Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillusL.) on croton oil-induced ear edema andPropionibacterium acnesplus LPS-induced liver damage in mice

Abstract

Bilberry (Vaccinium myrtillus L.) has been known to play a protective role in human health due to its high anthocyanin content. This study investigated the anti-inflammatory effects of bilberry extract (BE, containing 42.04% anthocyanin) on Propionibacterium acnes (P. acnes) plus lipopolysaccharide (LPS) induced liver injury and croton oil-induced ear edema in mice. Results showed that BE could effectively inhibit croton oil-induced ear edema and liver inflammation provoked by P. acnes plus LPS, as reflected by the reduced plasma alanine aminotransferase and aspartate aminotransferase activities. These findings were confirmed by hepatic pathological examination. Moreover, BE administration markedly suppressed the increase of liver mRNA levels of iNOS, TNF-α, IL-1β and IL-6, and the protein levels of iNOS, TNF-α and NF-κB. In addition, liver malondialdehyde and NO contents were significantly reduced by BE treatment. These results indicated that BE has potent protective effects on acute and immunological inflammation, which might contribute to the study of the anti-inflammatory effects of natural products and healthy food.

Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination

“…However, it should be kept in mind that the treatment with ANT reduced the NOx levels in the EB groups (Fig. 2C), and this appears to agree with the studies that showed berry ANT suppressed the expression iNOS, TNF-α, IL6 and IL-1β in the liver [111,112] and the secretion of proinflammatory mediators by the macrophage inhibition of NF-kappaB [113].…”

Variations in the carotenoid and anthocyanin contents of Korean cultural varieties and home-processed sweet potatoes

“…These compounds play a 32 role in attracting animals in pollination and seed dispersal; they 33 may also enhance plant resistance to insect attack, act as 34 endogenous plant antioxidants and photoprotectors (Strack and 35 Wray, 1993;Delgado-Vargas et al, 2000). Evidence also suggests 36 that this group of phytochemicals, besides being nontoxic and 37 non-mutagenic, could exhibit multiple biological effects, such as 38 antioxidant activity, anti-inflammatory action, inhibition of blood 39 platelet aggregation, and antimicrobial activity, and could be used 40 in the treatment of diabetic retinopathy and prevention of 41 cholesterol-induced atherosclerosis (Luo et al, 2014;Pascual-42 Teresa et al, 2013;Zheng and Wang, 2003). 43 Sweet potato is the root of Ipomoea batatas (L.) Lam.…”

A 12-Week-Long Intake of Bilberry Extract (Vaccinium myrtillus L.) Improved Objective Findings of Ciliary Muscle Contraction of the Eye: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Trial

“…Anthocyanin in bilberry extract is a highly soluble antioxidant with a flavylium ion structure [21]. It is found in the ocular tissues [22] and suppresses various inflammatory factors in the body [23]. Because it is possible that anthocyanins migrate and are distributed from the blood to the ciliary muscle, they can suppress and relieve the tension in the ciliary muscle, thereby potentially reducing ocular fatigue.…”