Anti-inflammatory effects of banana (Musa balbisiana) peel extract on acne vulgaris: In vivo and in silico study

Savitri, Dwiana; Wahyuni, Sitti; Bukhari, Agussalim; Djawad, Khairuddin; Hatta, Mochammad; Riyanto, Puguh; Bahar, Burhanuddin; Wahab, Siswanto; Hamid, Firdaus; Rifai, Yusnita

doi:10.1016/j.jtumed.2023.07.008

Cited by 5 publications

(4 citation statements)

References 60 publications

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“…Moreover, approximately 40% of patients with acne experience long-term issues such as scarring and excessive pigmentation [19]. The pathophysiological factors of acne include changes in sebum production, excessive keratinization, inflammatory processes, and the proliferation of commensal bacterium C. acnes on the skin [20]. C. acnes constitutes one of the most prevalent skin microbiotas and plays a crucial role in the maintenance of a resilient and healthy skin barrier [21].…”

Section: Discussionmentioning

confidence: 99%

Peiminine Exerts Its Anti-Acne Effects by Regulating the NF-κB Pathway

Cha,

Kim,

Shin

et al. 2024

Antioxidants

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Peiminine is the main natural alkaloid compound extracted from the Chinese herb Fritillaria. Although peiminine is known for its antioxidant and anti-inflammatory effects in conditions such as mastitis and arthritis, its impact on inflammation induced by Cutibacterisum acnes (C. acnes) has not been explored. The aim of this study was to investigate the effect of peiminine on C. acnes-induced inflammatory responses in the skin and to identify the underlying mechanism involved. We discovered that peiminine inhibits the C. acnes-induced expression of inflammatory mediators such as pro-interleukin-1β (pro-IL-1β), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in mouse bone marrow-derived macrophages (BMDMs). Peiminine suppressed the activation of nuclear factor-kappa B (NF-κB) without affecting the activation of mitogen-activated protein kinase (MAPK) pathways such as JNK, ERK, and p38 MAPK. In addition, we found that peiminine suppressed inflammatory cytokine expression and ameliorated histological symptoms in C. acnes-induced mouse skin. Our study is the first to provide evidence that peiminine has an inhibitory effect on acne, and it points toward the potential of incorporating peiminine into cosmetic and pharmaceutical formulations for acne treatment.

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Section: Discussionmentioning

confidence: 99%

Peiminine Exerts Its Anti-Acne Effects by Regulating the NF-κB Pathway

Cha,

Kim,

Shin

et al. 2024

Antioxidants

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“…Significant phytochemicals identified in these extracts were trigonelline, salsolinol, vanillin, isovanillic acid, ferulic acid and rutin (Figure 18). Molecular docking revealed that the latter (rutin) possess the highest binding affinity towards both TLR2 and NF-κB [52].…”

Section: Musaceaementioning

confidence: 99%

Bioactive Compounds from Natural Sources as Potential Adjuvants in the Treatment of Mild Acne Vulgaris

Cristani,

Micale

2024

Preprint

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In recent years, there has been a growing interest in the use of medicinal plants and phytochemicals as potential treatments for acne vulgaris. This condition, characterized by chronic inflammation, predominantly affects adolescents and young adults. Conventional treatment typically targets the key factors contributing to its development: the proliferation of Cutibacterium acnes and the associated inflammation. However, these treatments often involve the use of potent drugs. As a result, the exploration of herbal medicine as a complementary approach has emerged as a promising strategy. By harnessing the therapeutic properties of medicinal plants and phytochemicals, it may be possible to address acne vulgaris while minimizing the reliance on strong drugs. This approach not only offers potential benefits for individuals seeking alternative treatments but also underscores the importance of natural remedies in dermatological care. The primary aim of this study was to assess the antimicrobial, antioxidant, and anti-inflammatory properties of plants and their phytochemical constituents in the management of mild acne vulgaris. A comprehensive search of scientific databases was conducted from 2018 to September 2023. The findings of this review suggest that medicinal plants and their phytochemical components hold promise as treatments for mild acne vulgaris. However, it is crucial to note that further research employing high-quality evidence and standardized methodologies is essential to substantiate their efficacy and safety profiles.

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“…Significant phytochemicals iden tified in these extracts were trigonelline, salsolinol, vanillin, isovanillic acid, ferulic acid and rutin (Figure 18). Molecular docking revealed that the latter (rutin) possesses the high est binding affinity towards both TLR2 and NF-κB [31].…”

Section: Musaceaementioning

confidence: 99%

“…Figure 18. Some of the main bioactive compounds isolated by Savitri D. et al from M. balbisiana Colla peel extracts[31] …”

mentioning

confidence: 99%

Bioactive Compounds from Medicinal Plants as Potential Adjuvants in the Treatment of Mild Acne Vulgaris

Cristani,

Micale

2024

Molecules

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In recent years, there has been a growing interest in the use of medicinal plants and phytochemicals as potential treatments for acne vulgaris. This condition, characterized by chronic inflammation, predominantly affects adolescents and young adults. Conventional treatment typically targets the key factors contributing to its development: the proliferation of Cutibacterium acnes and the associated inflammation. However, these treatments often involve the use of potent drugs. As a result, the exploration of herbal medicine as a complementary approach has emerged as a promising strategy. By harnessing the therapeutic properties of medicinal plants and phytochemicals, it may be possible to address acne vulgaris while minimizing the reliance on strong drugs. This approach not only offers potential benefits for individuals seeking alternative treatments but also underscores the importance of natural remedies of plant origin in dermatological care. The primary aim of this study was to assess the antimicrobial, antioxidant, and anti-inflammatory properties of plants and their phytochemical constituents in the management of mild acne vulgaris. A comprehensive search of scientific databases was conducted from 2018 to September 2023. The findings of this review suggest that medicinal plants and their phytochemical components hold promise as treatments for mild acne vulgaris. However, it is crucial to note that further research employing high-quality evidence and standardized methodologies is essential to substantiate their efficacy and safety profiles.

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Anti-inflammatory effects of banana (Musa balbisiana) peel extract on acne vulgaris: In vivo and in silico study

Cited by 5 publications

References 60 publications

Peiminine Exerts Its Anti-Acne Effects by Regulating the NF-κB Pathway

Peiminine Exerts Its Anti-Acne Effects by Regulating the NF-κB Pathway

Bioactive Compounds from Natural Sources as Potential Adjuvants in the Treatment of Mild Acne Vulgaris

Bioactive Compounds from Medicinal Plants as Potential Adjuvants in the Treatment of Mild Acne Vulgaris

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