Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice

Melo, Caroline Mourão; Morais, Talita Cavalcante; Tomé, Adriana R.; Brito, Gerly Anne Castro; Chaves, Mariana Helena; Rao, V. S. N.; Santos, Flávia Almeida

doi:10.1007/s00011-011-0321-x

Cited by 65 publications

(38 citation statements)

References 47 publications

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“…Pharmacokinetic investigations with a reliable GC-MS method reveal that amyrin has low bioavailabilty but a long elimination half life, following its oral administration to normal rats [35]. However, earlier works [9-16] show that it is orally effective in several animal models of inflammation, nociception, gastroprotection and hepatoprotection. Also, the present study demonstrates the oral efficacy of alpha, beta-amyrin in reducing hyperglycemia and hyperlipidemia in the experimental models of STZ-induced diabetes and diet induced hyperlipidemia.…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study, we demonstrated the anti-inflammatory and antioxidant effects of α, β-Amyrin in rodent models of cerulein-induced acute pancreatitis and ligature-induced acute periodontitis [9,10], wherein this triterpenoid was found to significantly inhibit the serum level of pro-inflammatory cytokine TNF- α as well as the increases in myeloperoxidase (MPO) activity and and thiobarbituric acid-reactive substances (TBARS). In the present study, treatment with α, β-amyrin effectively restored the reduced insulin levels seen in streptozotocin-diabetic controls.…”

Section: Discussionmentioning

confidence: 99%

“…March (Burseraceae) is a reputed folk medicinal agent because of its analgesic and anti-inflammatory properties [8]. Chemical investigations have revealed the presence of α, β-amyrin, a pentacyclic triterpene as the major component of resin, and pharmacological studies have revealed anti-inflammatory and antinociceptive, antioxidant, antipruritic, gastroprotective and hepatoprotective effects, at non-toxic doses, which range from 10 to 100 mg/kg [9-16]. The pentacyclic triterpene α, β-amyrin (Figure 1) is constituted of triterpenes, that belongs to the group of ursane and oleanane series and that this class of agents has the chemical structure similar to that of a steroid and are extremely useful in prevention or treatment of many diseases in experimental animals, particularly those in which oxidative and inflammatory stress plays a key role in pathogenesis [17].…”

Section: Introductionmentioning

confidence: 99%

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Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice

et al. 2012

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BackgroundPentacyclic triterpenes in general exert beneficial effects in metabolic disorders. This study investigated the effects of α, β-amyrin, a pentacyclic triterpene mixture from the resin of Protium heptaphyllum on blood sugar level and lipid profile in normal and streptozotocin (STZ)-induced diabetic mice, and in mice fed on a high-fat diet (HFD).FindingsMice treated with α, β-amyrin (10, 30 and 100 mg/kg, p.o.) or glibenclamide (10 mg/kg, p.o.) had significantly reduced STZ-induced increases in blood glucose (BG), total cholesterol (TC) and serum triglycerides (TGs). Unlike glibenclamide that showed significant reductions in BG, TC and TGs in normoglycemic mice, α, β-amyrin did not lower normal blood sugar levels but at 100 mg/kg, manifested a hypolipidemic effect. Also, α, β-amyrin effectively reduced the elevated plasma glucose levels during the oral glucose tolerance test. Moreover, the plasma insulin level and histopathological analysis of pancreas revealed the beneficial effect of α, β-amyrin in the preservation of beta cell integrity. In mice treated orally with α, β-amyrin (10, 30 and 100 mg/kg) or fenofibrate (200 mg/kg), the HFD-associated rise in serum TC and TGs were significantly less. The hypocholesterolemic effect of α, β-amyrin appeared more prominent at 100 mg/kg with significant decreases in VLDL and LDL cholesterol and an elevation of HDL cholesterol. Besides, the atherogenic index was significantly reduced by α, β-amyrin.ConclusionsThese findings reflect the potential antihyperglycemic and hypolipidemic effects of α, β-amyrin mixture and suggest that it could be a lead compound for drug development effective in diabetes and atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice

et al. 2012

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“…These triterpenes have been reported to exert anti-inflammatory properties in various animal models, including colitis, cystitis or pancreatitis. [7][8][9] In the central nervous system, α-and β-amyrin have been reported to exhibit anti-nociceptive properties via the activation of cannabinoid receptors 10,11) and to exhibit antianxiety or anti-depression properties through the modulation of the benzodiazepine site of the γ-aminobutyric acid type A (GABA A ) receptor or noradrenergic receptor, respectively.…”

mentioning

confidence: 99%

Amyrin Attenuates Scopolamine-Induced Cognitive Impairment in Mice

Park

Ahn

et al. 2014

Biological & Pharmaceutical Bulletin

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Alzheimer's disease, a neurodegenerative disorder, is characterized by progressive cognitive impairment associated with the disruption of cholinergic neurotransmission. The aim of the present study was to evaluate the effect of α-or β-amyrin, a type of pentacyclic triterpene, on the cognitive impairment induced by scopolamine, a muscarinic acetylcholine receptor antagonist. To measure the abilities of various types of learning and memory, we conducted step-through passive avoidance task. Scopolamine induced deficits in learning and memory processes in mice, which were antagonized by a single administration of α-amyrin (2 or 4 mg/kg) or β-amyrin (4 mg/kg), respectively. Additionally, in vitro analysis revealed that acetylcholinesterase activity was inhibited by β-amyrin, but not by α-amyrin. Furthermore, Western blot analysis revealed that the expression levels of phosphorylated extracellular signal-regulated kinase 1/2 (pERK) and phosphorylated glycogen synthase kinase-3β (pGSK-3β) were significantly enhanced by a single administration of α-and β-amyrin in the hippocampus. Finally, the memory ameliorating effects of α-or β-amyrin on the scopolamine-induced cognitive impairments were significantly blocked by ERK inhibitor U0126. The present study suggests that α-and β-amyrin may ameliorate the cognitive impairment induced by hypocholinergic neurotransmission via the activation of ERK as well as GSK-3β signaling.

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“…It was also demonstrated that the lethal dose of geniposide was 1431.1 mg/kg (Ding et al 2013). In pancreatitis, they greatly suppressed inflammatory cell infiltration, acinar cell necrosis, the expression of TNF-α and the inducible nitric oxide synthase, decreases the serum levels of amylase and lipase and of interleukin IL-6 and the activity of pancreatic mieloperoxidase (MPO) (Melo et al 2010(Melo et al , 2011.…”

Section: Genipa Americana Lmentioning

confidence: 99%

Chemistry and pharmacology of some plants mentioned in the letter of Pero Vaz de Caminha

Alves¹,

Ming²

2015

Ethnobio Conserv

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Brazil has a long tradition in the study of medicinal plants. When the Portuguese arrived to the new colony, Pero Vaz de Caminha, the scriber of the fleet, left the first impressions of the local and the inhabitants. He clearly mentions how the Indians use natural dye as tincture to paint their bodies. This article reviews the phytochemical and pharmacological characteristics of these colorants and other medicinal plants recently identified mentioned in this letter.

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Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice

Abstract: α,β-Amyrin ameliorates cerulein-induced acute pancreatitis by acting as an anti-inflammatory and antioxidant agent.

Cited by 65 publications

References 47 publications

Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice

Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice

Amyrin Attenuates Scopolamine-Induced Cognitive Impairment in Mice

Chemistry and pharmacology of some plants mentioned in the letter of Pero Vaz de Caminha

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