Anti-inflammatory effects of 6S-5-methyltetrahydrofolate‐calcium on RAW264.7 cells and zebrafish

Bin, Xinni; Gao, Ying-Bin; Miao, Ping; Lian, Zenglin; Cheng, Yongzhi; Wu, Jiaqi; He, Ming-Fang

doi:10.1016/j.lfs.2023.121839

Cited by 2 publications

(1 citation statement)

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“…5-Methyltetrahydrofolate (5-MTHF) (Figure ), as a member of the folic acid (FA) family, can be used as a food additive and a main ingredient in nutritional supplements as well as a drug to prevent or treat psoriasis, rheumatoid arthritis, megaloblastic anemia, and cancer . Therefore, 5-MTHF has become a common focus of attention in the food and biomedical fields because of its remarkable efficacy and low side effects. − In view of this, the efficient synthesis of 5-MTHF has always been the primary task. Though many efforts have been made, the synthesis of 5-MTHF with FA as the starting material has been found to be the only reliable route in industry because folic acid is easily obtainable commercially at economically convenient prices …”

Section: Introductionmentioning

confidence: 99%

Continuous Flow Synthesis of 5-Methyltetrahydrofolate from Folic Acid

Zhang,

Xiao,

Feng

et al. 2024

Org. Process Res. Dev.

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5-Methyltetrahydrofolate (5-MTHF) is an active form of folic acid (FA) and an essential micronutrient preventing anemia and numerous other adverse health conditions such as cardiovascular disease and cancer. Herein, a continuous flow sequence synthesis of 5-MTHF from FA was developed, involving three elementary steps: catalytic hydrogenation of FA to tetrahydrofolic acid (THFA), methylenation of THFA with formaldehyde, and hydrogenation of the methylenation intermediates to 5-MTHF. This process features an expeditious synthesis of 5-MTHF in an integrated flow platform with water as the sole solvent and without any intermediate purification. The overall yield of this three-step flow process was up to 53.54% in a total residence time of 71.4 min. The separated yield of 5-MTHF reached 49.3%.

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