunostimulants as an alternative to the drugs, chemicals and antibiotics currently being used to control fish diseases in fish culture is attracting the attention of many researchers. In this context, many have focused on the use of medicinal plant products as potential therapeutic measures for modulating the immune response and, specifically, on the use of herbs to prevent and control fish diseases. Medicinal plants (plant remedies) are a deeply rooted component of the cultural heritage of many people from diverse cultures and countries and are, as such, closely linked to the maintenance of good health. The aim of this paper is to review research currently being carried out on the herbs and herbal extracts that have been shown to modulate the immune system of fish. Special attention is given to the use of Chinese and Indian herbs.

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“…The main components of L. japonica Thunb. include chlorogenic acid (CGA), iso-chlorogenic acid, luteolin, caffeic acid, and volatile oil (Machida et al, 2002), of which CGA and iso-chlorogenic acid are the main antibacterial ingredients (Lee et al, 2001). CGA is a secondary metabolite and its concentration varies dramatically among different tissues and flowering stages of the L. japonica Thunb.…”

Section: Introductionmentioning

confidence: 99%

Cloning and expression analysis of the Lonicera japonica Thunb. chlorogenic acid synthetase gene (LjCCoAOMT1) in rice

Jiang¹,

Cw²,

Zhu³

et al. 2014

Genet. Mol. Res.

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ABSTRACT.Complete coding DNA sequences of a closely related chlorogenic acid synthetase gene (LjCCoAOMT1) were isolated from Lonicera japonica Thunb. by reverse transcription polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends (RACE). LjCCoAOMT1 was subsequently overexpressed in Escherichia coli and a 25-kD protein was detected by electrophoresis and western blot analysis. High-performance liquid chromatography (HPLC) analysis showed that recombinant LjCCoAOMT1 methylates the caffeic acid substrate to generate ferulic acid. Further analysis showed that the chlorogenic acid content was significantly correlated with the expression level of LjCCoAOMT1 in various tissues of L. japonica Thunb. at different developmental stages. A plant expression vector containing LjCCoAOMT1 was constructed and Agrobacterium-mediated transgenic rice was successfully obtained. Light treatment analysis showed that LjCCoAOMT1 transgenic rice was more sensitive than wild-type rice in responding to the changes in lighting conditions. Although gibberellic acid (GA3) could promote the growth of both wild-type and 2167 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (1): 2166-2176 (2014 Cloning, functional analysis, and expression of LjCCoAOMT1 in rice LjCCoAOMT1 transgenic rice, LjCCoAOMT1 transgenic rice appeared to be more sensitive to GA3. Furthermore, high concentrations of GA3 significantly facilitated the growth of LjCCoAOMT1 transgenic rice.

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Anti-inflammatory effect of the aqueous extract from Lonicera japonica flower is related to inhibition of NF-kappaB activation through reducing I-kappaBalpha degradation in rat liver.

Cited by 29 publications

References 0 publications

Lonicera japonicaTHUNB. Extract Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses by Suppressing NF-κB Signaling in BV-2 Microglial Cells

Lonicera japonicaTHUNB. Extract Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses by Suppressing NF-κB Signaling in BV-2 Microglial Cells

The use of immunostimulating herbs in fish. An overview of research

Cloning and expression analysis of the Lonicera japonica Thunb. chlorogenic acid synthetase gene (LjCCoAOMT1) in rice

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